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N-Hexane-Toluene Neuropathy in Shoe-makers
(2001) Demir, O.; Akpınar, Z.; Demireli, O.
n-Hexane and toluene are solvents commonly used as glue in the shoe industry and the two substances are synergistic. The development of neuropathy in people subjected to inhalation of these substances were reported by some investigators. In the present study we investigated evidence of clinical and subclinical polyneuropathy in 56 shoe industry workers who have been working in bad ventilated workshops for 3-30 years. None of them had clinical evidence of neuropathy, but they had decreased sensory conduction velocities and amplitudes. Distal motor latencies were prolonged when compared to the control group (p<0.001). Motor conductions were not found to be affected (p>0.05). Development of neuropathy was not directly correlated to duration of exposure of the solvents (p>0.05). We concluded that subclinical peripheral neuropathy developed in subjects who were exposed to inhalation of n-hexane and toluene. Preventing them from working in insufficiently ventilated workshops is of importance from aspects of preventive medicine.