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    Siyanür ve Tiyosiyanatın Toksikokinetiği Üzerine Sodyum Nitritin Etkilerinin Araştırılması
    (Selçuk Üniversitesi, 1998) Tanyıldızı, Sadettin; Pirinçci, İbrahim; Kaya, Sezai; Baydan, Emine
    This study was carried out to determine the effects of sodium nitrites on some toxicoklnetic parameters ol eyanide and thiocyanate in sheep experimentally poisoned with amygdalin In this study, 18 sheep 50 -60 kg weights were used. Amygdalin and sodium nitrite were given and the cyanide and thiocyanate levels in samples were delermined Then some toxicokinetic parameters ol the eyanide and thiocyanate in the blood samples taken at 0.5, 1,2, 4, 8, 24, 48 and 72 th hours were established. The sodium nitrite was given intravenously in doses 5 and 25 mglkg and then the distribution hall-lives of blood eyanide levels according to doses were respectively, 0.23±O.01 and 3.14±1.65 hours; the elimination hall-lives were respectively, 60.80±13.41 and 126±24.33 hours; mean residence times were respectively, 88±10.04 and 18S±2S.21 hours; the duration ol maximal concentration were respectively, 48th hour; the maximal blood levels were respectively, 0.151 and 0148 ?g1ml were determined. Besides, area under the curve values were according to doses were respectively, 11.28±1.24 and 9±S.62 ?g.hour'ml; volume of distribution at steady slate were respectively, 0.03±O.OOI and 0.2±0.03 Ukg; clearance values were respectively, 0.44±O.12 and 0.16±O.09 ml/hour.kg were calculated. The distribution half-lives of blood thiocyanaıe levels according lo doses were respectively, 18.30±2.21 and 29.44±3.41 hours; the elimination half-lives were respectively, 224.43±11.40 and 42.89±8.85 hours; mean residence times were respectively, 137.36±24.2 and 64.38±6.6S hours; the duration of maximal concentration were respectively, 24 and 48th hours; the maximal blood levels were respectively, 0.026 and 0.028 ?g1ml were detennined. Besides, area under the curve values according lo doses were respectively, 4.66±O.21 and 9.82±O.8 ?g.hour/ml; volume ol distribution at steady state were respectively, 0.147±O.03 and 0.162±O.03 Ukg; clearance values were respectively, 1.07±O.31 and 7.72±2.84 mVhour.kg were established .