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Öğe Adma Levels in Acute and Stable Chronic Obstructive Pulmonary Disease(Blackwell Publishing, 2006) Erdem, S.; Abuşoğlu, Sedat; Ünlü, Ali; Kanat, Fikret[Abstract not Available]Öğe Alterations of Thyroid Hormone Levels in Cadmium Exposure(DERMAN MEDICAL PUBL, 2017) Akgöl, Evren; Tutkun, Engin; Yılmaz, Hinc; Yılmaz, Fatma Meriç; Gündüzöz, Meside; Bal, Ceylan Demir; Ünlü, AliAim: Environmental chemicals and heavy metals may alter thyroid hormone levels via several mechanisms, including disruption of iodine (I) transport, thyroid peroxi-dase, thyroid hormone-binding proteins, hepatic catabolism, deiodinases, and receptor binding. Our aim was to investigate the change in thyroid hormone levels in cadmium exposure. Material and Method: Painters, welders, miners, and smelters with an occupational exposure of more than 10 years, aged between 18-70 years, were divided into six groups according to whole blood cadmium levels (Group 1: 0-0.5 mu g/L; Group 2: 0.5-1 mu g/L; Group 3: 1-1.5 mu g/L; Group 4: 1.5-2 mu g/L; Group 5: 2-2.5 mu g/L; Group 6: > 2.5 mu g/L). Results: There was a positive correlation between cadmium and serum free thyroxine and triiodothyronine levels. There was a negative correlation between cadmium and serum alanine aminotransferase and vitamin B12 levels. Discussion: Cadmium exposure was found to lead to an increase in thyroid hormone levels.Öğe Alterations of thyroid hormone levels in cadmium exposure -- 2(WILEY-BLACKWELL, 2013) Tutkun, E.; Yılmaz, H.; Abuşoğlu, Sedat; Yılmaz, F. M.; Gündüzöz, M.; Bal, Ceylan D.; Ünlü, Ali[Abstract not Available]Öğe Antithrombin-III, MPV and plasma total homocysteine levels in Behcet's disease(WILEY-BLACKWELL, 2016) Akyürek, F.; Akyürek, Fatma Tunçez; Özdemir, M.; Vatansev, H.; Ünlü, Ali[Abstract not Available]Öğe Assessment of serum ischemia-modified albumin, prolidase and thiol-disulphide levels in subjects with breast cancer.(UNIV PRESS, 2019) Abuşoğlu, Sedat; Eryavuz, Duygu; Bal, Ceylan; Nural, Cemil; Özcan, Erel; Yıldırımel, Mehmet; Çelik, Saadet; Ünlü, AliBackground: Oxidative damage is of great importance for patients with breast cancer. Thus, studies were performed to identify the relationship between breast cancer and oxidative stress biomarkers. Objectives: In this study, our aim was to find out the oxidative and antioxidant status, serum thiol-disulphide levels in subjects with breast cancer. Methods: This study was conducted between March and June 2018 with 82 control subjects (aged between 3267 years) and 127 breast cancer patients (aged between 27-66 years) (p= 0.058) in Selcuk University Faculty of Medicine, Konya, Turkey. Serum myeloperoxidase (MPO), catalase, prolidase were analyzed with kinetic spectrophotometric and thiol-disulphide, ischemia-modified albumin (IMA), ceruloplasmin were detected by colorimetric methods. Results: Serum levels of catalase [199.3 (16.4-489.9) vs 81.6 (18.2-322.9) (kU/L)], MPO [124 +/- 28 vs 101 +/- 31 U/L], disulphide [25 (11-61) vs 18 (2-41) mu mol/L], IMA [0.66 (0.31-3.30) vs 0.62 (0.19-1.31) absorbance unit (ABSU)] and prolidase levels [2217 +/- 538 vs 1456 +/- 401 U/L] were higher in patients than control subjects (For all p< 0.001 except for IMA p=0.031). Native thiol [342 +/- 60 vs 391 +/- 52 mu mol/L] and total thiol levels [396 +/- 56 vs 430 +/- 52 mu mol/L] were lower in patients compared with the control group (For all p< 0.001). Conclusions: Levels of serum thiol/disulphide and prolidase might be reliable indicators for determining oxidative status in certain patient populations.Öğe Association between endocrinological, immunological and psychosocial variables in psoriasis patients(EDIZIONI MINERVA MEDICA, 2016) Bilgiç, Özlem; Bilgiç, Ayhan; Sivrikaya, Abdullah; Selvi, Yavuz; Ünlü, Ali; Altınyazar, Hilmi CevdetBACKGROUND: There is limited data concerning the relationship between psychosocial problems of psoriasis patients and the function of their hypothalamic-pituitary-adrenal (IPA) axis and immunologic markers. This study aimed to determine serum levels of basal cortisol and adrenocorticotropic hormone (ACTH) and circulating levels of various cytokines and chemokines and their association with psychological measures in psoriasis patients. METHODS: Serum concentrations of endocrinological and immunological variables were quantified, and psychiatric questionnaires were completed. RESULTS: In psoriasis patients, serum levels of ACTH, TNF-a, IL-6, IL-23, CCL-17, CCL-27, CCL-20 and CXCL-9, current psychiatric symptoms and childhood neglect scores were all higher than in controls. In addition, in psoriasis patients, physical neglect scores were related to lower basal cortisol, whereas recent stressful life events were related to higher IL-6, IL-23 and CCL-20 levels. CONCLUSIONS: The exposure to stressful life events in childhood and just before a flare-up of psoriasis may be related to altered function of the HPA axis and an immune dysregulation in psoriasis.Öğe Association Between Exaggerated Blood Pressure Response to Exercise and Serum Asymmetric Dimethylarginine Levels(Japanese Circulation Soc, 2010) Kayrak, Mehmet; Bacaksız, Ahmet; Vatankulu, Mehmet Akif; Ayhan, Selim S.; Taner, Alparslan; Ünlü, Ali; Yazıcı, Mehmet; Ülgen, Mehmet S.Background: The exaggerated blood pressure response to exercise (EBPR) is an independent predictor of hypertension. Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide inhibitor and higher plasma levels of ADMA are related to increased cardiovascular risk. The aim of this study is to identify the relationship between ADMA and EBPR. Methods and Results: A total of 66 patients (36 with EBPR and 30 as controls) were enrolled in the study. EBPR is defined as blood pressure (BP) measurements >= 200/100 mmHg during the treadmill test. All the subjects underwent 24-h ambulatory BP monitoring. L-arginine and ADMA levels were measured using a high performance lipid chromatography technique. The serum ADMA levels were increased in the EBPR group compared to the healthy controls (4.0 +/- 1.4 vs 2.6 +/- 1.1 mu mol/L respectively, P=0.001), but L-arginine levels were similar in the 2 groups (P=0.19). The serum ADMA levels were detected as an independent predictor of EBPR (odds ratio 2.28; 95% confidence interval 1.22-4.24; P=0.002). Conclusions: Serum ADMA levels might play a role in EBPR to exercise.Öğe Astımlı çocuklarda serum periostin ve soluk havasında nitrik oksit düzeyi(2018) Dikener, Ahmet Hakan; Özdemir, Hülya; Ceylan, Ayça; Ünlü, Ali; Artaç, HasibeAmaç: Periostin, havayolu epitelinden ve akciğer fibroblastlarından, IL-4 ve IL-13 aracılığı ile salgılanan ekstrasellüler matriks proteinidir. Eozinofilik havayolu inflamasyonun göstergesi olduğu kabul edilmektedir. Çalışmada, astımlı çocuk hastalarda serum periostin düzeyinin değerlendirilmesi ve soluk havasında nitrik oksit (FeNO) düzeyleri ile korelasyonunun belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmaya 7-17 yaş arası, 60 intermittan ve hafif persistan astımlı (29 allerjik, 31 allerjik olmayan) ve 30 sağlıklı kontrol, toplam 90 çocuk (45 kız, 45 erkek) dahil edildi. Hastaların demografik verileri, eozinofil yüzdesi, solunum fonksiyon testi, deri prik testi ve spesifik IgE düzeyleri kaydedildi. FeNO ve serum periostin düzeyi ölçüldü. Bulgular: Çalışmaya alınan tüm bireylerde serum periostin değerlerinin yaşla anlamlı korelasyonu olduğu ve yaşla birlikte azaldığı görüldü (6-12 yaş grubunda 59.0812.79 ng/dl, 13-18 yaş grubunda 46.1811.64 ng/dl, p0.001). Serum periostin düzeyi allerjik astımlı hastalarda 52.1013.93 ng/dl, allerjik olmayanlar da 54.6113.05 ng/dl olup anlamlı fark saptanmadı. FeNO değerleri hasta ve sağlıklı kontrol grubu ile karşılaştırıldığında farklı değildi (15.5 ppb ve 14.0 ppb, p0.486). Hasta grubunda sadece allerjik hastaların FeNO ve periostin değerleri arasındaki korelasyon değerlendirildiğinde istatistiksel olarak anlamlılık saptanmadı (r0.327, p0.077). Ayrıca, serum periostin düzeyi sadece polen duyarlılığı olan grupla karşılaştırıldığında polisensitize olan astımlı çocuklarda daha yüksekti ancak fark istatistiksel olarak anlamlı değildi (58.215.1 ve 44.658.3, p0.065). Sonuç: Bu çalışma ile yeni biyobelirteç olan serum periostin düzeyi çocukluk çağındaki astımlı hastalarda değerlendirildi ve yaşla anlamlı korelasyonunun olduğu gösterildi. İntermittan ve hafif persistan astımlı hastalarda serum periostin düzeyinde anlamlı değişiklik saptanmadı. Çocukluk çağında orta ve ağır persistan astımda, serum periostin düzeyinin değerlendirilmesi için ayrıca çalışmalara ihtiyaç vardır.Öğe Behçet hastalarında asimetrik dimetilarginin düzeyleri(2014) Öztürk, Bahadır; Vatansev, Hüsamettin; Taner, Alpaslan; Yılmaz, Sema; Dağlı, Mehmet; Ünlü, AliAmaç: Behçet Hastalığı (BH), etiyolojisi tam olarak anlaşılmamış, kronik, inflamatuvar multisistemik bir vaskülittir. Nitrik Oksit (NO), endotel hücrelerinde Nitrik Oksit Sentaz (NOS) enzimi tarafından sentezlenen, vasküler sistem için önemi olan bir moleküldür. Asimetrik dimetilarjinin (ADMA) NOS'ın endojen inhibitörüdür. Bu çalışmada BH'larında ADMA düzeyleri ve ataklarla ilgisinin araştırılması amaçlandı.Metod: 34 Behçet hastası ve 34 sağlıklı kontrol çalışmaya dâhil edildi. Serum ADMA, arjinin ve sitrülin düzeyleri HPLC yöntemi ile saptandı. ESR ve CRP düzeyleri rutin yöntemlerle analiz edildi.Bulgular: Literatür bilgilerine ters olarak Behçet hastalarında ADMA düzeyleri kontrol grubuna göre düşük bulundu. Bunun aksine Arjinin ve Sitrülin düzeyleri Behçet hastalarında anlamlı derecede yüksek bulundu. Hasta grubunda Arjinin/ADMA oranları yüksek bulundu. ADMA ve CRP düzeyleri arasında ters bir korelasyon vardı. Arjinin değerleri de sitrülin ve CRP düzeyleri ile koreleydi. Sonuç: BH da genç yaşta atakların sayısının fazla olmasının sebeblerinden birisi düşük ADMA düzeyleri olabilir. Bizim çalışmamız hasta grubundaki düşük ADMA düzeylerine, yaşlanma ile BH alevlenmelerini ve NO aracılıklı inflamasyonu azaltması nedeniyle muhtemel önleyici bir rol yüklemektedirÖğe Changes in Serum Levels of ADMA, SDMA and L-NMMA with Helicobacter Pylori Eradication(AVES, 2017) Baldane, Süleyman; Korkmaz, Hüseyin; İpekci, Süleyman Hilmi; Sözen, Mehmet; Abuşoğlu, Sedat; Akar, Tarık; Ünlü, AliObjective: Increased asymmetric dimethylarginine (ADMA) levels are associated with reduced nitric oxide (NO) levels in many systems, particularly the cardiovascular system, and cause adverse effects. The objective of this study is to evaluate the effect of eradication therapy in patients infected with Helicobacter pylori (H. pylori) on the serum level of ADMA and other metabolic products of methylarginine. Methods: Patients who were found positive both in urea breath tests and stool antigen tests were considered to have H. pylori infection. These patients received eradication therapy for 14 days (twice daily pantoprazole 40 mg, twice daily amoxicillin 1000 mg, and twice daily clarithromycin 500 mg). Blood samples were taken to measure serum ADMA, symmetric dimethylarginine (SDMA), and N-monomethyl-Larginine (L-NMMA) levels before eradication therapy and 3 months after the therapy for patients for whom eradication was achieved. Results: A total of 23 of the 45 patients included in the study were female, whereas 22 were male. The mean age of the patients was 32.4 +/- 8 years. Significant reductions in the serum ADMA, SDMA, and L-NMMA levels of the patients were observed post-eradication therapy versus pre-eradication therapy. Conclusion: This study demonstrated significant reductions in serum ADMA, SDMA, and L-NMMA levels with H. pylori eradication. Further extensive long-term studies are needed to evaluate the positive effects that reduced serum ADMA, SDMA, and L-NMMA levels after H. pylori eradication can have on all systems, particularly the cardiovascular system.Öğe Comparative effects of high-dose atorvastatin versus moderate-dose rosuvastatin on lipid parameters, oxidized-LDL and inflammatory markers in ST elevation myocardial infarction(ELSEVIER IRELAND LTD, 2015) Aydın, Meryem Ülkü; Aygül, Nazif; Altunkeser, Bülent Behlül; Ünlü, Ali; Taner, AlpaslanBackground: The important role of oxidized low density lipoprotein (oxidized-LDL) in preclinic atherosclerosis and pathophysiology of acute coronary syndromes studies have reported. Oxidation of LDL activates many inflammatory and atherogenic pathways and plays a pivotal role in atherosclerosis. Our aim in this study is to compare the effects of 80 mg daily dose of atorvastatin and 20 mg daily dose of rosuvastatin on lipid profiles and the levels of oxidized-LDL and inflammatory markers in ST elevation myocardial infarction (STEMI). Methods: One hundred and twenty patients with STEMI were enrolled in this study. The patients were randomly assigned to receive atorvastatin (80 mg/day) or rosuvastatin (20 mg/day) by using a ratio of 1: 1 after revascularization. The levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), LDL-C, apolipoprotein B and apolipoprotein A were compared between groups after 4-week therapy. The values of oxidized-LDL, tumor necrosis factor receptor 1 and 2, Interleukin-6 and hs-CRP were also compared between groups. The Student's t test was used to detect absolute and percent changes between groups, and p < 0.05 was considered as statistically significant for all tests. Results: After treatment in both treatment groups LDL-C, oxidized-LDL, hs-CRP, tumor necrosis factor receptor 1 and 2, Interleukin-6 values significantly decreased according to baseline. The only difference was in HDL-C levels. HDL-C slightly decreased in atorvastatin group while it increased in the rosuvastatin group compared baseline ( 1.4 +/- 8.9 mg/dl vs 2.0 +/- 9.4 mg/dl, p = 0.04). Conclusion: We reported that both statin treatment regiments have comparable effects on LDL-C, oxidized-LDL and inflammatory markers. Moreover, it was observed that rosuvastatin was more effective in terms of ability to increase HDL-C level. Based on these findings, 20 mg daily dose of rosuvastatin may be an alternative to 80 mg daily dose of atorvastatin in patients with acute coronary syndrome. (C) 2015 Elsevier Ireland Ltd. All rights reserved.Öğe A comparison between two different automated total 25-hydroxyvitamin D immunoassay methods using liquid chromatography-tandem mass spectrometry(CROATIAN SOC MEDICAL BIOCHEMISTS, 2015) Koçak, Fatma Emel; Öztürk, Bahadır; Işıklar, Özben Özden; Genç, Özlem; Ünlü, Ali; Altuntaş, İrfanIntroduction: Total 25-hydroxyvitamin D [25(OH)D] is the most reliable indicator of vitamin D status. In this study, we compared two automated immunoassay methods, the Abbott Architect 25-OH Vitamin D assay and the Roche Cobas Vitamin D total assay, with the liquid chromatography-tandem mass spectrometry (LC-MS/MS). Materials and methods: One hundred venous blood samples were randomly selected from routine vitamin D tests. Two of the serum aliquots were analyzed at the Abbott Architect i2000 and the Roche Cobas 6000's module e601 in our laboratory within the same day. The other serum aliquots were analyzed at the LC-MS/MS in different laboratory. Passing-Bablok regression analysis and Bland-Altman plot were used to compare methods. Inter-rater agreement was analyzed using kappa (kappa) analysis. Results: The Roche assay showed acceptable agreement with the LC-MS/ MS based on Passing-Bablok analysis (intercept: -5.23 nmol/L, 95% CI: -8.73 to 0.19; slope: 0.97, 95% CI: 0.77 to 1.15). The Abbott assay showed proportional (slope: 0.77, 95% CI: 0.67 to 0.85) and constant differences (intercept: 17.08 nmol/L; 95% CI: 12.98 to 21.39). A mean bias of 15.1% was observed for the Abbott and a mean bias of -14.1% was observed for the Roche based on the Bland-Altman plots. We found strong to nearly perfect agreement in vitamin D status between the immunoassays and LC-MS/MS. (kappa: 0.83 for Abbott, kappa: 0.93 for Roche) using kappa analysis. Conclusion: Both immunoassays demonstrated acceptable performance, but the Roche Cobas assay demonstrated better performance than the Abbott Architect in the studied samples.Öğe Comparison of immunoassay and liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods in the measurement of serum androstenedione levels(WILEY-BLACKWELL, 2016) Yücel, Kamile; Abuşoğlu, Sedat; Ünlü, Ali[Abstract not Available]Öğe Comparison of Immunoassay and Liquid Chromatography-Tandem Mass Spectrometry Methods in the Measurement of Serum Androstenedione Levels(CLIN LAB PUBL, 2018) Yücel, Kamile; Abuşoğlu, Sedat; Ünlü, AliBackground: Recent reports have described inherent problems with androgen immunoassays compared with mass spectrometry analyses. In this study, a new liquid chromatography- tandem mass spectrometry (LC-MS/MS) method was developed according to CLSI rules. The developed method was compared with two immunoassay methods, the enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay (RIA). Methods: After liquid-liquid extraction, a Shimadzu Prominence LC unit coupled to an ABSCIEX API 3200 mass spectrometer with atmospheric pressure chemical ionization was used to quantify serum androstenedione levels. Serum androstenedione results taken from tandem mass spectrometry were compared with the immunoassays. Results: The androstenedione assay was linear up to 50 ng/mL. Lower limit of quantitation and lower limit of detection were 0.195 ng/mL and 0.097 ng/mL, respectively. This method was not affected by matrix effect and other steroid hormone interferences. In this study, the obtained recovery was 69 - 99%, carryover value was determined as 0.026 ng/mL. According to the results of an interference study, androstenedione bias % did not exceed the limit of allowable bias % and 88.7% recovery was acquired for androstenedione. In the LC-MS/MS and ELISA comparison study, the slope value was found as 18.412, intercept -22.87, and r(2) value as 0.1033. In the LC-MS/MS and RIA comparison study, slope value was found as 1.085, intercept 0.4541, and r(2) value as 0.3712. In the RIA and ELISA comparison study, slope value was found as 9.57, intercept -15.5, and r(2) value as 0.19. Conclusions: The LC-MS/MS provides agreement with the results of radioimmunoassay but not with ELISA. This method offers better selectivity compared to immunoassay systems.Öğe Comparison of the Results of Sodium, Potassium, and Chlorine Measured Through Ion Selective Electrode (ISE) Method in Different Devices(Selçuk Üniversitesi, 2022) Akdağ, Turan; Kader, Saadet; Dost, Hüseyin; Ünlü, AliObjective: The measurements of electrolytes are an indispensable part of the routine tests performed in clinical biochemistry laboratories. In the present study, we aimed to evaluate Na, K, and Cl electrolytes with the ISE method in the Mindray BS-800M and Beckman Coulter AU5800 devices. Material and methods: The serum samples were obtained from the healthy volunteers admitted to the Karapınar State Hospital for control purposes between January and April 2021. The sample probe was conducted using the same indirect method in the Mindray BS-800M and Beckman Coulter AU5800 devices, which is an individual sample probe for the ISE method. Results: While the comparative measurements were performed on different devices, the correlations between the electrolytes were found as follows: Na [r=0.964, 95% CI (0.52-0.90)], K [r=0.995, 95% CI (0.09-0.12)], and Cl [r=0.972, 95% CI (0.69-1.12)]. Moreover, a correlation was also found between these results. Conclusion: A consistency between the measured Na, K, and Cl electrolytes was determined on the different analyzers. Also, a positive correlation was determined between those electrolytes. We consider that further and comprehensive studies are needed to elucidate these results.Öğe Determinaton of asymmetric dimethylarginine in body fluids by ABSCIEX API 3200 liquid-chromatography mass spectrometry(WILEY-BLACKWELL, 2013) Ünlü, Ali; Abuşoğlu, Sedat; Akyürek, F.[Abstract not Available]Öğe The early effect of coronary surgery on serum Nt-Pro Bnp levels(WILEY-BLACKWELL, 2015) Akyürek, F.; Ünlü, Ali; Abuşoğlu, Sedat; Oc, M. A. H.[Abstract not Available]Öğe Effect of analysis delay on vitamin D measurement by liquid-chromatography mass spectrometry(WILEY-BLACKWELL, 2015) Ünlü, Ali; Abuşoğlu, Sedat; Akyürek, F.[Abstract not Available]Öğe The effect of vitamin D on MCF-7 breast cancer cell metabolism(COMENIUS UNIV, 2017) Saraçlıgil, B.; Öztürk, B.; Ünlü, Ali; Abuşoğlu, Sedat; Tekin, G.The role of vitamin D in calcium absorption and bone health is known. The studies revealed that vitamin D modulates breast cancer cell growth and it is also associated with a reduced breast cancer risk. The primary objective of this study was to highlight the metabolic effect of Vitamin D on MCF-7 breast cancer cell line. For that purpose, we checked the apoptosis, energy, amino-acid and acylcarnitine levels in cancer cells, that the study propose, that la, 25(OH)(2)D-3 could inhibit cell growth in a dose and time dependent manner. IC50 dose was calculated as 145 nM for vitamin D. We observed the apoptosis level in vitamin D groups, which were 18, 28 and 38.5 % at 24, 48 and 72 hours, respectively. During metabolic screening analysis, it was observed that glutamine, methionine and glutamic acid levels were treated more by Vitamin D groups in cell line and also, that acylcarnitine level was increased in 24 and 48 hour groups when compared to the control, but decreased in 72 hours. Further studies are needed to analyze the role of amino acids and acylcarnitines for early apoptosis and cancer metabolism (Tab. 2, Fig. 4, Ref. 24). Text in PDF www.elis.sk.Öğe The effects of prophylactic zinc and melatonin application on experimental spinal cord ischemia-reperfusion injury in rabbits: experimental study(NATURE PUBLISHING GROUP, 2007) Kalkan, E.; Çiçek, O.; Ünlü, Ali; Abuşoğlu, Sedat; Kalkan, S. S.; Avunduk, M. C.; Baysefer, A.Study design: Experimental study. Objectives: To determine the neuroprotective effects of zinc and melatonin on spinal cord ischemia-reperfusion (I/R) injuries of rabbits. Setting: The Experimental Research Centre of Selcuk University, Konya, Turkey. Methods: Twenty-four male rabbits underwent spinal cord ischemia by clamping the thoraco-abdominal aorta for 20 min. Twenty-minutes before the aortic clamping, animals received zinc, melatonin or a combination of both. Neurological examination of the animals was performed three times during reperfusion period. The animals were killed 24 h after reperfusion. Spinal cord samples were taken for biochemical and histopathological evaluation. Results: Pre-treated animals with zinc, melatonin or combination displayed better neurological outcomes than the I/R group (P < 0.05). Zinc, melatonin and combined treatment prevented spinal cord injury by reducing apoptosis rate (P < 0.05) and preserving intact ganglion cell numbers (P < 0.05). Zinc pre-treatment protected spinal cord by preventing malondialdehyde (MDA) formation (P = 0.002), increasing glutathione peroxidase (GPx) activity(P = 0.002) and decreasing xanthine oxidase enzyme activity (P = 0.026) at molecular level. Melatonin treatment also resulted with MDA formation (P = 0.002), increased GPx activity (P = 0.002) and decreased xanthine oxidase activity(P = 0.026). Conclusion: The results of the study showed that prophylactic zinc and melatonin use in spinal cord I/R not only suppressed lipid peroxidation by activating antioxidant systems but also had significant neuroprotective effects by specifically improving the neurological and histopathological situation.
