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    Radiotherapy-induced Hypopituitarism in Nasopharyngeal Carcinoma: the Tip of an Iceberg
    (JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH, 2015) Ipekci, S. H.; Cakir, M.; Kiyici, A.; Koc, O.; Artac, M.
    Background: Radiation-induced hypopituitarism is an important late complication of cranial radiotherapy in children and adults. The purpose of this cross-sectional study was to evaluate the effects of radiotherapy on pituitary function in adult nasopharyngeal carcinoma patients. Methods: Pituitary function was evaluated in 30 patients after cranial radiotherapy for nasopharyngeal carcinoma. Somatotroph and corticotroph axes were assessed by insulin tolerance test while gonadotroph and thyroid axes were evaluated by basal pituitary and end organ hormone levels at 10-133 months after radiotherapy. Results: At least one hormonal disorder was observed in 28 (93%) patients after radiotherapy. 26 (87%) patients had one or more anterior pituitary hormone deficiencies. The rates of pituitary hormone deficiencies were 77% for growth hormone, followed by adrenocorticotropic hormone (73%), thyroid-stimulating hormone (27%) and gonadotropins (7%). Hyperprolactinemia was present in 13 (43%) patients. Conclusions: Radiation-induced hypopituitarism is more common than expected in patients with nasopharyngeal carcinoma.
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    Rapid percutaneous nephrostomy catheter placement in neonates with the trocar technique
    (ELSEVIER MASSON, 2017) Ozbek, O.; Kaya, H. E.; Nayman, A.; Saritas, T. B.; Guler, I.; Koc, O.; Karakus, H.
    Purpose: The purpose of this study was to assess the efficacy of a modified percutaneous nephrostomy procedure for grade III-IV hydronephrosis in neonates. Material and methods: Eleven neonates (five girls, six boys) with a mean age of 13.7 days +/- 9.9 (SD) (range, 4-28 days) with pronounced hydronephrosis had percutaneous nephrostomy using a modified procedure. In all patients, percutaneous nephrostomy was performed with a trocar catheter under ultrasound guidance and then the catheter was placed into the collecting system without prior dilatation. Results: Technical success was achieved in all patients. There were no major procedure-related complications. There was no perirenal hematoma on control ultrasound examinations and no hematuria was observed after the procedure. The median drainage time was 75 days (range: 42-120 days). Two children had urinary tract infection, which was controlled by using antibiotics. Conclusion: The trocar nephrostomy is a practical and feasible method, which can be used for neonates with grade III-IV hydronephrosis. (C) 2016 Editions francaises de radiologie. Published by Elsevier Masson SAS. All rights reserved.
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    Subungual glomus tumour: magnetic resonance imaging findings
    (BLACKWELL PUBLISHING, 2007) Koc, O.; Kivrak, A. S.; Paksoy, Y.
    The present study aims to present a case of a subungual glomus tumour with literature to the findings on magnetic resonance (MR) imaging. A 51-year-old man consulted his physician because of a pain in the nail bed of his thumb, which he had had for 2 years. A plain radiography and MR examination was performed. Physical examination showed a blue-brown focus beneath the nail and there was deformation. A plain radiography demonstrated no abnormality. T1-weighted spin-echo images showed a well-marginated, oval, slightly hyperintense lesion (4 mm diameter) located in the subungual region. On turbo spin-echo T2-weighted images the lesion was hyperintense with a hypointense rim. T1-weighted spin-echo images after intravenous administration of contrast medium showed strong enhancement. The lesion was completely excised at surgery and the diagnosis of a glomus tumour was established histologically. In conclusion, MR imaging offers excellent diagnostic information about a clinically suspected glomus tumour.