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    Currarino syndrome: report of five consecutive patients
    (SPRINGER, 2014) Duru, Soner; Karabagli, Hakan; Turkoglu, Erhan; Ersahin, Yusuf
    The Currarino syndrome is regarded as a developmental disorder based on its recognized etiological heterogeneity. This syndrome is thought to result from abnormal separation of the neuroectoderm from the endoderm. Our aim was to report the neurosurgical management of Currarino syndrome in children and adults and to describe what clinician could do if the Currarino triad was suspected. We present five cases of Currarino triad who underwent surgical intervention. All patients had sacral bony deformity, anorectal malformations, and anterior sacral meningocele. A 40-year-old-male had chronic constipation. He was incidentally diagnosed with Currarino syndrome. A 19-year-old-female suffered from a slight weakness in lower extremities and urinary incontinence. Her past medical history was remarkable for anal atresia. The other three cases were children. When an anterior sacral meningocele is encountered, Currarino syndrome should be taken into consideration. Although it is rarity, the Currarino syndrome might be one of the causes of chronic constipation. Endoscopic or endoscope-assisted surgery via a posterior sacral route can be feasible for treatment of some of the patients with anterior sacral meningocele. Anterior meningocele pouch associated with Currarino syndrome will regresses over time following transdural ligation of its neck.
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    Improvement of non-syndromic Hearing Loss After Treatment of High Cerebrospinal Fluid Pressure. A Case Report
    (JOURNAL NEUROLOGICAL SCIENCES, 2011) Karabagli, Hakan; Duru, Soner; Imer, Murat; Apuhan, Tayfun
    We report a newborn male with hydrocephalus that clinically improved hearing loss after the shunt and also endoscopic procedures. These changes were also documented with audiograms. A newborn 4-month-old male presented with non-syndromic bilateral hearing loss with hydrocephalus. In an attempt to improve his hydrocephalus he underwent two operations; first endoscopic third ventriculostomy, and then ventriculo-peritoneal shunt. After 10 months, his magnetic resonance images displayed double compartment hydrocephalus and shunt malfunction. The otologic work-up revealed sensorineural hearing loss. Therefore, endoscopic the compartments fenestration and catheter placement into the compartments and connection with ventriculo-peritoneal shunt was performed. After the third procedure, he had a significant improvement in intracranial pressure findings and hearing clinically. These changes were documented with audiograms. Non-syndromic hearing loss with hydrocephalus may be treatable by improvement of high cerebrospinal fluid pressure level, if the hearing loss is reversible period. The effect of cerebrospinal pressure levels on intra-cochlear fluid pressure and hearing is briefly discussed.