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    Effect of Deferoxamine on Na(+)K(+)ATPase Activity After Cerebral Ischemia in Rabbits
    (Riyadh Armed Forces Hospital, 2006) Gürbilek, Mehmet; Topçu, Cemile; Aköz, Mehmet; Barışkaner, Hülagü; Üstün, Mehmet E.; Köylü, Öznur
    Objective: To study the effects of deferoxamine on tissue sodium-potassium adenosine triphosphatase (Na+-K+ ATPase) activity on cerebral ischemia in rabbits. Methods: We cared for the animals in the Pharmacology Department of the Medical School of Selcuk University in 2004. We used 30, New Zealand, 7-day-old male rabbits in the experiment. We anesthetized all the animals with xylazine hydrochloric acid and ketamine. We divided the rabbits equally into 3 groups. In group 1 (n=10) (sham group), we observed baseline levels, and did not apply ischemia. In group 2 (n=10) (untreated group) we produced cerebral ischemia by clamping the bilateral common carotid arteries for 60 minutes, and in group 3 (n=10), we administered deferoxamine (DFO) 50 mg/kg intravenously immediately after opening the clamps. Results: The Na+-K(+)ATPase activity increased after DFO treatment (p=0.045). Conclusion: We conclude that Na+-K(+)ATPase activity in cortical brain tissue was higher in DFO-treated rabbits compared with untreated animals after ischemia.
  • Küçük Resim Yok
    Öğe
    Effect of deferoxamine on Na+K+ATPase activity after cerebral ischemia in rabbits
    (2006) Gürbilek, Mehmet; Topcu, Cemile; Aköz, Mehmet; Barışkaner, Hülagü; Üstün, Mehmet E.; Köylü, Öznur
    Objective: To study the effects of deferoxamine on tissue sodium-potassium adenosine triphosphatase (Na+-K+ ATPase) activity on cerebral ischemia in rabbits. Methods: We cared for the animals in the Pharmacology Department of the Medical School of Selcuk University in 2004. We used 30, New Zealand, 7-day-old male rabbits in the experiment. We anesthetized all the animals with xylazine hydrochloric acid and ketamine. We divided the rabbits equally into 3 groups. In group 1 (n=10) (sham group), we observed baseline levels, and did not apply ischemia. In group 2 (n=10) (untreated group) we produced cerebral ischemia by clamping the bilateral common carotid arteries for 60 minutes, and in group 3 (n=10), we administered deferoxamine (DFO) 50 mg/kg intravenously immediately after opening the clamps. Results: The Na +-K+ATPase activity increased after DFO treatment (p=0.045). Conclusion: We conclude that Na+-K+ATPase activity in cortical brain tissue was higher in DFO-treated rabbits compared with untreated animals after ischemia.