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    Are There Interchromosomal Effects of Chromosomal Rearrangements on Occurrence of Aneuploidy in Sperm Nuclei of Carriers?
    (Nature Publishing Group, 2002) Acar, H.; Yakut, T.; Çora, Tülün; Egeli, Ünal; Kaynak, M.; Yıldırım, S.
    [Abstract not Available]
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    Micronuclei Induction in Rat Embryonic Blood Cells Following Exposure to Different Modes of Electromagnetic Fields
    (NATURE PUBLISHING GROUP, 2002) Aksoy, Melih; Acar, H.; Karabulut, K.; Salbacak, Ahmet; Uysal, I.; Kaynak, M.
    [Abstract not Available]
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    Reliability and Efficiency of Interphase-Fish With ?-Satellite Probe for Detection of Aneuploidy
    (2002) Acar, H.; Yıldırım, Mahmud Selman; Kaynak, M.
    Early diagnosis is very important in pre- and postnatal diagnosis of Down syndrome. This study examines the use of fluorescence in situ hybridization (FISH) to detect trisomy 21 in interphase nuclei and metaphase chromosome obtained from fifty-four Down syndrome patients with a regular type trisomy 21. Three of them showed six hybridization signals on both interphase nuclei and metaphase spreads instead of five signals corresponding to two chromosomes 13 and three chromosomes 21 although they were cytogenetically trisomy 21. Simultaneous application of probe combination revealed that one of the extra signals of chromosomes 13/21 ?-satellite probe was located on chromosome 22 in two cases and one extra signal on chromosomes 15 in one case. In addition, another case showed four hybridization signals on both interphase nuclei and metaphase spreads instead of five signals, indicating deletion of the chromosome specific ?-satellite DNA sequence of chromosome 13/21. These centromeric sequence changes may have pathological significance in the appearance of aneuploidy because they may be involved in the important centromere function.
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    Reliability and Efficiency of Interphase-Fish With Alpha-satellite Probe for Detection of Aneuploidy
    (MEDECINE ET HYGIENE, 2002) Acar, H.; Yıldırım, M. S.; Kaynak, M.
    Reliability and efficiency of interphase-FISH with a-satellite probe for detection of aneuploidy: Early diagnosis is very important in pre- and postnatal diagnosis of Down syndrome. This study examines the use of fluorescence in situ hybridization (FISH) to detect trisomy 21 in interphase nuclei and metaphase chromosome obtained from fifty-four Down syndrome patients with a regular type trisomy 21. Three of them showed six hybridization signals on both interphase nuclei and metaphase spreads instead of five signals corresponding to two chromosomes 13 and three chromosomes 21 although they were cytogenctically trisomy 21. Simultaneous application of probe combination revealed that one of the extra signals of chromosomes 13/21 a-satellite probe was located on chromosome 22 in two cases and one extra signal on chromosomes 15 in one case, In addition, another case showed four hybridization signals on both interphase nuclei and metaphase spreads instead of five signals, indicating deletion of the chromosome specific a-satellite DNA sequence of chromosome 13/21. These centromeric sequence changes may have pathological significance in the appearance of aneuploidy because they may be involved in the important centromere function.