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    Leptin, insulin and body composition changes during adjuvant taxane based chemotherapy in patients with breast cancer, preliminary study
    (MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2016) Alacacıoğlu, Ahmet; Kebapçılar, Levent; Gökgöz, Z.; Öztekin, O.; Bozkaya, Giray; Tarhan, Oktay; Somalı, Işıl
    BACKGROUND: The objectives of the present study were to compare the effect of adjuvant chemotherapy for breast cancer on serum insulin levels, serum leptin levels, and body composition in early stage breast cancer patients. MATERIALS AND METHODS: 17 breast cancer patients underwent 6 cycles of docetaxel (75 mg), epirubicine (100 mg) and cyclophosphamide (500 mg) (TEC). Anthropometrical and foot-to-foot body fat analyzer BIA, serum glucose, insulin, lipids, HOMA-IR and leptin were compared pre- and post-treatment. RESULTS: There was no statistically significant weight gain after treatment; however, there was an overall trend toward weight gain (69.7 +/- 9.8 kg vs 71.03 +/- 9.8; P = 0.05). From baseline to the end of the study, percentage of body fat and body fat mass showed an upward trend at the end of chemotherapy (1%; 2 kg P > 0.05). Pre and post-treatment period, leptin was strongly correlated with insulin and HOMA-IR (Spearman's pre-T; r = 0.74; P < 0.001, r = 0.66; P = 0.004 post-T; r = 0.549; P = 0.022, r = 0.51; P = 0.036, respectively). Insulin levels were significantly increased in the post-treatment period (P < 0.05). On correlation analysis, post-T insulin levels were correlated with leptin, weight, fat-mass and fat percentage (Spearman's r = 0.549; P =. 022, r = 0.567; P = 0.018, r = 0.498, P = 0.042, r = 0.502; P = 0.040, respectively). DISCUSSION: High insulin and leptin levels, important factors that were previously shown to be related to breast cancer outcome, and insulin resistance may be increased in taxane based chemotherapy regimen. These data may have broad implications for diet and lifestyle strategies for the prevention and treatment of cancers.
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    Soluble CD40 Ligand, High Sensitive C-Reactive Protein and Fetuin-A Levels in Patients with Essential Thrombocythemia
    (PERGAMON-ELSEVIER SCIENCE LTD, 2012) Bilgir, Ferda; Bilgir, Oktay; Kebapçılar, Levent; Çalan, Mehmet; Özdemirkıran, Füsun; Cinali, Türker; Bozkaya, Giray
    Background: CD40 ligand (CD40L) is expressed on the surface of activated platelets and activated T lymphocytes. Circulating soluble CD40 ligand (sCD40L) is formed from these molecules proteolytically. Fetuin-A is a potent antiinflammatory cytokine. Aim of the study: In this study, we aim to investigate sCD40L levels to determine whether there is platelet activation and to measure high sensitive C-reactive protein (hs-CRP) levels to demonstrate if this leads to an inflammatory process and also to study fetuin-A levels to see if there is any concomitant antiinflammatory event in patients with essential thrombocythemia (ET). Methods: We compared 30 patients with essential thrombocythemia with 30 control subjects and in these patients we measured levels of sCD40L, hs-CRP and fetuin-A. Results: sCD40L levels were significantly higher in the Er group compared to the control group (30.6 +/- 14.4 vs. 18.5 +/- 8.9, p = 0.001). Although fetuin-A levels showed a slight trend to be increased in ET patients, the difference did not reach significance (4.5 +/- 4.2 vs. 3.2 +/- 2.1, p = 0.158). There were no statistically significant differences in hs-CRP levels (24.6 +/- 4.9 vs. 25.0 +/- 5.2, p = 0.750). Conclusion: sCD40L was significantly higher in patients with an ET without any association with an inflammatory process and we believe this may be a marker of platelet regeneration.