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Öğe Effects of Zinc Deficiency and Supplementation on the Glycogen Contents of Liver and Plasma Lactate and Leptin Levels of Rats Performing Acute Exercise(Humana Press Inc, 2003) Baltacı, Abdülkerim Kasım; Özyürek, Kürşat; Moğulkoç, Rasim; Kurtoğlu, Erdal; Özkan, Yasemin; Çelik, İlhamiThe aim of the present study was to investigate how zinc (Zn) deficiency and supplementation affect glycogen content of the liver and plasma lactate and leptin levels of rats performing acute swimming exercise just before the blood samples were obtained. Four sets of 10 rats each served as the (1) Zn-deficient group, (2) Zn-supplemented group, (3) swimming controls, and (4) normal controls. Plasma lactate levels of Zn-deficient animals were significantly higher than those in the other three groups (p < 0.01), and those in the swimming controls (group 3) were significantly higher than in the Zn-supplemented animals, group 2 (p < 0.01). The plasma glucose of the Zn-deficient group was significantly higher than all other groups (p < 0.01) and that of group 2 was significantly lower than group 4 (p < 0.01). Glycogen levels in liver of the Zn-deficient animals was significantly lower than groups 2 and 4 (p < 0.01), and, in turn, were higher than for group 3 (p < 0.01). The plasma leptin and Zn levels of group 1 were significantly lower than in all other groups (p < 0.01). These results suggest that Zn deficiency exerts a negative influence in the above-mentioned parameters and that Zn supplementation has the opposite effect.Öğe Histologic Characteristics and Local Cellular Immunity of the Gland of the Third Eyelid After Topical Ophthalmic Administration of 2% Cyclosporine for Treatment of Dogs With Keratoconjunctivitis Sicca(Amer Veterinary Medical Assoc, 2002) İzci, Celal; Çelik, İlhami; Alkan, Fahrettin; Oğurtan, Zeki; Ceylan, Cengiz; Sur, Emrah; Özkan, YaseminObjective-To evaluate the efficacy of topical administration of a 2% solution of cyclosporine (CsA) for treatment of dogs with keratoconjunctivitis sicca (KCS) and to correlate results with histopathologic characteristics and local cellular immunity of the gland of the third eyelid. Animals-24 dogs with bilateral KCS. Procedure-Lacrimal secretion was measured, using Schirmer tear test (STT) strips. Leukocyte and T-lymphocyte subsets were determined in blood samples. Histopathologic changes as well as CD4+, CD8+, and alpha-naphthyl-acetate esterase-positive (ANAE+) lymphocytes were evaluated. Results-Clinical signs resolved at the end of 1 month in conjunction with significantly increased STT values, compared with baseline values. Fifteen and 30 days after discontinuation of CsA treatment, a decrease was observed in STT values in both eyes; however, only values for the right eye were significantly different. There was a significant decrease in the number of lymphocytes and ANAE+ lymphocytes 15 and 30 days after discontinuation of CsA treatment, compared with baseline values. Differences were not observed in number of CD4+ lymphocytes among treatment groups. However, there was a significant decrease in number of CD8+ lymphocytes with reversal of the CD4+:CD8+ in both eyes after CsA treatment for 30 days, compared with the control group. Increased secretory activity and decreased lymphocyte infiltration were characteristic histopathologic findings. Conclusions and Clinical Relevance-Topical administration of a 2% solution of CsA was effective for the treatment of dogs with KCS. Strict follow-up monitoring is required after the cessation of treatment because of the possibility of recurrence of KCS.Öğe Koyunlarda Deneysel Olarak Oluşturulan Geni?ş Fıtık Deli?kleri?ni?n Deri? Otogrefti ile Onarılmasının Kli?ni?k ve Histoloji?k Olarak Araştırılması(Selçuk Üniversitesi, 1999) Alkan, Fahrettin; Yavru, Nur; Ceylan, Cengiz; Çelik, İlhami; Boydak, Murat; Özkan, YaseminThe aim of this experimental study was to evaluate the aplicability of autogenic skin graft in the treatment of large hernial defects in sheep. Total of 24 sheep used, were divided into 4 groups. Each groups had 6 sheep. Skin flaps, approximately 11 cm in diameter and 15 cm in length were removed over the umbilical area. Consequently, her nial defect corresponding to the removed skin flap size, were created through the removal of abdominal musculuture and periton. Epidermal and dermal layers of skin flaps facing to the abdominal wall were placed in 3 sheep of each groups Sheep were euthanized in 15, 30, 45 and 60 days, in groups 1, 2, 3 and 4, respectively Following this, tissue. samples were collected from different spots of autogen skin flaps and submitted for histologic evaluations. It was concluded that skin autograft was superior to other hernioplasty materials because of the elasticity, easy applicability and inexpensiveness.Öğe Serbest Diş Hekimlerinin İmplant Tedavisine Yaklaşımları: Anket Çalışması(Selçuk Üniversitesi, 2021) Yıldız, Coşkun; Kazan, Zübeyir; Kahramanoğlu, Erkut; Özyer, Elçin Keskin; Özkan, YaseminAmaç: Günümüzde diş eksikliklerinin telafisinde implant uygulamaları yaygın bir şekilde tercih edilmektedir. Bu çalışmanın amacı serbest diş hekimlerinin implant uygulamalarında kullandıkları teknikleri, yaptıkları planlamaları ve komplikasyonlarla karşılaştıklarında buldukları çözüm yollarını değerlendirmektir. Gereç ve Yöntemler: Bu çalışmada 125 uzman olmayan diş hekimine ulaşılmış ve implant uygulaması hakkında 28 sorudan oluşan anket uygulanmıştır. Planlama, diagnoz teknikleri, kullanılan ölçü tekniği ve materyalleri, kullandıkları implant markaları, karşılaştıkları komplikasyonlar, kullandıkları üst yapı malzemeleri sorgulanmıştır. Bulgular: Katılımcıların implant üstü protetik tedaviler için tercih oranları dört implant destekli sabit protezler için %37,6; altı implant destekli sabit protezler için %19,1; 2 implant destekli hareketli protetik tedavilerde ball ataçman tipi için %29,8; locator ataçman için %13 olarak bulunmuştur. İmplant üstü sabit restorasyonlarda simante restorasyonlar vidalı sistemlere göre daha sık tercih edilmektedir. Diş hekimleri implant tedavisinin tanı ve planında en sık (%35) panoramik röntgenlerden destek almaktadır. İmplant üstü protetik restorasyonlar için diş hekimlerinin %71'i metal seramik restorasyonları tercih ederken; %26,7’si zirkonyum destekli restorasyonları tercih etmektedirler. İmmediat yükleme prosedürünü çalışmamıza katılan hekimlerden sadece %14’ü tercih ettiğini bildirmişlerdir. İmplant üstü restorasyonların ölçüsünün alınmasında hem açık hem de kapalı kaşık tekniklerinin kullanıldığı görülmüştür. Hekimlerin %76 oranında 8.5 mm ve daha uzun implantları tercih ettikleri ve %73 oranında çapı 3.7 ve 4.2 mm arasındaki implantları kullandıkları görülmüştür. Bu çalışmada en çok peri-implantitis komplikasyonu ile karşılaşıldığı gözlenmiştir. İmplant tedavisi uygulanan hastaların sıklıkla 6 ay- 1 yılda bir kontrole çağırıldığı görülmüştür. Sonuç: Çalışmamızda hekimlerin vaka sınıflamasına göre farklı tedavi seçenekleri ve materyalleri seçtikleri görülmüştür. Protetik tedavi planlanması sırasında; implant destekli sabit protezler daha çok tercih edilmektedir.Öğe Use of the fertilized hen's egg in the evaluation of embryotoxicity of dental alloys(WILEY-LISS, 2005) Durmuş, Ercan; İnan, Özgür; Çelik, İlhami; Sur, Emrah; Özkan, Yasemin; Acar, Aslı; Aydın, Mehmet FarukIn this study, embryotoxic effects of five commercially available dental alloys were investigated by using fertilized hens' eggs. One sample of each alloy was conditioned in one of the conditioning media, physiological saline (PS), 0.1 M phosphate-buffered saline (PBS, pH 7.4), and 0.1 M protein (3% bovine serum albumin, BSA) containing PBS (pH 6.8), respectively. The test solutions were injected into the fertilized hen's eggs via air sac at the beginning of the incubation. Various concentrations of a highly embryotoxic substance, AFB(1), was also used as positive control test material. Mortality of the AFB(1) treatment groups increased with increasing concentrations of AFB(1), and the mortality values were significantly (p < 0.05) higher than those of the controls and eluent injected groups. The eluents of five commercially available dental alloys tested in the study did not have significant embryotoxic effects. Cu- and Pd-containing alloys displayed relatively high but statistically insignificant embryotoxic effects. Chick embryo might be used in determination of the embryotoxic effects of the dental alloys with its several advantages. Nevertheless, the test should be further standardized and new methods such as micronucleus test showing possible genotoxic effects of the materials should be used. (C) 2004 Wiley Periodicals, Inc.
