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Evaluation of the Biocompatibility of Various Self-Adhesive Resin Cements on Subcutaneous Connective Tissue: An in Vivo Study
(Selçuk Üniversitesi, 2023 Ağustos) Gerçek, Anıl; Turhan Bal, Bilge; Barış, Emre
Background: The purpose of the study was to examine the subcutaneous connective tissue reaction to three self-adhesive resin cements. Methods: Sixty-three polyethylene tubes were filled with three different self-adhesive resin cements (Group Z [Zirconite], Group P [Panavia SA], and Group H [High Q Bond]). Twenty-one polyethylene tubes remained empty and were used as controls (Group C). All tubes were implanted into the subcutaneous tissue of the 21 rats. Specimens from each cement type were obtained at 7, 30, and 90 days. Quantitative assessments of inflammatory cells were performed in 5 different areas of each specimen. Results: All animals survive during the follow-up periods except two rats. The mean values of inflammatory cells at 90 days were 14 (±1.8), 15.1 (±3.5), 96 (±12.1), 16 (±2.1) in Groups C, H, P, and Z, respectively. The thicknesses of the fibrous capsule decreased significantly with time in all groups except Group P. Conclusion: Biocompatibility of self-adhesive resin cements was materialdependent. High Q Bond and Zirconite exhibited satisfactory biocompatibility; however, Panavia demonstrated a moderate inflammatory response at 90 days.