Yazar "Duran, Cevdet" seçeneğine göre listele
Listeleniyor 1 - 5 / 5
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Comparison of Salivary Cortisol, Serum Cortisol, Plasma ACTH and Urinary Free Cortisol Levels in Thyrotoxic and Hypothyroid Patients(Turkiye Klinikleri, 2012) Gönen, Mustafa Sait; Özkaya, Emin; Kurban, Sevil; İpekçi, Süleyman Hilmi; Duran, Cevdet; Kulaksızoğlu, SevsenHypothalamo-pituitary-adrenal (HPA) axis is affected by thyroid hormones. The present study was designed to compare the level of salivary cortisol, serum cortisol, plasma ad-renocorticotropic hormone (ACTH) and urinary free cortisol (UFC) levels in patients with subcli- nical and overt thyrotoxicosis and hypothyroidism. Material and Methods: W e analyzed the salivary cortisol, serum cortisol, plasma ACTH and UFC levels in 123 patients with thyroid dysfunction. The patients were classified into four groups; overt thyrotoxicosis (n= 32), subclinical thyrotoxico-sis (n= 29), overt hypothyroidism (n= 28) and subclinical hypothyroidism (n= 34). Results: There we-re no significant differences in terms of salivary cortisol, serum cortisol, plasma ACTH and UFC levels in patients with subclinical and overt thyrotoxicosis (p> 0.05). Similarly, no significant dif-ferences could be detected in terms of salivary cortisol, serum cortisol, plasma ACTH and UFC le-vels in patients with subclinical and overt hypothyroidism (p> 0.05). The comparison of patients with hypothyroidism and thyrotoxicosis also did not yield any significant difference in terms of sa-livary cortisol, serum cortisol, plasma ACTH and UFC levels (p> 0.05). Conclusion: Similar salivary cortisol, serum cortisol, plasma ACTH and UFC levels were detected in patients with hypothyroi-dism and thyrotoxicosis. Thus, we may suggest that thyroid hormone status does not play a role in the HPA axis. The major limitation of this study was the absence of a healthy control group. Furt-her studies with large numbers of patients are required to clarify the association between thyroid hormone dysfunction and glucocorticoid levels.Öğe The frequency of metabolic syndrome in patients with acrochordons(IBN SINA TRUST, 2017) Kurtipek, G. Saylam; Duran, Cevdet; Kutlu, Orkide; Ataseven, Arzu; Akyürek, Fatma Tunçez; Kurku, Hüseyin; Elmas, HalisObjective: To investigate the frequency of metabolic syndrome (MetS) in patients with acrochordons. Materials and Methods: 102 patients with acrochordons and 76 controls were enrolled into the study. The presence of MetS was evaluated under the criteria NCEP-ATP III. Results and Discussion: Waist circumference (p<0.001), body mass index (p<0.001), systolic (p=0.014) and diastolic blood pressure (p<0.001), insulin (p<0.001) and triglyceride (TG) levels (p<0.001) were higher in the group with acrochordons. The presence of MetS was found as 71.6% in patients with acrochordon and 40.8% in controls (p<0.001). Conclusions: Patients with acrochordons should be evaluated in terms of the presence of MetS and its components.Öğe Frequency of metabolic syndrome in patients with knuckle pads(WILEY-BLACKWELL, 2015) Kurtipek, Gülcan Saylam; Kutlu, Orkide; Duran, Cevdet; Kurku, Hüseyin; Ataseven, Arzu; Akyürek, Fatma TunçezKnuckle pads are hyperkeratotic, benign skin lesions that we commonly observe in obese patients. There is no study that investigates the association between metabolic syndrome (MetS) and knuckle pads. We aimed to investigate the frequency of MetS in patients with knuckle pads. Forty-seven patients with knuckle pads and 46 age-and sex-matched controls were enrolled. The presence of MetS was evaluated according to National Cholesterol Education Program-Adult Treatment Panel III criteria. In the patient group, waist circumference (P < 0.01), body mass index (BMI; P < 0.01), and systolic (P < 0.01) and diastolic blood pressure (P < 0.01) were higher than controls, and most of the patients had a history of hypertension (P < 0.01). The presence of MetS was found in 66% of the patients with knuckle pads and in 52.2% of the controls (P = 0.25). In the patient group, compared with controls, more patients had blood pressure above reference values or were on antihypertensive therapy (70.2% and 43.5%, P = 0.017, respectively), and had greater waist circumference value (93.6% and 76.1%, P = 0.038, respectively). The presence of the other three criteria were similar in both groups. Although we found similar MetS frequency in both groups, patients with knuckle pads should be examined for the presence of MetS components, especially abdominal obesity and hypertension.Öğe Frequency of Thyroid Nodules Among Patients with Colonic Polyps(Hindawi Publishing Corporation, 2012) Duran, Cevdet; Göktürk, Hüseyin Savaş; Kulaksızoğlu, Mustafa; Bakdık, Süleyman; Ünler, Gülhan Kanat; Erbayrak, Mustafa; Özkaya, Güven; Pamuk, Barış Önder; Gönen, Mustafa SaitAim. Colonic polyps and thyroid nodules are common diseases and their frequency increases with age. In the literature, there is no study investigating the coexistence of colonic polyps and thyroid nodules. Therefore, this study was designed to investigate thyroid nodule prevalence in patients with colonic polyps. Material and Methods. Sixty-six patients with colonic polyps and 146 patients without colonic polyps enrolled into the study. Age and sex matched control group was composed from patients without colonic polyps. Colonoscopic examinations, thyroid ultrasonographies were performed in all patients, and TSH were measured. Results. Male/female ratio in polyp and control groups were 40/26 versus 68/78, respectively (P = 0.058). Mean ages were similar in both groups (53.3 +/- 11.4 versus, 51.8 +/- 11.4, P = 0.373). Thyroid nodule was detected in 44 (66.7%) patients with polyps and in 61 (41.8%) controls (P = 0.001). Patients with adenomatous polyps had 5 or more thyroid nodules compared to patients with hyperplastic polyps (P = 0.03). Thyroid nodules were more prevalent among patients aged 50 or older compared to 50 years or less (P = 0.023). Conclusion. Thyroid nodules were detected more common in patients with colonic polyps. Further studies are needed to clarify this coexistence.Öğe Previous gestational diabetes history is associated with impaired coronary flow reserve(TAYLOR & FRANCIS LTD, 2015) Caliskan, Mustafa; Turan, Yasar; Caliskan, Zuhal; Gullu, Hakan; Ciftci, Faika Ceylan; Avci, Enver; Duran, CevdetBackground Gestational diabetes mellitus (GDM) is a prediabetic state that is known to increase the risk of cardiovascular diseases. We have investigated coronary flow velocity reserve (CFVR) and epicardial fat thickness (EFT), and left ventricular diastolic function in patients with a history of previous GDM (p-GDM). Methods Ninety-three women with GDM history and 95 healthy women without GDM history were recruited. We used transthoracic Doppler echocardiography to assess CFVR, EFT, and left ventricular diastolic function. Insulin resistance of each subject was assessed with homeostasis model assessment insulin resistance (HOMA-IR). Hemoglobin A1c and high-sensitivity C-reactive protein (hsCRP) were also measured in all patients. Results CFVR values were significantly lower (2.34 +/- 0.39 versus 2.80 +/- 0.24, p<0.001) and EFT values were significantly higher in patients with p-GDM than the control group (5.5 +/- 1.3 versus 4.3 +/- 1.1, p<0.001). E/E' ratio (7.21 +/- 1.77 versus 6.53 +/- 1.38, p = 0.003), hemoglobin A1c (5.2 +/- 0.4 and 5.0 +/- 0.3, p = 0.001), HOMA-IR (2.8 +/- 1.4 versus 1.7 +/- 0.9, p = 0.04), and hsCRP levels were significantly higher in the p-GDM group than the control group. Multivariate analysis revealed that gestational diabetes history is independently associated with CFVR. Conclusion Women with a GDM history may be at more risk regarding coronary microvascular dysfunction compared to the healthy ones.
