Yazar "Battino, Maurizio" seçeneğine göre listele

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    Dietary natural products and their potential to influence health and disease including animal model studies
    (POLSKA AKAD NAUK, INST GENETYKI I HODOWLI ZWIERZAT, 2018) Yeung, Andy Wai Kan; Aggarwal, Bharat Bhushan; Barreca, Davide; Battino, Maurizio; Belwal, Tarun; Horbanczuk, Olaf K.; Berindan-Neagoe, Ioana
    Although biological and pharmacological effects of dietary natural products have been intensively studied, there has been no bibliometric analysis performed on this research field up to now. The current study has aimed to identify and analyze the manuscripts on dietary natural products and their potential to influence health and disease including studies using animal models. Data, including words from titles and abstracts, publication and citation data, have been extracted from Web of Science database and analyzed by the VOSviewer software. Our search has yielded 1,014 manuscripts. The ratio of original articles to reviews was identified to be 1.5:1. Over half of the manuscripts have been published since 2010. The manuscripts have been contributed by 4,301 authors from 1,445 organizations in 76 countries/territories and published in 499 journals. The results from the current study point out that scientific research focusing on the potential of dietary natural products to affect health and disease status (including animal model studies) is expanding, and suggests an increasing significance of this scientific area. With the progressive development and improvement of animal studies, it should be expected that animal models of different human diseases (especially civilization ones) would be an integral part of the research for the evaluation of pharmaceuticals originated from dietary natural products like plants or plant materials. Moreover, natural products can also be fed to animals to improve the quality of animal products, with numerous resulting functional effects.
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    Flaxseed extract induces apoptosis in human breast cancer MCF-7 cells
    (PERGAMON-ELSEVIER SCIENCE LTD, 2019) Hu, Tingyan; Linghu, Kegang; Huang, Siqi; Battino, Maurizio; Georgiev, Milen I.; Zengin, Gökhan; Li, Defang; Deng, Yun; Wang, Y. T.; Cao, Hui
    Significant evidence indicated that flaxseed (Linum usitatissimum) possesses various positive health aspects such as reducing the risk of cancer and cardiovascular diseases. The fatty acids are considered to be responsible for these benefits of flaxseed. Herein, the in vitro effects of flaxseed extract on the growth and apoptosis of human breast cancer MCF-7 cells were investigated. The MCF-7 cells treated with flaxseed extract showed a dose-dependent decrease in cell viability. The flaxseed extract induced reactive oxygen species and the flow cytometric analysis demonstrated that flaxseed fatty acids triggered apoptosis of MCF-7 cells, which was also shown by the loss of mitochondrial membrane potential and caspase cascade reaction. Thus, the flaxseed extract regulated the growth of MCF-7 cells and induced apoptosis. Eventually, the flaxseed could be used as a dietary supplement to prevent breast cancer.
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    Resveratrol, a popular dietary supplement for human and animal health: Quantitative research literature analysis - a review
    (POLSKA AKAD NAUK, INST GENETYKI I HODOWLI ZWIERZAT, 2019) Yeung, Andy Wai Kan; Aggarwal, Bharat Bhushan; Orhan, Ilkay Erdogan; Barreca, Davide; Battino, Maurizio; Belwal, Tarun; Bishayee, Anupam
    Resveratrol is a stilbene-type bioactive molecule with a broad spectrum of reported biological effects. In this sense, the current work provides a comprehensive literature analysis on resveratrol, representing a highly-researched commercially available dietary ingredient. Bibliometric data were identified by means of the search string TOPIC=("resveratrol*") and analyzed with the VOSviewer software, which yielded 17,561 publications extracted from the Web of Science Core Collection electronic database. 'I'he ratio of original articles to reviews was 9.5:1. More than half of the overall manuscripts have been published since 2013. Major contributing countries were USA, China, Italy, South Korea, and Spain. Most of the publications appeared in journals specialized in biochemistry and molecular biology, pharmacology and pharmacy, food science technology, cell biology, or oncology. The phytochemicals or phytochemical classes that were frequently mentioned in the keywords of analyzed publications included, in descending order: resveratrol, trans-resveratrol, polyphenols, flavonoids, quercetin, stilbenes, curcumin, piceatannol, cis-resveratrol, and anthocyanins.