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The effects of osteoformin on mineralisation and quality of newly formed bone during mandibular distraction osteogenesis in rabbits
(MOSBY-ELSEVIER, 2009) Pampu, A. Alper; Ozkaynak, Ozkan; Senel, Figen Cizmeci; Cankaya, Mustafa; Dolanmaz, Dogan; Ersoz, Safak; Avunduk, Mustafa Cihat
Objective. The aim of this experimental study was to evaluate the effects of osteoformin on mineralization and quality of newly formed bone during distraction osteogenesis in rabbits. Study design. Distraction rate was as 1 mm/day for 5 days. In the experimental group, 100 mu g/kg osteoformin in 100 mu L/kg phosphate-buffered saline (PBS) was injected into the distraction area at day 1 and day 7 after surgery. In the control group, only 100 mu L/kg PBS was injected on the same days. On day 42, the animals were killed. Results. Bone mineral density and bone mineral content values increased significantly in the experimental group (P < .05). Newly formed bone areas, number of vessels and osteoblasts were significantly greater in experimental group (P < .05). The number of fibroblasts were also greater, but it was not significant statistically (P < .05). The number of osteoclasts was significantly lower in experimental group (P < .05). Conclusion. The results of this study show that osteoformin improves healing of regenerate in distraction osteogenesis in rabbits. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 108: 833-837)