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    Association between RDW and stent thrombosis in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention
    (LIPPINCOTT WILLIAMS & WILKINS, 2017) Tuncez, Abdullah; Cetin, Mehmet Serkan; Cetin, Elif Hande Ozcan; Yilmaz, Samet; Korkmaz, Ahmet; Ucar, Fatih Mehmet
    Stent thrombosis is a rare but potentially fatal complication of percutaneous coronary interventions (PCIs). In recent years, the predictive and prognostic value of the red cell distribution width (RDW) as an indicator of inflammation has been shown in many cardiovascular diseases. Aim of this study was to examine the predictive value of RDW for stent thrombosis in patients who underwent successful stent implantation for ST-elevation myocardial infarction (STEMI). In this retrospective study, 146 patients who underwent successful PCI to native coronary artery due to STEMI previously and presented with acute coronary syndrome with stent thrombosis were included (stent thrombosis group). A total of 175 patients who had similar procedural characteristics (type, diameter, and length of stent) and not had stent thrombosis were consisted control group. Patients were divided into tertiles according to the admission RDW values (12.9 +/- 0.4, 14.2 +/- 0.4, and 16.3 +/- 1.5, respectively). Stent thrombosis developed in 47 (40.9%) patients in the lowest tertile, 39 (37.9%) patients in mid tertile, and 60 (58.3%) patients in the highest tertile (P=0.006). Female gender ratio was statistically significantly higher in the 3rd tertile (13 [11.3%], 8 [7.8%], 24 [23.3%], P=0.003, respectively). RDW (OR: 1.397 [95% CI 1.177-1.657], P<0.001) and platelet count (OR: 1.008 [95% CI 1.004-1.012], P<0.001) remained independent predictors of stent thrombosis after multivariate logistic regression analysis. ROC curve analysis demonstrated that, admission RDW values higher than 13.9 can predict the development of stent thrombosis with a sensitivity of 57% and a specificity of 52% (The area under the ROC curve: 0.59 [95% CI 0.53-0.65] P=0.007). High RDW values found to be independently associated with the development of stent thrombosis in patients with STEMI. Abbreviations: LDL = low-density lipoprotein, PCI = percutaneous coronary intervention, RDW = red cell distribution width, STEMI = ST-elevation myocardial infarction.
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    Comparative effects of atorvastatin 80 mg versus rosuvastatin 40 mg on the neutrophil to lymphocyte ratio, platelet to lymphocyte ratio and monocyte to hdl-cholesterol ratio in patients with acute myocardial infarction
    (2019) Tuncez, Abdullah
    Background: Previous studies have shown the association between the elevated levels of hematological markers like Neutrophilto Lymphocyte ratio (NLR), Platelet to lymphocyte ratio (PLR) and Monocyte to High density lipoprotein cholesterol (HDL-C) ratio(MHR) and increased risk of the existence of cardiovascular disease, increased risk of acute coronary syndromes and severity ofcardiovascular disease. One of the most commonly used drugs in atherosclerotic cardiovascular diseases are statins and we knowthat statins have beneficial effects in addition to LDL-lowering effects known as pleiotropic effects. However the effects of statinson the hematological markers are unclear. We performed this investigation to clarify and compare the effects of maximum-dose ofatorvastatin and rosuvastatin on hematological biomarkers in patients with acute myocardial infarction.Methods: Statin or other anti-lipid drugs naive patients with either ST-segment elevation myocardial infarction or Non-ST elevationmyocardial infarction were enrolled to our study. Biochemistry parameters, lipid parameters, blood-count parameters and NLR, PLRand MHR levels were measured at baseline and 30 days after discharge. Baseline characteristics and results of 2 groups after onemonthtreatment were compared.Results: Among the 128 statin-naive patients included, 65 patients received atorvastatin (80 mg/day) and 63 patients recievedrosuvastatin (40 mg/day). Baseline clinical characteristics of groups were similar. Atorvastatin 80 mg significantly decreased thelevels of NLR (p0.001) and MHR (p0.024) at the end of one-month therapy. Rosuvastatin 40 mg also significantly decreased thelevels of NLR (p0.001) and MHR (p0.006) at the end of one-month therapy. Both statins were ineffective on the levels of PLR.Percent and absolute changes of NLR, MHR and PLR were similar and there were no statistically significant differences between bothgroups. The percent and absolute changes of lipid parameters were also similar among both treatment arms.Conclusion: Our results showed that atorvastatin 80 mg and rosuvastatin 40 mg decreased the NLR and MHR levels significantly atthe end of one-month therapy. However, both statins have no effects on PLR levels.
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    COMPARATIVE EFFECTS OF HIGH-DOSE ATORVASTATIN VERSUS ROSUVASTATIN ON LIPID PARAMETERS, OXIDIZED-LDL AND PCSK9 LEVELS IN ACUTE CORONARY SYNDROME
    (ELSEVIER IRELAND LTD, 2018) Yalçın, Meryem Ülkü; Altunkeser, Bülent Behlül; Tuncez, Abdullah; Öztürk, Bahadır; Tezcan, Hüseyin; Ateş, Muhammet S.; Yılmaz, Canan
    [Abstract not Available]
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    Incidence and Predictors of Radial Artery Occlusion
    (H M P COMMUNICATIONS, 2015) Tuncez, Abdullah; Avci, Ahmet; Demir, Kenan
    [Abstract not Available]
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    Letter by Tuncez et al Regarding Article, "MacCallum Plaque Causes Acute Myocardial Infarction in a Young Man"
    (LIPPINCOTT WILLIAMS & WILKINS, 2015) Tuncez, Abdullah; Demir, Kenan; Avci, Ahmet
    [Abstract not Available]
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    Letter by Tuncez et al Regarding Article, "The Forgotten Valve: Isolated Severe Tricuspid Valve Stenosis"
    (LIPPINCOTT WILLIAMS & WILKINS, 2016) Tuncez, Abdullah; Demir, Kenan; Avci, Ahmet
    [Abstract not Available]
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    Ultrasound vs Angiography for Drug-Eluting Stent Implantation
    (AMER MEDICAL ASSOC, 2016) Tuncez, Abdullah; Altunkeser, Bülent Behlül
    [Abstract not Available]