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Öğe Beneficial Effects of Levosimendan on Cerebral Vasospasm Induced by Subarachnoid Haemorrhage: An Experimental Study(Taylor & Francis Ltd, 2010) Cengiz, Şahika Liva; Erdi, Mehmet Fatih; Tosun, Murat; Atalık, Esra; Avunduk, Mustafa Cihat; Sönmez, Fatma Cavide; Mehmetoğlu, İdris; Baysefer, AlperBackground: The aim of this study was to investigate the ability of levosimendan to prevent cerebral vasospasm in a rabbit model of subarachnoid haemorrhage (SAH). Animals and methods: Eighteen New Zealand white rabbits were allocated into three groups randomly. SAH was induced by injecting autologous blood into the cisterna magna. (Group 1 = control: sham surgery group, Group 2 = SAH alone group, Group 3 = SAH plus levosimendan group). Histopathological examination was performed on day 3 as described. Intravenous levosimendan dose (initially 12 mu g kg(-1) infusion, continuously for at least 10 minutes and then continued with a dose of 0.2 mu g kg(-1) min(-1)) treatment was started after the induction of SAH. Three days later, the animals were sacrificed. Results: In pathological investigation; there was statistically significant difference in luminal area and muscular wall thickness of the basilar artery between all groups (p < 0.005). Malondialdehyde level was also found significantly low in the levosimendan group compared with the SAH group. Conclusion: Intravenous levosimendan treatment was found effective by increasing the pathological luminal area and reducing muscular wall thickness measurements. This is the first study to show that intravenous administration of levosimendan is effective in preventing cerebral vasospasm induced by SAH in rabbits.Öğe Çay, baharat ve bitki kaynaklı bazı gıda maddelerinin flavonoid içerikleri ve antioksidan özellikleri(2005) Mehmetoğlu, İdris; Ünlü, Muhteşem Cemile; Gökçe, Recep; Kurban, SevilSerbest radikaller ve antioksidan (AO) denge insan sağlığı açısından büyük öneme sahiptir. Dışardan besinlerle çeşitli AO’lar alınmakta olup bunların başlıcaları AO vitaminler ve flavonoidler adı verilen bileşiklerdir. Son yıllarda çok sayıda önemli AO flavonoid keşfedilmiş ve kaynakları incelenmiştir. Flavonoidlerin en önemli kaynağı da başta çay olmak üzere baharatlar ve çeşitli sebze ve meyvelerdir. AO içeriği yüksek gıdalarla beslenme (sebze, meyve ve diğerleri) kanser, diabetes mellitus, yaşlanma, kardiyovasküler ve serebrovasküler hastalıkları da kapsayan bir grup hastalığa karşı korunma sağlar. Bu derlemedeki amacımız sıkça tüketilen çay, baharatlar ve bitki kaynaklı diğer bazı gıda maddelerinin flavonoid içeriklerini ve AO özelliklerini irdelemektir.Öğe Effect of Diet Oils on Lipid Levels of the Brain of Rats(Blackwell Publishing, 2006) Kurban, Sevil; Mehmetoğlu, İdris; Yılmaz, GülsümThe effects of sunflower oil, olive oil, margarine, soybean oil and butter on cholesterol and triglyceride levels were investigated in the brain of rats. Rats were fed with a diet containing 15 % of the oils for a period of 8 weeks. The rats were then decapitated, brain samples were removed, homogenized and cholesterol and TG levels were measured. Brain cholesterol and Triglycerides levels of all animals receiving different oils were significantly higher according to the contol except TG level of animals receiving margarine. Brain cholesterol levels of the vegetable oils were statistically higher than those receiving saturated oil. Thus, cholesterol level of the rats fed with olive oil group was significantly higher than that of the other groups but those receiving sunflower oil group and Triglycerides level of the animals receiving olive oil was significantly higher than that of the other groups except animal supplemented with soybean oil. Thus, it is concluded that brain lipid levels of rats are differently effected by various oils and mechanism of which needs to be investigated.Öğe Effects of Acetylsalicylic Acid on Serum Paraoxonase Activity, Ox-LDL, Coenzyme Q10 and Other Oxidative Stress Markers in Healthy Volunteers(PERGAMON-ELSEVIER SCIENCE LTD, 2010) Kurban, Sevil; Mehmetoğlu, İdrisObjectives: The aim of the study was to examine the effects of acetylsalicylic acid (ASA) on oxidative stress in healthy volunteers. Design and Methods: 30 volunteers of which 17 received ASA as 100 mg/day (Group 1) and 13 received ASA as 150 mg/day (Group 11) for 2 months. Serum paraoxonase 1 (PON1), arylesterase, total antioxidant status (TAS), total oxidant status (TOS), oxidized LDL (Ox-LDL) and coenzyme Q(10) (CoQ(10)) levels were measured before and I and 2 months after treatment. Results: There was no significant differences between the measured parameters of the groups. However, TOS and Ox-LDL levels of group 11 were significantly reduced after 2 months of treatment (p<0.05). Conclusions: Significantly inhibition of LDL oxidation and significantly reduction in TOS levels of group II after 2 months of ASA treatment shows that ASA treatment may contribute to the prevention of atherosclerosis, a beneficial effect which is dose and time dependent.Öğe Effects of phototherapy on serum paraoxonase activity and total antioxidant capacity in newborn jaundice(Nobelmedicus, 2014) Kurban, Sevil; Annagür, Ali; Altunhan, Hüseyin; Mehmetoğlu, İdris; Örs, Rahmi; Erdem, Said Sami; Yerlikaya, Fatma HümeyraObjective: Phototherapy is an efficient and commonly used form of therapy for the treatment of neonatal hyperbilirubinemia. Paraoxonase 1 (PON1) is an antioxidative enzyme, which eliminates lipid peroxides. The aim of our study was to investigate the effect of phototherapy on serum PON1 activity and total antioxidant capacity (TAC) in hyperbilirubinemic full-term newborns.Material and Method: The study was performed on 40 full-term newborns between 3 to 15 days of age exposed to phototherapy.Serum PON1 activity and TAC levels of the babies were determinedbefore and after phototherapy by spectrophotometric assays.Results: We have found that PON1 activity was not significantly affected by phototherapy whereas TAC levels were decreased significantly after phototherapy (p<0.001).Conclusion: Our findings demonstrated that phototherapy has no direct effect on PON1 activity. Also, decreased TAC levels might have resulted from increased oxidative stress which may lead to consumption of antioxidant molecules. © 2014, Nobelmedicus. All rights reserved.Öğe EFFECTS OF PHOTOTHERAPY ON SERUM PARAOXONASE ACTIVITY AND TOTAL ANTIOXIDANT CAPACITY IN NEWBORN JAUNDICE(NOBEL ILAC, 2014) Kurban, Sevil; Annagür, Ali; Altunhan, Hüseyin; Mehmetoğlu, İdris; Örs, Rahmi; Erdem, Said Sami; Yerlikaya, Fatma HümeyraObjective: Phototherapy is an efficient and commonly used form of therapy for the treatment of neonatal hyperbilirubinemia. Paraoxonase 1 (PON1) is an anti oxidative enzyme, which eliminates lipid peroxides. The aim of our study was to investigate the effect of phototherapy on serum PON1 activity and total antioxidant capacity (TAC) in hyperbilirubinemic full-term newborns. Material and Method: The study was performed on 40 full-tenn newborns between 3 to 15 days of age exposed to phototherapy. SerumPON1 activity and TAC levels of the babies were determined before and after phototherapy by spectrophotometric assays. Results: We have found that PON1 activity was not significantly affected by phototherapy whereas TAC levels were decreased significantly after phototherapy (p<0.001). Conclusion: Our findings demonstrated that phototherapy has no direct effect on PON1 activity. Also, decreased TAC levels might have resulted from increased oxidative stress which may lead to consumption of antioxidant molecules.Öğe Effects on Wound Healing of Different Incision Instruments: Experimental Study(2012) Şahin, Mustafa; Baysal, B.; Yılmaz, Hüseyin; Alptekin, Hüsnü; Uğraş, Serdar; Mehmetoğlu, İdrisObjective. Wound healing effects of scalpel, electrocautery, peak plasmablade, which are used for skin incisions and intestinal incisions, were searched. Material and method. 36 wistar albino rats 10-week were used as experimental animals. 3 groups were created. There were 12 wistar albino rats in each groups. Laparotomy by scalpel and transection to ascending colon were applied in the group I. The segment, which was transected, was anastomosised at once. The same processes were applied by electrocautery in the group II. The same processes were applied by peak plasmablade in the group III. Experimental animals were sacrified at the 7th post-operative day. 1 ml blood was taken by cardiac puncture for MDA measurement and then relaparotomy was applied. Approximately 4 cm intestinal segment, which included anastomosis line, was resected. Then anastomotic bursting pressures were measured. 4x4 cm2 abdominal wall was removed to measure rupture breaking pressure of incision. Tissue samples were got for incision line's and anastomosis line's histopathological examinations. Results. In the group II, anastomotic bursting pressure and rupture breaking pressure of abdominal wall were found less than the groups I and III. The difference between the groups was statistically reasonable (p<0.05). MDA values of each groups weren't statistically different. At anastomosis and incision line, any reasonable difference was found in terms of 7 criterions, which were evaluated histopathologically. Conclusion. We think that scalpel and peak plasmablade can be used for incisions safely. Peak plasmablade supplies hemostasis. So peak plasmablade shortens operation duration.Öğe Fertil ve infertil şahıslarda seminal sıvı, serum lipid ve testosteron düzeyinin araştırılması(2005) Mehmetoğlu, İdris; Gürbüz, Fatma; Gürbüz, Recai; Gökçe, Recep; Kurban, SevilAmaç: Fertil ve infertil şahıslarda seminal sıvı ile serum lipid ve testosteron seviyeleri arasındaki ilişkinin araştırılması. Çalışmanın yapıldığı yer: Selçuk Üniversitesi, Meram Tıp Fak., Biyokimya ABD, KONYA Materyal ve Metod: Çalışmamızda 21-32yaşları arasında (ortalama 25) 25 fertil şahıs ile 18-42 yaşları arasında (ortalama 29) 30 intertil şahısta serum trigliserid (TG), total kolesterol, yüksek dansiteli lipoprotein (HDL) kolesterol, düşük dansiteli lipoprotein (LDL) kolesterol, total ve serbest testosteron ile seminal sıvı analizi yapıldı. Bütün analizler rutin metodlarla gerçekleştirildi. Bulgular: Fertil şahıslarda total ve serbest testosteron düzeyleri infertil şahıslarınkinden hafif yüksek iken, total kolesterol düzeyleri anlamlı decede düşük, sperm sayısı ise anlamlı derecede yüksekti. İnfertil grupta serum total kolesterol düzeyi ile serum total ve serbest testosteron düzeyleri arasında önemli negatif korelasyon, tüm vakalarda ise serum total kolesterol düzeyi ile sperm sayısı arasında önemli negatif korelasyon bulundu. Sonuç: Bu bulgular, hiperkolesteroleminin koroner kalp hastalığı riski yanında azospermiye ve sonuçta infertiliteye de yol açabileceğini göstermektedir. Bulgularımız, çeşitli araştırmacıların bulguları ile uyum halinde olup literatür bulguları ışığında tartışıldı.Öğe Investigation of eNOS Gene Intron 4 A/B Vntr and Intron 23 Polymorphisms in Patients with Essential Hypertension(Tübitak Scientific & Technical Research Council Turkey, 2010) Mehmetoğlu, İdris; Yılmaz, Gülsüm; Kurban, Sevil; Acar, Hasan; Düzenli, M. AkifAim: Nitric oxide (NO) plays a mayor role in the regulation of vascular tone Production of NO can be influenced by polymorphisms of the endothelial NO synthase (eNOS) gene, which may be associated with the pathogenesis of essential hypertension (EHT) Therefore, eNOS gene intron 4 a/b variable number of tandem repeats (VNTR) and intron 23 polymorphisms were investigated in patients with EHT living in a central area of Turkey. Materials and methods: The study was performed in 91 patients (34 M, 57 F) with EHT, aged 38-76 years, and 75 age- and sex-matched healthy controls (35 M, 40 F). eNOS gene polymorphisms were detected by polymerase chain reaction method. Results: There was no significant difference between the G-allele frequency of the G10-T polymorphism in intron 23 and intron 4 a/b VNTR polymorphism of the eNOS gene in EHT patients and in the controls Conclusion: eNOS gene intron 4 a/b VNTR and intron 23 gene polymorphisms were not associated with EHT patients living in a central area of Turkey Further studies are needed to investigate whether these 2 polymorphisms of the eNOS gene could represent useful genetic markers for indentifying individuals at risk of developing EHT.Öğe Investigation of Plant Sterols, Oxidized Low Density Lipoproteins (LDL) and Homocysteine Levels in Patients with Coronary Arthery Disease and Healthy Controls(Nobel Ilac, 2010) Sivrikaya, Abdullah; Mehmetoğlu, İdris; Kurban, Sevil; Aygül, Nazif; Yerlikaya, F. HümeyraAmaç: Bu çalışma serum bitki sterollerinin (B- sitosterol, stigmasterol) koroner arter hastalığının gelişi- mindeki rolünü ve diğer potansiyel risk faktörleriyle korelasyonunu göstermek için yapıldı. Materyal ve Metod: Anjiografisi yapılan toplam 166 kişi koroner anjiografi sonuçlarına göre kontrol ve hasta olarak gruplandırıldı. Anjiografisi normal olan 60 kışı kontrol grubunu, üç majör koroner arterlerinin en az birinde > %50 stenozu olan 106 kişi hasta grubunu oluşturdu. Vakaların serum ß-sitosterol, stigmasterol, okside LDL ve homosistein düzeyleri analiz edildi Bulgular: Hastalarım serum ß-sitosterol, stigmasterol ve bunların kolesterole oranları, okside LDL ve homosistein düzeyleri kontrollere göre biraz yüksek (istatistiksel açıdan önemsiz) bulundu. Üç hastanın serum bitki sterol seviyelen diğerlerine göre çok yüksekti. Hasta grubunda ẞ-sitosterol ile kolesterol düzeyleri arasında, kontrol grubunda stigmasterol ile kolesterol düzeyleri arasında önemli pozitif korelasyon vardı. Serum bitki sterolleri ile bunların okside LDL, homo- sistein ve koroner oklüzyon seviyeleri arasında ise korelasyon yoktu. • Sonuç: Bulgularımız serum bitki sterollerinin koroner arter hastalarında bağımsız risk faktörü olmadığım göstermektedir. Aynca bu hastalarda diğer risk faktörlerinin yanında serum bitki sterollerinin de rutin olarak ölçülmesmin hastaların daha iyi değerlendirilmesinde çok önemli olacağı kanaatindeyiz.Öğe Investigation of receptor activator of nuclear factor kappaB ligand and osteoprotegerin levels in multiple sclerosis patients(WALTER DE GRUYTER GMBH, 2011) Kurban, Sevil; Akpınar, Zehra; Mehmetoğlu, İdrisAim: The aim of this study was to investigate the osteoprotegerin (OPG) and receptor activator of nuclear factor kappaB ligand (RANKL) levels and their correlation with bone mineral density (BMD) and levels of other bone turnover parameters such as serum osteocalcin, parathyroid hormone (PTH), calcium, bone alkaline phosphatase (bALP) and urinary deoxypyridinoline (DPD) in patients with multiple sclerosis (MS). Methods: Forty six MS patients (30F, 16M, 33.48 +/- 9.57 years old) and 24 healthy controls (14F, 10M, 33.04 +/- 7.97 years old) were included in the study. Serum OPG, RANKL, bALP, osteocalcin, PTH, calcium, urinary DPD levels of all subjects, and BMD of 29 patients and all control subjects were measured. Osteoprotegerin and RANKL levels, bALP, osteocalcin and PTH levels, and urinary DPD levels were measured by ELISA method, chemiluminescent method, and HPLC technique. The BMD was measured by dual-X-ray absorptiometry. Results: Serum OPG (p<0.01), RANKL (p<0.01), bALP (p<0.05), PTH (p<0.01) and calcium (p<0.05) levels were significantly higher in MS patients than in controls. There was no significant difference between serum osteocalcin, urinary DPD levels and BMD measures of the groups. Conclusion: Increased RANKL levels associated with osteoclastogenesis suggests a tendency towards osteoporosis in MS patients. However, no significant change in BMD levels of the subjects shows that the effect of RANKL is compensated by increased OPG levels. OPG and RANKL levels are involved in the pathogenesis and regulation of bone turnover and thus, circulating levels of them may be useful markers to assess bone turnover and to develop new approaches in MS.Öğe Investigation of Serum Crosslinked N-Telopeptides of Type I Collagen (Ntx) Levels and Total Antioxidant Capacity in Patients with Type 2 Diabetes Mellitus(Walter De Gruyter Gmbh, 2010) Kurban, Sevil; Mehmetoğlu, İdris; Gönen, Sait; Akbulut, SevalPurpose: Our aim was to investigate the serum cross-linked N-telopeptides of type I collagen levels and total antioxidant capacity in patients with type 2 diabetes mellitus. Methods: 46 patients with type 2 diabetes mellitus (24M, 22F) aged 41 to 68 years (54.36 +/- 7.92) and 34 healthy controls (17M, 17F) aged 40 to 69 years (52.91 +/- 8.04) were enrolled in the study. Serum cross-linked N-telopeptides of type I collagen levels were measured by enzyme-linked immunosorbent assay method using a commertially available kit, total antioxidant capacity levels were measured by a colorimetric method based on the oxidation of 2,2'-azino-bis (3-ethylbenz-thiazoline-6-sulfonic acid) radical and hemoglobin A(1c) levels were measured by high performance liquid chromatography technique. Results and Conclusion: Serum cross-linked N-telopeptides of type I collagen levels of the patients were significantly higher (p<0.01) whereas total antioxidant capacity levels were significantly lower (p<0.05) than those of the controls. Also, there was a significant positive correlation between serum cross-linked N-telopeptides of type I collagen and hemoglobin A(1c) levels (r=0.301, p<0.05) and a significant negative correlation between total antioxidant capacity and hemoglobin A(1c) levels (r=-0.382, p<0.01) in the patients group. In conclusion, our results show patients with type 2 diabetes mellitus have a significantly reduced total antioxidant capacity levels and there is a risk of bone resorption in these patients which can be estimated by measuring serum cross-linked N-telopeptides of type I collagen levels.Öğe Ischemia-Modified Albumin Levels in Patients with End-Stage Renal Disease Patients on Hemodialysis: Does Albumin Analysis Method Affect Albumin-Adjusted Ischemia-Modified Albumin Levels?(WILEY, 2010) Kıyıcı, Aysel; Mehmetoğlu, İdris; Karaoğlan, Hatice; Atalay, Hüseyin; Solak, Yalçın; Türk, SüleymanIschemia-Modified albumin (IMA) has been used as an early marker in the evaluation of the patients with acute coronary syndrome. We aimed to evaluate IMA in end-stage renal disease (ESRD) patients on hemodialysis and the effect of albumin methods on albumin-adjusted IMA levels. A total of 30 ESRD patients were included in this study. Serum IMA and albumin levels were measured before and after a hemodialysis session. Albumin concentrations were determined with bromocresol green and bromocresol purple methods. Postdialysis IMA and albumin-adjusted IMA levels with two different albumin methods were significantly increased compared with the predialysis levels (P<0.05). However, we did not find any difference in albumin-adjusted IMA levels in either at the beginning or at the end of the dialysis session. IMA levels increase after hemodialysis, whereas albumin method has no effect on albumin-adjusted IMA levels.Öğe Multiple Skleroz Hastalarında Serum Paraoksonaz ve Arilesteraz Aktiviteleri ile Oksidatif Stresin Araştırılması(2010) Kurban, Sevil; Akpınar, Zehra; Mehmetoğlu, İdrisAmaç: Oksidatif stresin multiple skleroz (MS)’un patojenezinin önemli bir komponenti olduğu ile ilgili gittikçe artan sayıda kanıt vardır. Paraoksonaz 1 (PON1) plazma yüksek-dansiteli lipoproteine (HDL) bağlı bir antioksidan enzimdir. Onun düşük-dansiteli lipoprotein (LDL) ve HDL’yi oksidasyona karşı koruduğu ve oksidatif stresi azalttığı gösterilmiştir. Bu çalışmanın amacı oksidatif stres ve MS hastalığı arasındaki ilişkiyi araştırmaktır. Yöntem: Elli MS hastası (17E, 33K) ve 35 sağlıklı kontrolün (15E, 20K) serum PON1 ve arilesteraz aktiviteleri ile total antioksidan durum (TAS) ve total oksidan durum (TOS) seviyeleri karşılaştırıldı. Bulgular: MS hastalarının TAS seviyeleri sağlıklı kontrollerden anlamlı derecede düşüktü (p0,05). MS hastalarının TOS seviyeleri kontrollerden yüksek ve PON1 ve arilesteraz aktiviteleri ise kontrollerden düşük olmasına rağmen bu farklılıklar istatistiksel olarak anlamlı değildi. Sonuç: Çalışmamızda MS hastalarına ait TAS seviyelerinin kontrollere göre anlamlı derecede düşük olmasının sebebi bilinmemekle beraber, endojen antioksidanların MS’de artan oksidatif stres tarafından tüketilmiş olabileceği ve bu hastalara ilave antioksidan verilmesinin faydalı olabileceği kanaatine varıldı.Öğe Obez Çocuklarda Serum Lipidleri ve Lipid Peroksidasyonunun Araştırılması(2001) Aköz, Mehmet; Karaeren, Zihni; Gültekin, Fatih; Gürbilek, Mehmet; Mehmetoğlu, İdris; Vatansev, Hüsamettin; Koç, HasanSerum lipidleri ve lipid peroksidasyonunun araştırılması amacıyla, 7-12 (9.51 \pm 1.12) yaşları arasında 43 sağlıklı normal çocuk ile yaşları 7-12 (9.981.39) arasında 33 obez çocuğun serumlarında trigliserid, total kolesterol, serbest kolesterol, LDL-kolesterol , HDL-kolesterol, HDL2-kolesterol, HDL3-kolesterol, lipoprotein(a) ve lipid peroksidasyonu düzeylerine bakıldı ve sırasıyla obezlerde 120.1953.17 mg/dl, 172.53\pm30.07 mg/dl, 41.30 11.14 mg/dl, 103.51 28.09 mg/dl, 42.487.90 mg/dl, 8.044.75 mg/dl, 34.445.68 mg/ di, 19.4416.91 mg/dl, 3.981.84 nmol/ml; kontrol grubunda 78.3035.11 mg/dl, 151.42 \pm 23.84 mg/dl, 33.659.63 mg/dl, 88.8222.22 mg/dl, 47.036.13 mg/dl, 14.755.62 mg/ml, 32.274.31 mg/ml, 10.458.43 mg/ dl, 3.26\pm1.08 nmol/ml bulundu. Obezlerde trigliserid, total kolesterol, serbest kolesterol, LDL-kolesterol, lipoprotein(a), lipid peroksidasyonu değerlerinin (p0.001, p0.001, p0.005, p0.05, p0.005, p0.05) yüksek, HDL-kolesterol ve HDL2-kolesterol değerlerinin (p0.01, p0.001) düşük, lipid peroksidasyonu değerleri ile vücut kitle indeksi (body mass index) ve ağırlıkları arasında pozitif bir korelasyonun (r0.320, p0.05, r0.368, p0.05) olduğu görüldü. Obez çocukların ateroskleroz riski altında olabilecekleri ve izlemleri sırasında tüm bu parametrelerden yararlanılabileceği düşünüldü.Öğe Okside düşük dansiteli lipoprotein otoantikorları ve klinik önemi(2005) Kurban, Sevil; Mehmetoğlu, İdrisAteroskleroz multifaktöryel bir hastalıktır. Düşük dansiteli lipoprotein (LDL)’nin serbest radikal etkisi sonucunda modifiye olduğu ve bu şekilde makrofajlar tarafından daha hızlı içeri alındığı gösterilmiştir. LDL’de meydana gelen bu modifikasyonun aterosklerozun başlamasında ve gelişiminde en önemli faktör olduğu kabul edilmektedir. Okside-LDL (Ox-LDL) partikülleri kemotaktik, sitotoksik ve immünojenik özellik gösterirler. Ox-LDL sayısız epitopa sahiptir ve bunlara karşı poliklonal antikor üretimine neden olur. Özellikle malondialdehit (MDA) ve 4-hidroksinonenal ile modifiye olmuş apolipoprotein B100 (apoB100)’e karşı antikorlar oluşur. Ig-OxLDL ateroskleroz oluşumuna katkıda bulunuyor olabilir. Ox-LDL’ye karşı antikorlar ateroskleroz dışında koroner arter hastalığı (KAH), diabetes mellitus (DM), renovasküler sendrom, üremi, akut enfeksiyon, preeklampsi, antifosfolipid sendromu (APS), metabolik sendrom (MS), miyokard infarktüsü (MI) ve sistemik lupus eritematozus (SLE) gibi pek çok hastalıkta da bulunmuştur. Bu otoantikorlar başta ateroskleroz ve KAH olmak üzere birçok hastalığın patogenezinde ve tanısında önemli olabilirler. Fakat, bu antikorlar oldukça heterojen bir grup olup hakkındaki bilgilerimiz çok az ve yetersizdir. Bu derlemedeki amacımız, Ox-LDL hakkındaki bilgilerimizi irdelemektir.Öğe Osteoprotegerin, Rank ve Rank Ligandı(2007) Kurban, Sevil; Mehmetoğlu, İdrisOsteoprotegerin, reseptör aktivatör nükleer kappa B ve reseptör aktivatör nükleer kappa B ligand’ın keşfi ve osteoklastojenezisteki rollerinin belirlenmesi kemik biyolojisinin anlaşılmasına çok önemli katkılar sağlamıştır. Reseptör aktivatör nükleer kappa B ligand preosteoklastların üzerindeki reseptörü reseptör aktivatör nükleer kappa B’e bağlanarak, onların osteoklastlara dönüşmesini uyarır ve böylece kemik rezorpsiyonu oluşur. Osteoprotegerin ise reseptör aktivatör nükleer kappa B ligand için yalancı reseptör görevi görür ve kemik rezorpsiyonunu inhibe eder. Kemik biyolojisinin anlaşılmasına sağladıkları bu temel bakış açısı dışında osteoprotegerin, reseptör aktivatör nükleer kappa B ve reseptör aktivatör nükleer kappa B ligand’ın immün sistem, arteryel kalsifikasyon ve pek çok metabolik kemik hastalığı ile de ilgili olabilecekleri belirtilmiştir. Bu derlemede osteoprotegerin, reseptör aktivatör nükleer kappa B ve reseptör aktivatör nükleer kappa B ligand’ın kemik rezorpsiyonu, immün sistem ve arteryel kalsifikasyondaki rolünün ve tedavideki yerinin özetlenmesi amaçlanmıştır.Öğe Oxidative Stress in Mothers and Their Newborns in Different Types of Labour(2002) Mehmetoğlu, İdris; Kart, Ali; Çağlayan, Osman; Çapar, Metin; Gökçe, Recep[Abstract not Available]Öğe Oxidative Stress Markers in Hemodialysis and Peritoneal Dialysis Patients, Including Coenzyme Q10 and Ischemia-Modified Albumin(WICHTIG EDITORE, 2012) Mehmetoğlu, İdris; Yerlikaya, F. Hümeyra; Kurban, Sevil; Erdem, S. Sami; Tonbul, ZekiObjectives: Oxidative stress results from an imbalance between the production of free radicals and antioxidant activity. There is wide agreement that patients undergoing regular dialysis treatment experience increased oxidative stress. The aim of this study was to investigate serum total antioxidant status (TAS), total oxidant status (TOS), ischemia-modified albumin (IMA), and coenzyme Q(10)(CoQ(10)) levels in hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) patients, compared with controls. Methods: This study was performed on 41 (21 men, 20 women) CAPD patients, 38 (20 men, 18 women) HD patients, and 43 (23 men, 20 women) healthy control subjects. CoQ(10) levels were standardized using blood lipids. Results: Serum TAS levels and CoQ(10)/total cholesterol values of the HD and CAPD patients were significantly lower, whereas serum IMA and TOS levels were significantly higher, than those of controls. Furthermore, CoQ(10)/LDL, CoQ(10)/triglycerides, and CoQ(10)/total cholesterol + triglycerides values of the CAPD patients were significantly lower than those of controls. No differences were found between serum IMA, TAS, TOS, CoQ(10) levels, and adjusted CoQ(10) values of the CAPD and HD patients. Conclusions: Our results suggest that oxidative stress is increased in HD and CAPD patients compared with controls, as proven by decreased TAS and adjusted CoQ(10) levels and increased TOS and IMA levels. Therefore, an antioxidant supplementation to these patients may be suggested.Öğe Procalcitonin measurement at 24 hours of age may be helpful in the prompt diagnosis of early-onset neonatal sepsis(ELSEVIER SCI LTD, 2011) Altunhan, Hüseyin; Annagür, Ali; Örs, Rahmi; Mehmetoğlu, İdrisBackground: The clinical signs of early-onset neonatal sepsis (EONS) are nonspecific and indistinguishable from those of noninfectious disorders. The early diagnosis of EONS is difficult, but is essential to improve outcomes. The aim of this study was to determine the diagnostic value of procalcitonin (PCT) at birth and at 24 h of age in the prompt diagnosis of EONS. Methods: The patient group consisted of neonates with a Tollner score of >= 10 or a Tollner score of 5-10 but with the presence of prolonged rupture of the membranes (>18 h) or chorioamnionitis or maternal fever (n = 171). The control group (n = 89) comprised neonates admitted to the neonatal intensive care unit for different disease entities. Procalcitonin levels at birth (first) and at 24 h of age (second) were measured for each neonate in both of the study groups. Results: There was no difference between the two groups in terms of gender, birth weight, or gestational age. The mean (min-max) first PCT level was 0.48 (0.07-3.48) ng/ml in the controls and 0.51 (0.09-28.6) ng/ml in patients. The mean (min-max) second PCT level was 1.72 (0.21-18.23) ng/ml in the controls and 16.17 (0.17-100) ng/ml in patients. There was no statistically significant difference in PCT levels between the patient and control groups at birth. However, at 24 h of age, PCT levels were significantly higher in the patient group than in the control group (p < 0.001). Serum PCT levels in controls at 24 h of age were slightly increased compared to levels at birth, but as a normal reaction. PCT thresholds for the diagnosis of sepsis were 0.59 ng/ml at birth (sensitivity 48.7%, specificity 68.6%) and 5.38 ng/ml at 24 h of life (sensitivity 83.3%, specificity 88.6%). Conclusions: In EONS, PCT measurements at birth may initially be normal; a serial PCT measurement at 24 h of age may be more helpful for an early diagnosis. During the first 24 h of life PCT is a more sensitive marker of infection than C-reactive protein. Further studies are needed to confirm our findings. (C) 2011 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
