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    Correlation of Serum Leptin Level and Waist-to-hip Ratio (WHR) With Overall Survival of Patients With Metastatic Breast Cancer (MBC) Treated With Aromatase Inhibitors (AIs).
    (Amer Soc Clinical Oncology, 2013) Artac, Mehmet; Bozcuk, Hakan; Kıyıcı, Aysel; Eren, Orhan Önder; Boruban, Melih Cem; Özdoğan, Mustafa
    Introduction Our objective was to determine whether serum leptin levels and obesity-related factors could affect outcome for metastatic breast cancer (MBC) patients treated with aromatase inhibitors (AIs). Methods Sixty MBC patients treated with first line hormonal therapy were enrolled in this study. Results Median age was 51 years (range 28–75). Median leptin level was 19400 pg/ml (1970–91900) and estradiol level 29.6 pg/ml (4.0–181.9). Factors associated with overall survival in univariate analysis were age and waist-to-hip ratio (WHR), whereas only WHR retained significance in the multivariate analysis. However, no factor was associated with progression-free survival. However, WHR was found to be a significant prognostic marker only if the leptin level was C19400 pg/ml (HR = 0.38; 95% CI: 0.16–0.91). Conclusions This study suggests that serum leptin levels and WHR together may serve as potential prognostic markers in MBC patients treated with AIs.
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    Opinions of Turkish Physicians About the Participation of Patients and/ or Patient Caregivers in Multidisciplinary Tumor Boards; A Survey Study From Tertiary Center in Konya
    (Selçuk Üniversitesi, 2023 Ağustos) Eren, Orhan Önder; Çağlayan, Melek; Körez, Muslu Kazım
    Objective: Multidisciplinary management is very important component of treatment of cancer. Multidisciplinary tumor boards (MTBs) provide the chance for shared-decision making in this complex type of disease. The participation of patients or caregivers in MTBs is a contentious issue and is not common in Turkiye. In this study we aimed to determine what Turkish physicians participating MTBs in Selcuk University Faculty of Medicine think about the participation of patients and caregivers in MTBs. Method: The study was conducted in Selcuk University Faculty of Medicine in August 2022. The physicians that accepted to participate completed a 9-item questionnaire. The relationships between the participants’ sociodemographic characteristics and their questionnaire responses concerning MTBs were analyzed using Pearson’s chi-square test or the Fisher-Freeman-Halton test. Results: No statistically significant correlation was found between the socio-demographic characteristics of the participants and the opinions of cancer patients or their relatives about their participation in multidisciplinary tumor boards. 50 % of the participants do not approve participation of patient or caregivers in MTBs. 35 % of participants approved the participation of both in the MTBs. 4.4 % of participants approved only the participation of caregivers whereas only the 8.9 % of medical oncologist approved only the participation of patients in tumor board. Conclusion: Among 45 Turkish physicians in a tertiary care center, half of the participants did not approve of the participation of patients or caregivers in MTBs. The major reason for this lack of approval was the fear that patients and caregivers would not understand medical terminology which might lead to misunderstanding by patients or caregivers.