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Öğe Chemical Composition and Antibacterial Activity of the Essential Oil of a 1,8-Cineole Chemotype of Mentha aquatica L. Growing Wild in Turkey(2005) Senatore, Felice; D’Alessio, Andrea; Formisano, Carmen; Özcan, MusaThe essential oil from aerial parts of Mentha aquatica L. (Lamiaceae) was obtained by hydrodistillation. The oil content was 0.37% (v/w), on a dry weight basis. The oil composition was analyzed by GC and GC/MS. Altogether 31 compounds were identified accounting for 93.2% of the oil. 1,8-cineole (55.3%) was the most abundant component with appreciable amounts of carvacrol (9.3%) and sabinene (6.7%). The oil shows an interesting antibacterial activity, mostly against Gram + bacteria.Öğe Composition and Antibacterial Activity of the Essential Oil From Crithmum Maritimum L. (Apiaceae) Growing Wild in Turkey(John Wiley & Sons Ltd, 2000) Senatore, Felice; Napolitano, Franesco; Özcan, MusaThe essential oil from aerial parts of Crithmum maritimum L. (Apiaceae) growing wild in Antalya and Mersin, Turkey, was isolated by hydrodistillation and obtained in a yield of 0.17 and 0.19% (v/f w), respectively. The oil composition was analyzed by GC and GC-MS. Nineteen and twenty one compounds, accounting for 98 and 97% of the oils, were identified. The former oil was characterized by a high content of beta -phellandrene (30%) and thymol methyl ether (25%), the latter by gamma -terpinene (24%) and dill-apiole (21%). Evaluation of the antibacterial activity showed that the oils have a similar, appreciable activity, mostly against Gram + bacteria.Öğe Composition of the Essential Oil of Nepeta Betonicifolia C.A. Meyer (Lamiaceae) From Turkey(Allured Publ Corp, 2003) Senatore, Felice; Özcan, MusaThe essential oil of Nepeta betonicifolia L. (Lamiaceae) grown in Turkey obtained by hydrodistillation of aerial parts was analyzed by GC/MS. Thirty-four compounds were identified constituting 89.6% of the oil, the major Components being linalool (40.5%), 1,8-cineole (20.8%), and caryophyllene oxide (9.2%). No nepetalactones were found as oil constituents.Öğe Daphne oleoides: An alternative source of important sesquiterpenes(TAYLOR & FRANCIS INC, 2017) Uysal, Ahmet; Zengin, Gökhan; Aktümsek, Abdurrahman; Rigano, Daniela; Senatore, Felice; Şanda, Murad AydınThis study was targeted to characterize the chemical composition and antibacterial properties of Daphne oleoides subsp. oleoides essential oil. The essential oil was analyzed and quantified by gas chromatography and gas chromatography/mass spectrometry. Additionally, the broth dilution method was used to evaluate its antibacterial activity against Bacillus cereus (ATCC 11778), Bacillus subtilis (ATCC 6633), Staphylococcus aureus (ATCC 25923), Staphylococcus epidermidis (ATCC 12228), Streptococcus faecalis (ATTC 29212), Escherichia coli (ATCC 25922), Proteus mirabilis (ATCC 25933), Proteus vulgaris (ATCC 13315), Pseudomonas aeruginosa (ATCC 27853), and Salmonella typhi Ty2 (ATCC 19430). Seventy-nine compounds were identified, representing 95.2% of the total oil. Nootkatone (18.5%), nootkatin (12.1%), and daphnauranol C (11.7%) were determined as the main constituents in the oil. Oxygenated sesquiterpenes were dominating in the oil (43.0%), followed by fatty acid derivatives (13.7%) and carbonylic compounds (9.6%). The minimal inhibitory/bactericidal concentrations of essential oils of D. oleoides were in the range from 25-100 g/mL, which can be considered as high activity in comparison with the reference antibiotic which was active in the rangefrom 3.12-100 g/mL. The greatest minimal inhibitory concentration value was determined as 25 mu g/mL against both two Bacillus strains and S. epidermidis, B. cereus, B. subtilis, and S. aureus were the most sensitive strains against essential oils when compared with the minimal inhibitory concentrations of control antibiotic. Consequently, Daphne oleoides subsp. oleoides can be exploited as a source of natural antibacterial agents and nootkatone for the pharmaceutical, food, and agricultural industries.Öğe Effect of Three Centaurea Species Collected from Central Anatolia Region of Turkey on Human Melanoma Cells(NATURAL PRODUCTS INC, 2016) Russo, Alessandra; Cardile, Venera; Graziano, Adriana C. E.; Rigano, Daniela; Aktümsek, Abdurrahman; Zengin, Gökhan; Senatore, FeliceCentaurea is the largest genus within the Asteraceae family. Many members of this genus are used in traditional folk medicine, such as Centaurea pulchella used to treat skin problems such as to resolve the abscess. Although biological activities of many Centaurea species have been investigated in different countries and Turkey, cytotoxic effect of C. patula, C. pulchella and C. tchihatcheffii has not been studied yet. Melanoma is one of the most invasive and deadly forms of skin cancer. Therefore, in an ongoing effort to identify new natural anticancer products for the treatment and/or prevention of melanoma cancer, the present study was undertaken to investigate the effect of these Centaurea species, collected from Central Anatolia region of Turkey on cell growth and death in human melanoma cell line, A375. The results revealed that all extracts were able to inhibit, after 48 h of treatment, the growth of cancer cells, that could be related to an overall action of the phenolic compounds present. In fact, C. pulchella, with the highest level of phenolics, showed a major activity followed by C. patula and C. tchihatcheffii. Our data also demonstrate that these natural products induce apoptotic cell death. In conclusion, the study of plant extracts for their cytotoxic and apoptotic properties has shown that medicinal herbs from Centaurea species might have also importance in the prevention and treatment of melanoma.
