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    The Relationship between uric acid/HDL ratio and monocyte/HDL ratio and glycemic control in male type 2 diabetic patients
    (Selçuk Üniversitesi, 2024) Öztürk, Semra Özkan; Ecin, Seval Müzeyyen
    Background: Type 2 diabetes mellitus (T2DM) is a major health problem worldwide. As glycemic control worsens, the risk of both microvascular and macrovascular complications increases. The aim of this study is to investigate the relationship between blood glucose regulation and two different parameters: uric acid/HDL ratio (UHR) and monocyte/HDL ratio (MHR) in male subjects with type 2 diabetes. Methods: In this retrospective study, a total of 166 male patients diagnosed with type 2 diabetes and 83 healthy adult men as a control cohort were included. Diabetic male participants were equally divided into two subgroups: the group with uncontrolled blood glucose (HbA1c levels exceeding 7, n=83) and the group with good glycemic control (HbA1c levels at or below 7, n=83). Our analysis included assessment of several serum markers, including triglyceride, high-density lipoprotein (HDL), uric acid, low-density lipoprotein (LDL), neutrophil, lymphocyte, monocyte, white blood cell, hemoglobin and platelet levels. In addition, uric acid/HDL ratio, body mass index and monocyte/HDL ratio were compared. Results: Creatinine levels were normal in all study participants and ages were similar in the groups. Triglyceride levels were significantly higher in diabetic patients compared to the healthy group (P<0.001). In contrast, diabetic patients had lower HDL levels than healthy subjects (P=0.002). Serum uric acid levels were lower in the blood glucose unregulated group than in the blood glucose well-regulated group and healthy subjects (P<0.001). UHR was lower in the blood glucose unregulated group compared to the blood glucose well-regulated group and healthy subjects (P=0.003). White blood cell, neutrophil and lymphocyte counts were higher in diabetic patients than in the healthy group (P<0.001, P<0.001, P=0.002). Platelet count and MHR values were higher in the blood glucose-unregulated group compared to the blood glucose-regulated group and healthy subjects (P=0.007). Conclusion: Increased MHR and decreased UHR levels are associated with uncontrolled blood glucose regulation in male patients with type 2 diabetes.