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    Assessment of ten-year-long results of kidney biopsies performed on children in the thrace region of Turkey
    (GALENOS YAYINCILIK, 2016) Özkayın, Neşe; Çıplak, Gökçe; Usta, Ufuk; Gençhellaç, Hakan; Temizöz, Osman
    Background: Many children with kidney diseases can be diagnosed and treated without a biopsy. However, biopsy is a valuable method for the diagnostic and prognostic evaluation of children with kidney diseases. Aims: To evaluate the clinical and pathological profiles of the kidney biopsies in our department to provide epidemiological data for clinical practice. Study Design: Retrospective cross-sectional study. Methods: Kidney biopsies and patient's charts in pediatric patients performed between May 2005 and February 2015 at the Pediatric Nephrology Department, Trakya University School of Medicine were assessed retrospectively. Results: A total of 100 patients were examined. Their mean age was 9.62 +/- 4.26 years (range: 1-17 years); 54% of the patients were girls and 46% were boys. The most frequent indication for kidney biopsy was nephrotic syndrome (33%). The most common kidney disease was primary glomerulonephritis, which was observed in 65% of cases. IgA nephropathy (24%) was the most frequently observed subtype in primary glomerulonephritis groups. Secondary glomerulonephritis was diagnosed in 35% of cases. Systemic lupus erythematosus (51%) was the most frequently observed subtype in the secondary glomerulonephritis groups. Conclusion: IgA nephropathy and systemic lupus erythematosus were the most frequent primary and secondary glomerulonephritis in our region among children, respectively.
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    Diffusion weighted magnetic resonance imaging for the characterization of solitary pulmonary lesions
    (AVES, 2015) Çakır, Cağlayan; Gençhellaç, Hakan; Temizöz, Osman; Polat, Ahmet; Şengül, Ersin; Duygulu, Gökhan
    Background: We evaluated the differential diagnosis of solitary pulmonary lesions on magnetic resonance imaging. Aims: To investigate the value of diffusion weighted imaging on the differential diagnosis of solitary pulmonary lesions. Study Design: Randomized prospective study. Methods: This prospective study included 48 solitary pulmonary nodules and masses (18 benign, 30 malignant). Single shot echo planar spin echo diffusion weighted imaging (DWI) was performed with two b factors (0 and 1000 s/mm(2)). Apparent diffusion coefficients (ADCs) were calculated. On diffusion weighted (DW) trace images, the signal intensities (SI) of the lesions were visually compared to the SI of the thoracic spinal cord using a 5-point scale: 1: hypointense, 2: moderately hypointense, 3: isointense, 4: moderately hyperintense, 5: significantly hyperintense. For the quantitative evaluation, the lesion to thoracic spinal signal intensity ratios and the ADCs of the lesions were compared between groups. Results: On visual evaluation, taking the density of the spinal cord as a reference, most benign lesions were found to be hypointense, while most of the malignant lesions were evaluated as hyperintense on DWI with a b factor of 1000 s/mm(2). In contrast, on T2 weighted images, it was seen that the distinction of malignant lesions from benign lesions was not statistically significant. The ADCs of the malignant lesions were significantly lower than those of benign lesions (mean ADC was 2.02x10(-3) mm(2)/s for malignant lesions, and 1.195x10(-3)+/- 0.3 mm(2)/s for benign lesions). Setting the cut-off value at 1.5x10(-3), ADC had a sensitivity of 86.7% and a specificity of 88.9% for the differentiation of benign lesions from malignant lesions. Conclusion: DWI may aid in the differential diagnosis of solitary pulmonary lesions. (ClinicalTrials. gov Identifier: NCT02482181)