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    Application of L-Proline Derivatives as Chiral Shift Reagents for Enantiomeric Recognition of Carboxylic Acids
    (WILEY, 2011) Naziroglu, Hayriye Nevin; Durmaz, Mustafa; Bozkurt, Selahattin; Sirit, Abdulkadir
    Four proline-derived chiral receptors 5-8 were readily synthesized starting from L-proline. The enantiomeric recognition ability of chiral receptors was examined with a series of carboxylic acids by H-1 NMR spectroscopy. The molar ratio and the association constants of the chiral compounds with each of the enantiomers of guest molecules were determined by using Job plots and a nonlinear least-squares fitting method, respectively. The Job plots indicate that the hosts form 1:1 instantaneous complexes with all guests. The receptors exhibited different chiral recognition abilities toward the enantiomers of racemic guests. Among the chiral receptors used in this study, prolinamide 6 was found to be the best chiral shift reagent and is effective for the determination of the enantiomeric excess of chiral carboxylic acids. Chirality 23:463-471, 2011. (C) 2011 Wiley-Liss, Inc.