Yazar "Avci, Ebru" seçeneğine göre listele
Listeleniyor 1 - 4 / 4
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Association of Polymorphisms in TCF7L2 Gene with Gastric Cancer Risk: A Preliminary Study in Turkish(DERMAN MEDICAL PUBL, 2015) Kaya, Dudu Erkoc; Arikoglu, Hilal; Sumen, Incilay Celik; Avci, Ebru; Ata, Ozlen; Arslan, EmineAim: The Transcription factor 7-like 2 (TCF7L2) gene, located on chromosome 10q25.3, encodes a transcription factor, which contains a high mobility group box, demonstrated in association with many cancer types. This factor is a critical part of Wnt/beta-catenin signaling pathway that plays key roles in regulation of embryonic development and homeostasis in mature tissues. It is known that the constant activation of Wnt/beta-catenin signaling pathway can cause cancer development. In this study, it is aimed to reveal the association between rs7903146C>T and rs12255372G/T single nucleotide polymorphisms in TCF7L2 gene, the key effector of Wnt/beta-catenin signaling pathway, and gastric cancer and to determine associated risk alleles. Material and Method: In our study, polymorphisms in TCF7L2 gene were genotyped using PCR-PFLP technique in 38 patients with gastric cancer and 48 healthy individuals. The obtained data were statistically analyzed and p<0.06 was accepted significant in all assessments. Results: No significant association was determined between rs7903146C>T and disease (p> 0.05) while 122553720>T polymorphism was associated with the disease under additive model (OR: 0.366 195% Cl: 0.135-0.989] p=0.047). Discussion: This is the first study to examine the association between TCF7L2 gene and gastric cancer risk in Turkish population and suggests that rs12255372C>T could be a potential indicator for gastric cancer. On the other hand, further studies are required which will be carry out in more increased number of samples in a wider population.Öğe The cytotoxic effects of Juglone on pancreatic cancer cells in presence of sodium selenite and sodium ascorbate(LIPPINCOTT WILLIAMS & WILKINS, 2015) Erkoc-Kaya, Dudu; Avci, Ebru; Asik, Aycan; Arikoglu, Hilal[Abstract not Available]Öğe Investigation of juglone effects on metastasis and angiogenesis in pancreatic cancer cells(ELSEVIER SCIENCE BV, 2016) Avci, Ebru; Arikoglu, Hilal; Kaya, Dudu ErkocJuglone, a natural component, is shown to have cytotoxic and apoptotic effects in several cancer cell lines. However, little is known about its effects on invasion and metastasis. In this study, we aimed to determine the antimetastatic effect of juglone in the BxPC-3 and PANC-1 pancreatic cancer cell lines. Cytotoxic effect of juglone was evaluated by using MTT (3-(4,5-Dimethylthiazo1-2-yl)-2,5-Diphenyltetrazolium Bromide) test. The cells were treated with juglone atÖğe Investigation of Juglone's effects on invasion and metastasis in BxPC-3 pancreatic cancer cells(LIPPINCOTT WILLIAMS & WILKINS, 2015) Avci, Ebru; Arikoglu, Hilal; Kaya, Dudu Erkoc[Abstract not Available]
