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    Pharmacokinetics of flunixin after intravenous administration in healthy and endotoxaemic rabbits
    (SPRINGER, 2006) Elmas, M; Yazar, E; Uney, K; Karabacak, A
    The pharmacokinetics of flunixin were determined after intravenous bolus injection at a single dose (2.2 mg/kg) in healthy rabbits and diseased rabbits with Escherichia coli lipopolysaccharide-induced septic shock. Six adult New Zealand White rabbits were used. Concentrations of drug in plasma were determined by HPLC. Pharmacokinetics were best described by a two-compartment open model. In healthy rabbits, there was a high plasma clearance (0.62 L/(h kg)), and a relatively short elimination half-life (1.19 h). In endotoxaemic rabbits, total plasma clearance (0.43 L/(h kg)) was significantly lower (p < 0.05), and elimination half-life (1.90 h) and AUC(0-infinity) (5.29 (mu g h)/ml) were significantly higher (p < 0.05) than in healthy animals. The changes of pharmacokinetics of flunixin in rabbits with septic shock could be of clinical significance, and may require monitoring of plasma flunixin levels in endotoxaemic status.
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    Pharmacokinetics of flunixin-meglumin following intravenous administration in Angora rabbits
    (NATL VETERINARY RESEARCH INST, 2005) Elmas, M; Uney, K; Karabacak, A; Yazar, E
    The pharmacokinetics of flunixin-meglumin were determined after intravenous bolus injection at two different doses (1.1 and 2.2 mg/kg body weight) in rabbits. Six healthy adult Angora rabbits were used in the experiment. Blood samples were collected at 10, 20, 30, 45 and 60 min, 2, 4, 6, and 8 h after injection. Concentrations of drug in plasma were determined by HPLC. Pharmacokinetics were described by a two-compartment open model. The area under the curve, contrary to other pharmacokinetic parameters, showed statistically significant differences between the two doses used (P < 0.05). The data obtained for the low and high doses were as follows: the elimination half-lives were 1.4 and 1.7 h, the volume of distribution - 0.6 and 0.8 L/kg, and total body clearance - 0.32 and 037 mL/h/kg body weight, respectively. The present study has shown that the pharmacokinetic variables of fluxin-meglumin in Angora rabbits are dose independent in the dose range of 1.1-2.2 mg/kg body weight.