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    Does the Presence of Endometrial Polyp Predict Colorectal Polyp?
    (ELSEVIER SCIENCE INC, 2016) Unler, Gulhan Kanat; Gokturk, Huseyin Savas; Toprak, Erzat; Erinanc, Ozgur Hilal; Korkmaz, Huseyin
    Introduction: Endometrial polyps (EPs) and colorectal polyps (CPs) are common disorders and the incidence of both increase rapidly with aging. CPs are focal lesions and incidence increases with age. Aim: In this study, we aimed to analyze retrospectively the relationship between the EPs and CPs sharing similar clinical and genetic factors in their etiopathogenesis. Materials and Methods: This study was retrospectively performed between 2010 and 2013 and it included patients diagnosed to have eEPs. The study group and the control group consisted of patients who were diagnosed with or without EPs and who underwent colonoscopy at the same period. Results: The study group was formed by 57 patients with diagnosis of EP who underwent colonoscopy during the same period. The control group consisted of 71 patients without EP examined with colonoscopy. Among 128 patients assessed in this study, 24 were diagnosed with CPs, all of which were adenomatous polyps smaller than 1 cm. No hyperplastic or inflammatory polyps were diagnosed. While 18 of 57 patients with EPs had CPs, 6 of 71 control subjects had CPs. Hence, the risk of having CP was 5 times greater in patients with EP compared to those without (P < 0.05). Conclusion: The present study demonstrated that the prevalence of CPs increased significantly in postmenopausal patients with EPs. Recommending colonoscopy to these patients irrespective of age may be beneficial for detecting more CPs and preventing colorectal cancer.
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    Non-Invasive Estimation of Disease Activity and Liver Fibrosis in Non-Alcoholic Fatty Liver Disease Using Anthropometric Biochemical Characteristics, and C-13-Methionine Breath Test
    (WILEY-BLACKWELL, 2015) Korkmaz, Huseyin; Unler, Gulhan K.; Gokturk, Huseyin Savas; Schmidt, Wolfgang E.; Kebapcilar, Levent
    [Abstract not Available]
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    Routinely evaluated clinical assays and laboratory tests [real test] and fibrosis stages of chronic hepatitis B and C
    (AVES, 2014) Bugdaci, Mehmet Sait; Korkmaz, Huseyin; Demir, Ali; Biyik, Murat; Temel, Tuncer; Gokturk, Huseyin Savas; Ozakyol, Aysegul
    Background/Aims: To provide a new mathematical formula to predict liver fibrosis in patients with chronic viral hepatitis. Materials and Methods: Patients with chronic hepatitis B and C who underwent liver biopsy at different centers were included in this study. Chronic hepatitis B was defined as immunopositivity for the hepatitis B surface antigen for at least 6 months, and chronic hepatitis C was defined as positivity for HCV RNA for at least 3 months. The histological features were evaluated by the histological activity index and fibrosis. Results: In total, 1299 patients were included in the study. The distribution and the mean of the parameters of the patients were as follows: 1009 patients with chronic hepatitis B with a mean age of 45 +/- 13/years [emale/male (F/M)=47.5/52.5%] and 290 patients with hepatitis C with a mean age of 52 +/- 10.3/years [F/M=61/39%]. When the cut-off value of the REAL TEST formula"[(age x pT x AST)/(PLT/1000)]/100" in patients with hepatitis B was determined to be >= 1.37, it was found that it could predict fibrosis with 79% specificity, 78% sensitivity, 85% negative predictive value (NPV), and 70% positive predictive value (PPV) (area under the curve (AUC)=0.852, 95% CI: 0.82-0.87). When the cut-off value of the REAL TEST formula in patients with hepatitis C was determined to be >= 1.99, it was found that it could predict significant fibrosis with 87% specificity, 90% sensitivity, 94.4% NPV, and 79.4% PPV (AUC: 0.95, 95% CI: 0.93-0.98) Conclusion: The REAL TEST formula results correlated with the pathological findings and may be a useful method for the evaluation of patients with chronic hepatitis B and C.
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    Russell Body Gastritis: Case Report and Review of the Literature
    (MEDICAL UNIV PRESS, 2012) Karabagli, Pinar; Gokturk, Huseyin Savas
    An unusual and rare gastric mucosal lesion histologically consisting of Russell bodies and plasma cell infiltration and termed as Russell body gastritis is presented. In the literature there are only ten such case reports and of these, seven including this present case were associated with Helicobacter pylori infection. The high rate of Helicobacter pylori infections in cases of Russell body gastritis suggests that the correlation is not merely coincidental. All data in the literature related to Russell body gastritis were scanned, and histopathologic findings and the clinical characteristics associated with such lesions were discussed.