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    Effects of cafeic acid phenethyl ester, ellagic acid, sulforaphane and curcumin on diazinon induced damage to the lungs, liver and kidneys in an acute toxicity rat model
    (Veteriner Fakultesi Dergisi, 2011) Alp, Hayrullah; Aytekin, İsmail; Esen, Hasan; Başaralı, Kemal; Kul, Seval
    The aim of this study was to investigate the possible protective efects of cafeic acid phenethyl ester (CAPE), ellagic acid (EA), sulforaphane (SFN) and curcumin (CUR) against the toxic efects of diazinon (DI). Sixty Sprague Dawley rats were randomly divided into 10 groups. Five groups were allocated as control groups comprising unmedicated control, CAPE, EA, SFN and CUR control groups. The remaining five groups were the study groups comprising DI, DI + CAPE, DI + EA, DI + SFN, and DI + CUR groups. The animals were sacrified 24 h after drug administrations. DI caused a decrease in acetyl cholinesterase (AChE) activity (P<0.05) and increases in ?-glutamyltransferase (GGT) and amylase activities. It also damaged the kidney, liver, and lung tissues. The negative efects of DI on these enzymes were confirmed histopathologically. Also, CAPE, EA, SFN and CUR reduced amylase and GGT activities and caused an increase in the AChE activities that were increased due to the toxic efects of DI. Thus, it was determined biochemically and histopathologically that these medication reduced the degenerative toxic efects created by DI in the lung, liver and kidney tissues. These findings led us to believe that CAPE, EA, SFN and CUR may be used as protective medicines in acute DI intoxication.
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    Protective effects of caffeic acid phenethyl ester, ellagic acid, sulforaphan and curcuma on malathion induced damage in lungs, liver and kidneys in an acute toxicity rat model
    (ECOLE NATIONALE VETERINAIRE TOULOUSE, 2011) Alp, Harun; Aytekin, İsmail; Esen, Hasan; Alp, Ayşe; Büyükbaş, Sadık; Başaralı, Kemal; Hatipoğlu, Namık Kemal
    The aim of this study was to investigate the possible protective effects of caffeic acid phenethyl ester (CAPE), ellagic acid (EA), sulforaphan (SFN) and curcuma (CUR) against acute malathion (MAL) poisoning in rats. For that, 60 female adult Sprague-Dawley rats were randomly divided into 10 equal groups according to the treatment: whereas one group served as unmedicated control and another was intoxicated with malathion (200 mg/kg, per ox) and served as positive control, rats from the other groups were treated with each of the four antioxidants (CAPE: 10 mu mol/kg, intraperitoneally, EA: 85 mg/kg, per ox, SFN: 0.5 mg/kg, per os and CUR: 1 g/kg, per os) alone or in combination with malathion. One day later, serum AChE (acetylcholinesterase), amylase and GGT (gamma-glutamyltransferase) activities were determined and a histopathological evaluation was performed on lungs, kidneys and liver. In MAL-intoxicated rats, the AChE activity was markedly depleted whereas the GOT and amylase activities were significantly increased compared to the unmedicated controls. In parallel, severe and extended inflammatory and degenerative cell lesions were evidenced in liver, kidneys and lungs. By contrast, changes in the serum enzyme activities were greatly attenuated and the organ damage was also markedly reduced but not completely abrogated when an antioxidant cotreatment has been instituted. In addition, CUR appeared as the more efficient for hindering biochemical and histopathological alterations induced by malathion. These results show the protective effects of CAPE, EA, SFN and CUR on acute malathion poisoning in rats.