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Öğe Both hypothyroidism and hyperthyroidism increase plasma irisin levels in rats(WALTER DE GRUYTER GMBH, 2018) Atıcı, Emine; Moğulkoç, Rasim; Baltacı, Abdülkerim Kasım; Menevşe, EsmaBackground: A recently discovered hormone, irisin is accepted to be significantly involved in the regulation of body weight. Thyroid functions may be, directly or indirectly, associated with irisin. Aim: The aim of the present study is to determine the effect of experimental thyroid dysfunction on irisin levels in rats. Methods: The study registered 40 adult male Sprague-Dawley rats, which were allocated to groups as follows: 1. Control; 2. Hypothyroidism induced by injection of 10 mg/kg/day intraperitoneal propylthiouracil (PTU) for 3 weeks; 3. Hypothyroidism (PTU 2 weeks) + L-thyroxin (1.5 mg/kg/day for 1 week); 4. Hyperthyroidism induced in rats by 3-week thyroxin (0.3 mg/kg/day); 5. Hyperthyroidism + PTU. At the end of the study, blood samples were collected to quantify free triiodothyronine (FT3), free triiodothyronine (FT4) and irisin levels. Results: FT3 and FT4 levels were reduced in hypothyroidism and were significantly elevated in hyperthyroidism (p < 0.001). Irisin values, on the other hand, were found to be elevated in both hypothyroidism and hyperthyroidism groups (p < 0.001). Conclusion: The results of the study suggest that irisin values increase in thyroid dysfunction, hypo-and hyperthyroidism, and that when hypothyroidism is corrected by thyroxin administration and hyperthyroidism by PTU injection, plasma irisin values go back to normal.Öğe The effect of 3 ', 4 '-dihydroxyflavonol on lipid peroxidation in brain ischemia-reperfusion damage in rat(WILEY-BLACKWELL, 2015) Çalışkan, Merve; Moğulkoç, Rasim; Baltacı, Abdülkerim Kasım; Menevşe, Esma; Ergene, Neyhan[Abstract not Available]Öğe The Effect of 3 ',4 '-Dihydroxyflavonol on Lipid Peroxidation in Rats with Cerebral Ischemia Reperfusion Injury(SPRINGER/PLENUM PUBLISHERS, 2016) Çalışkan, Merve; Moğulkoç, Rasim; Baltacı, Abdülkerim Kasım; Menevşe, EsmaThe aim of present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on lipid peroxidation in experimental brain ischemia-reperfusion in rats. Present study was performed on the 34 male Wistar-albino rats, weigth 350-400 g. Experiment groups were designed as 1-Sham; 2-Ischemia-reperfusion; animal were anesthesized and carotid arteried were clemped for 20 min and reperfusion (7 days). 3-DiOHF + Ischemia-reperfusion; DiOHF was given to animals as 10 mg/kg by intraperitoneal. 4- Ischemia + DiOHF + Reperfusion; 5- Ischemia-reperfusion + DiOHF. Blood samples and serebral cortex were analysed for malondyaldehyde (MDA), NO (nitric oxide), xanthine oxidase (XO), glutathione (GSH) and glutathione peroxidase (GPx). Blood MDA levels were significantly higher ischemia-reperfusion groups (P < 0.005). However, DiOHF inhibited MDA. Ischemia-reperfusion led to increased XO and NO but DiOHF supplementation reduced NO and XO. DiOHF increased GSH and GPx levels compared to ischemia-reperfusion group. All together, our present study showed that intraperitoneal DiOHF supplementation has protective effect on brain ischaemia-reperfusion injury in rat.Öğe The Effect of Pinealectomy and Melatonin Supplementation on Serum Melatonin, Nesfatin-1 and Ghrelin Levels in Rats(KARGER, 2018) Sönmez, Saadet; Baltacı, Abdülkerim Kasım; Baltacı, Saltuk Buğra; Moğulkoç, Rasim; Menevşe, Esma[Abstract not Available]Öğe The Effect of the Application of Melatonin and Zinc in DMBA-Induced Mammary Carcinoma in Rats on Lipid Peroxidation and Element Metabolism(KARGER, 2018) Mutlu, Elif Gülbahçe; Baltacı, Saltuk Buğra; Menevşe, Esma; Moğulkoç, Rasim; Baltacı, Abdülkerim Kasım[Abstract not Available]Öğe The effect of thyroid dysfunction on nesfatin-1 and adiponectin levels in rats(WALTER DE GRUYTER GMBH, 2017) Atıcı, Emine; Moğulkoç, Rasim; Baltacı, Abdülkerim Kasım; Menevşe, EsmaBackground: Changes in thyroid hormone concentrations may affect adiponectin concentrations through various mechanisms. A molecule released primarily from the fat cells adiposities; adiponectin has important effects on the regulation of body weight. Aim: The present study aimed to explore the effects of experimental thyroid dysfunction and its treatment on nesfatin-1 and adiponectin levels in rats. Methods: The study included 40 adult male Sprague-Dawley rats which were grouped as follows: (1) control; (2) hypothyroidism [hypothyroidism was induced by intraperitoneal injection of 10 mg/kg/day propylthiouracil (PTU) for 3 weeks]; (3) hypothyroidism + thyroxine group [after hypothyroidism was induced by 2-week PTU injection, they were treated with high-dose L-thyroxine (1.5 mg/kg/day) for 1 week]; (4) hyperthyroidism [hyperthyroidism was induced by 3-weeks' thyroxine injection (0.3 mg/kg/day)]; (5) hyperthyroidism + PTU (after hyperthyroidism was induced by 2-weeks' thyroxine injection, the animals were given 10 mg/kg/day PTU for 1 week). Blood samples taken at the end of the study were analyzed to measure nesfatin-1 and adiponectin levels. Results: It was found that nesfatin-1 levels increased in hypothyroidism, while adiponectin levels decreased (p < 0.001). In experimental hyperthyroidism, on the other hand, both nesfatin-1 and adiponectin levels were found significantly elevated (p < 0.001). Conclusion: The results of the study indicate that nesfatin-1 and adiponectin levels were modified considerably in hypo- and hyperthyroidism, whereas with the restoration of the thyroid function, modified hormone levels went back to normal.Öğe The effects of ankaferd blood stopper on DNA damage and enzymes with paranchymal damaged rabbits(2017) Metin, Bayram; Menevşe, Esma; Sivrikaya, Abdullah; Altınok, Tamer; Arıkoğlu, HilalAnkaferd blood stopper (ABS) is a medical product that is used in several injuries, dental operations, prevention of minor or major bleeding after spontaneous or surgerical operations and have anti-microbial, anti-inflamatory, anti-thrombin, anti-platelet, anti-atherosclerotic, anti-oxidants effects. The present study is aimed to evaluate the effects of ABS on 8-hydroxy-2?-deoxyguanosine (8-OHdG), superoxide dismutase (SOD), myeloperoxidase (MPO) levels over pleural adhesions in rabbits with pulmonary parenchymal damage.16 New Zelland species rabbits were divided in two groups such as control (n7) and study group (n7). One rabbit in each group died during anesthesia. In both groups, we performed wedge resections in equal size to the left lower lobes of all rabbits. No interventions were made on control group, whereas 5 puff’s (1 cc) ABS was performed to the resection area at study group. Tube thoracostomy that performed both groups were terminated postoperatively at 6th hour after drainage and air leakages follow up. Rabbits were sacrificed with anesthetics at postoperative 8th day. Lung tissues were collected for analyzing of 8-OHdG, SOD, MPO. The 8-OHdG levels were respectively 2.010.39 ng/ml in control group and, 0.380.12 ng/ml in study. The differences between study and control group were statistically important group (p0.001). SOD and MPO levels did not show any statistically importance in the groups. As a conclusion, we can say that oxidative DNA damage prevented by ABSÖğe Evaluation of the effects of ankaferd blood stopper on rabbits with paranchyme damage: an experimental study(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2013) Metin, Bayram; Altınok, Tamer; Menevşe, Esma; Esen, HasanBackground: In this study, we aimed to evaluate the effects of Ankaferd Blood Stopper (ABS), a herbal extract used as a hemostatic agent in traditional Turkish medicine, on hemostasis, wound healing, air leakage and the efficiency over pleural adhesions in rabbits with pulmonary parenchymal damage. Methods: Sixteen New Zelland Albino type male and female rabbits with a mean weight of 2500 g were used. The rabbits were divided into two groups as study group and control group. One rabbit in each group died during anesthesia. We performed wedge resections in equal size to the left lower lobes of all rabbits. No additional procedure was performed on the control group, while the study group received 5 puffs (similar to 1 cc) of ABS to the resection area. Tube thoracostomy, which was performed in both groups, was terminated postoperatively at the sixth hours after drainage and air leakage follow-up. The rabbits were sacrificed with high dose anesthetic at the postoperative eight-day. Pleural inflammation and fibrosis in the hemithorax were examined macroscopically and microscopically. Biochemical measurements of tissue malondialdehyde (MDA) and hydroxyprolin (HPR) levels were done. Results: There was a statistically significant difference in postoperative air leakage and the amount of drainage between the groups (amount of hemorrhage p<0.05, air leakage p<0.001). A higher rate of macroscopic and microscopic fibrosis was observed in the study group. When both groups are compared according to tissue MDA levels, decreased MDA level was seen in the group which ABS was administered, where the difference was statistically non-significant. Conclusion: Ankaferd Blood Stopper reduces postoperative bleeding and prolonged air leakages without any toxic effects and has an effective role at pleurodesis, increasing the pleural fibrosis level.Öğe Is there any association between serum iron and copper levels in hemadialysis patients?(2009) Sivrikaya, Abdullah; Menevşe, Esma; Tiftik, Ali Muhtar; Tonbul, ZekiÇalışmanın amacı, hemodiyaliz hastalarında serum demir (Fe), bakır (Cu) ve ferritin düzeylerindeki değişiklikleri tespit etmek ve ferritin düzeyleri ile elementler arasında bir ilişkinin olup olmadığını belirtmekti. Çalışmaya 2-16 yıldır diyalize giren (yaş ortalaması 50.2616.36) 47 hemodiyaliz hastası (hemodiyaliz grubu) ve 23 sağlıklı kişi (yaş ortalaması 39.52ill.54) (kontrol grubu) dâhil edildi. Hemodiyaliz grubunda kan numuneleri diyaliz öncesi ve sonrası alındı. Veriler, gruplar arasında serum Fe düzeyleri bakımından önemli bir fark bulunmadığını gösterdi. Ancak, diyaliz öncesi Cu düzeyleri ve de diyaliz öncesi ve sonrası ferritin düzeyleri kontrol grubuna göre daha yüksekti (sırasıyla p0.05, p0.001). Diyaliz öncesi ferritin-Fe (r 0.373, p0.05) ve Fe-Cu (r 0.410, p0.01) düzeyleri arasında önemli pozitif korelasyon bulundu. Bu çalışmadan elde edilen bulgular, serum Cu düzeylerindeki değişikliklerin hemodiyaliz hastalarında önemli olabileceğini düşündürmektedir. Bununla birlikte, Cu ve Fe arasındaki korelasyon bu elementler arasında bir ilişkinin olduğunu göstermektedir. Fe ile Cu arasındaki ilişkinin aydınlanması için daha ileri çalışmalara ihtiyaç vardır.Öğe Levels of Plasma NPY, Leptin and Nesfatin-1, and Their Relation to Zinc in Children with Obese and Metabolic Syndrome(KARGER, 2018) Aydoğdu, Adnan; Baltacı, Abdülkerim Kasım; Menevşe, Esma; Baltacı, Saltuk Buğra; Moğulkoç, Rasim; Erdem, Said Sami; Büyükinan, Muammer[Abstract not Available]Öğe Pulmoner parenkim hasarı yapılan tavşanlarda ankaferd blood stopper uygulamasının etkileri: Deneysel bir çalışma(2013) Metin, Bayram; Altınok, Tamer; Menevşe, Esma; Esen, HasanAmaç: Çalışmada pulmoner parenkim hasarı yapılan tavşanlarda, geleneksel Türk hekimliğinde hemostatik ajan olarak kullanılmış bir bitkisel ekstrakt olan Ankaferd Blood Stopper’in (ABS) kanama kontrolü, yara iyileşmesi, hava kaçağı ve plevral yapışıklık üzerindeki etkinliği değerlendirildi. Çalışma planı: Ortalama ağırlıkları 2500 gr olan 16 adet Yeni Zelanda Albino türü erkek ve dişi tavşan kullanıldı. Tavşanlar çalışma ve kontrol grubu olarak iki gruba ayrıldı. Her iki grupta birer tavşan anestezi sırasında öldü. Tüm tavşanların sol alt loblarına eşit büyüklükte kama rezeksiyon yapıldı. Çalışma grubunda rezeksiyon alanına 5 puf (1 cc) ABS sprey uygulanır iken, kontrol grubuna ek bir işlem yapılmadı. İki gruba da uygulanan tüp torakostomi, ameliyat sonrası altı saat drenaj ve hava kaçağı takibi sonrası sonlandırıldı. Ameliyat sonrası sekizinci gün tavşanlar yüksek doz anestezi ile sakrifiye edildi. Hemitorakstaki plevral enflamasyon ve fibrozis makroskopik ve mikroskopik olarak incelendi. Doku malondialdehit (MDA) ve hidroksiprolin (HPR) düzeylerinin biyokimyasal ölçümleri yapıldı. Bulgular: Ameliyat sonrası hava kaçağı ve drenaj miktarı açısından iki grup arasındaki fark istatistiksel olarak anlamlı idi (kanama miktarı p0.05, hava kaçağı p0.001). Çalışma grubunda makroskopik ve mikroskopik fibrozis yüksek düzeyde gözlendi (p0.0001). Doku MDA düzeyleri bakımından iki grup karşılaştırıldığında, ABS uygulanan grupta MDA düzeyinin düştüğü görülmek ile birlikte, fark istatistiksel açıdan anlamlı değil idi. Sonuç: Ankaferd Blood Stopper toksik etkiye yol açmadan ameliyat sonrası kanamaları ve uzamış hava kaçaklarını azaltmakta ve plevral fibrozis düzeyini artırarak plörodezde etkin rol oynamaktadır.Öğe The Relations Between Levels of Cadmium and Thyroid Parameters in Hemodialysis Patients(2013) Sivrikaya, Abdullah; Menevşe, Esma; Altıntepe, Lütfullah; Tifti, Ali MuhtarAmaç: Sunulan çalışmanın amacı, hemodiyaliz ve sağlıklı kişilerde serum kadmiyum (Cd), total triiyodotironin (T3), total tiroksin (T4) ve adrenokor- tikotropik hormon (ACTH) düzeyleri arasında istatistiksel olarak farklılık ve de gruplar arasında bu eser element ile tiroit profilleri ve ACTH arasında korelasyon olup olmadığını değerlendirmekti. Gereç ve Yöntem: Çalışmaya 2-16 yıldır haftada en az üç kez diyalize giren, her seansı en az 4 saat olan 47 hemodiyaliz hastası (hemodiyaliz grubu) ve 23 sağlıklı kişi (kontrol grubu) dahil edildi. Hemodiyaliz grubunda kan numuneleri diyaliz öncesi ve sonrası alındı. Kontrol grubunun kan numuneleri 10 saatlik açlık sonrası alındı. Bul- gular: Total T3 (p0.001) düzeyleri kontrol grubunda diyaliz öncesi ve diyaliz sonrasına göre daha yüksekti. Total T3 (p0.05) düzeyleri diyaliz öncesi diya- liz sonrasına göre daha düşüktü. Kontrol grubunda Total T4 düzeyleri yüksek, Cd düzeyleri ise düşük tespit edildi. Bu parametreler, diyaliz öncesine göre ise, istatistiksel açıdan önemli farklılık (sırasıyla p0.001, p0.01) gösterdi. ACTH düzeyleri bakımından gruplar arasında önemli bir farklılık bulunmadı. Tartışma: Hemodiyaliz hastalarında Cd düzeylerinin ölçülmesinin önemli ola- bileceği kanısındayız. Ancak Cd, tiroit profilleri ve ACTH düzeyleri arasında önemli bir ilişki bulamadık.Öğe The Relations Between Levels of Cadmium and Thyroid Parameters in Hemodialysis Patients(Derman Medical Publishing, 2013) Sivrikaya, Abdullah; Menevşe, Esma; Altıntepe, Lütfullah; Tiftik, Ali MuhtarThe aim of the present study is to determine whether there are statisti-cally differences between hemodialysis patients and control (healthy) groups according to level of serum cadmium (Cd), total triiodothyronine (T3) and total thyroxine (T4) and adrenocorticotropin hormone (ACTH), and besides whether there are any correlation coefficients of trace element with thyroid profiles, ACTH in these groups. Material and Methods: The study included 47 hemodialysis patient who were dialyzed three times a week and each session was at least 4 hours. The duration of dialysis range were 2-16 yr. This gro-up called as a "Hemodialyis group". Blood samples were taken before (pre-hemodialysis) and after (post-hemodialysis) hemodialysis session. "Control group" included 23 healthy volunteers with no medical problem. In control group, samples were taken after 10 hour fasting. Results: Levels of total T3 were higher in group of control than the levels of pre-hemodialysis and post-hemodialysis (p?0.001). Total T3 levels were lower in pre-hemodialysis (p?0.05) than those of post-hemodialysis. The highest level of total T4 and lowest level of Cd were in control group and these parameters were statisti-cally different from the pre-hemodialysis (respectively p?0.001, p?0.01). We did not determine any significant differences between all groups according to data of ACTH levels. Discussion: We suggest that analyzing the levels of Cd may be useful for the hemodialysis patients. But, we did not determine a significant association between Cd and thyroid profiles and ACTH levels.Öğe Selenium supplementation prevents lipid peroxidation caused by arduous exercise in rat brain tissue(COMENIUS UNIV, 2011) Akil, Mustafa; Biçer, Mürsel; Menevşe, Esma; Baltacı, Abdulkerim Kasım; Moğulkoç, RasimBackground: The objective of the present study is to examine how selenium supplementation affects lipid peroxidation in the brain tissue of rats subjected to acute swimming exercise. Methods: The study was carried out on 32 Spraque-Dawley adult male rats, which were allocated equally to four groups, namely general control (Group 1), selenium-supplemented control (0.6 mg/kg/day sodium selenite) (Group 2), swimming control (Group 3), and selenium-supplemented swimming group (6 mg/kg/day sodium selenite) (Group 4). Selenium supplementations were carried out by intraperitoneal (i.p.) route for four weeks. At the end of supplementation, animals in groups 3 and 4 were subjected to acute swimming. Brain tissue samples were collected from decapitated animals to determine malondialdehyde (MDA) levels using a spectrophotometer according to "Schimadzu-1601, Japan" Uchiyama and Mihara and GSH levels using a spectrophotometer according to Ellmann. Results: The highest MDA values in the brain tissue were obtained in Group 3 (p<0.001). MDA values in Group 4 were higher than those in Groups 1 and 2 (p<0.001). Brain tissue MDA values in Groups 1 and 2 did not differ. Group 4 had the highest brain GSH levels (p<0.001). Brain tissue glutathione (GSH) levels in Group 3 were higher than those in Groups 1 and 2 (p<0.001). Conclusion: Results of the study indicate that acute swimming exercise in rats increased the lipid peroxidation in the brain tissue of rats, while selenium supplementation prevented the free-radical formation by enhancing the antioxidant activity (Tab. 1, Ref. 24). 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