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Öğe Effect of septoplasty on the mean platelet volume and inflammation markers(2018) Ulusoy, Bülent; Bozdemir, Kazım; Mişe, Halil İbrahim; Kutluhan, Ahmet; Korkmaz, Mehmet HakanObjective: Nasal septal deviation is an obstructive pathology and can be related to inflammation. This study aimed to investigate therelationship between nasal septum deviation leading to obvious nasal obstruction and certain variables including mean platelet volume(MPV), platelet distribution width (PDW), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR). The study will alsoexamine the effect of this operation on this relationship.Materials and Methods: This is a prospective study. The study sample included 29 patient group participants that had septoplastyindications, and 31 control group participants that were healthy volunteers. Control and patient groups were compared with regard to MPV,PDW, NLR, PLR, platelet count and white blood cell (WBC) counts. The significance level was accepted as 0.05 in the relevant statisticalanalyses.Findings: The preoperative MPV and PDW levels were found to be higher in the patient group than the control group. The differencebetween them was statistically significant (p 0.05). In the patient group, the researchers observed a decrease of 0.72 units in the MPV valueand 0.91 units in the PDW value, and an increase of 6.72 units in the platelet count at the end of the month following the operation comparedwith the relevant values in the preoperative period (p 0.05).Result: The MPV and PDW values were high in the patients with nasal septum deviation requiring surgery. Moreover, these high MPVand PDW values were found to normalize after the operation.Öğe The effectiveness of neutrophil-to-lymphocyte ratio for predicting prognosis of idiopathic sudden hearing loss(ROYAL BELGIAN SOC EAR, NOSE, THROAT, HEAD & NECK SURGERY, 2018) Ulusoy, Bülent; Bozdemir, K.; Akyol, Mesut; Mise, H., I; Kutluhan, A.; Korkmaz, M. HakanThe effectiveness of neutrophil-to-lymphocyte ratio for predicting prognosis of idiopathic sudden hearing loss. Objectives: Here we investigate the relationship between idiopathic sudden hearing loss and neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), mean platelet volume (MPV). and platelet distribution width (PDW), and assess the significance of these markers in predicting response to treatment. Materials and methods: 45 patients and 23 healthy volunteers were included in this retrospective study. Patients were between 18 and 65 years old, diagnosed with idiopathic sudden hearing loss, under the same treatment, and were classified as recovered or unrecovered at the end of treatment. NLR, MPV, PDW and PLR values were determined from complete blood count (CBC) examinations and compared across groups. Results: NLR in the unrecovered group was significantly higher than in the recovered group (Z=2.157; p<0.05), and NLR could be used to predict recovery, as determined by Receiver operating characteristic (ROC) analysis (AUC=0.688, p=0.031, AUC 95% confidence interval: 0.532 - 0.844). MPV was significantly higher in the unrecovered group (F=4.814, p<0.05). Conclusion: NLR and MPV markers can predict prognosis for patients with sudden hearing loss.Öğe Effects of Endoscopic Endonasal Sinus Surgery on Nasal flora in Patients with Chronic Rhinosinusitis with Nasal Polyps(2019) Ulusoy, Bülent; Müderris, Tuba; Çallıoğlu, Elif Ersoy; Bozdemir, Kazım; Oğuzhan, Tolga; Kutluhan, Ahmet; Açıkgöz, Ziya CibaliAim: This study aimed to evaluate the alterations in the nasal flora in patients who underwent endoscopic endonasal surgery forchronic rhinosinusitis with nasal polyps (CRSwNP).Material and Methods: This prospective study included 30 patients diagnosed with CRSwNP who were resistant to medicaltreatment and recommended for surgery. The nasal cavity was sampled two times, first preoperatively on the day of operation andpostoperatively in the 4th week. Patients were divided into two groups according to their culture results, including normal florabacteria and potential pathogen production.Results: In the preoperative swab samples, 3 (11.1%) patients had no bacterial growth, 16 (59.3%) patients had a normal flora, andpotential pathogens were detected in 8 (29.6%) patients. However, postoperatively, 3 (11.1%) patients had no bacterial growth, 13(48.1%) patients had a normal flora, and potential pathogens were detected in 11 (40.7%) patients during the postoperative period.No significant difference was found between preoperative and postoperative culture results in terms of the number of patientswith normal flora, potential pathogens, and no bacterial growth (p0.676). The most common microorganism in the normal floragroup preoperative and postoperative period was coagulase-negative Staphylococcus (77.8%, 51.9%, respectively), and the mostcommon microorganism in the potential pathogen group was Staphylococcus aureus (18.5% and 25.9%, respectively). Comparingpreoperative and postoperative culture results according to isolated potential pathogen microorganism types, no statisticallysignificant difference was observed for any microorganism in the potential pathogen group (p0.05).Conclusion: As a result, no correlation between nasal polyps’ surgery and potential pathogens was detected.Öğe The Evaluation of the Relation Between Nasal Polyp Etiopathogenesis and the Amount of Biofilm(Selçuk Üniversitesi, 2022) Bozdemir, Kazım; Çallıoğlu, Elif Ersoy; Ulusoy, Bülent; Candan, Selami; Koçakoğlu, Nurcan Özyurt; İslamoğlu, Yüce; Serifler, SerkanObjective: To evaluate the effect of biofilm layer on polyp formation in nasal polyposis by comparing the amount of biofilm layer on polyp tissue and the normal mucosa. Materials and Methods: This study is a prospective study. 14 patients who underwent functional endoscopic sinus surgery (FESS) for nasal polyposis were evaluated. Patients were had no history of previous FESS. Tissue samples were obtained from lower turbinate (Group 1 n:14) and from nasal polyp (Group 2, n:14) of the same nasal cavity. Biofilm presence was identified using scanning electron microscopic (SEM) morphological findings. In biofilm positive samples, the presence of biofilm in less than 25% of the surface area was classified as (+), between 25-50% as (++) , and over 50% as (+++). Results: In Group 2, with SEM imaging, (+++) biofilm presence was detected in 9 patients and (++) biofilm was detected in 5 patients. In Group 1, no biofilm was detected 8 patients, while; (+++), (++), and (+) biofilm presence was detected in 1, 2, and 3 patients respectively. Significant difference was found between group 1 and group 2 with respect to the amount of biofilm according to SEM (p =0.000). Conclusion: In samples, statistically significant difference was found between polyp tissue and normal mucosa in terms of the amount of biofilm. However, further studies with larger patient series are required in order to reach a definitive conclusion on the effect of biofilm on pathogenesis of polyp.Öğe Insufficiency of positive airway pressure treatment on increased mean platelet volume: a prospective controlled study in patients with obstructive sleep apnea syndrome(Springer Verlag, 2019) Ulusoy, Bülent; Oğuzhan, Tolga; Akyol, Mesut; Bozdemir, Kazım; Çiftçi, Bülent; Korkmaz, Mehmet HakanBackground: To analyze the association between obstructive sleep apnea syndrome (OSAS) and some hematological variables such as mean platelet volume (MPV), platelet distribution width (PDW), and the impact of positive airway pressure (PAP) treatment on these parameters. Methods: The participants of the present prospective study consist of 36 OSAS patients diagnosed with polysomnography and recommended PAP treatment and 30 healthy members as the control group. Complete blood analyses were conducted to the patient group twice; before the initiation of the PAP treatment and 1 month after regular PAP use. The control group was administered a complete blood analyses only once. Patient and control group were compared in terms of various parameters such as MPV, PDW, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), white blood cell (WBC) values, and platelet counts. Results: MPV value of the patient group was before and after PAP treatment significantly higher than the control group (respectively; Z = 2.246; p = 0.025, and Z = 2.033; p = 0.042). However, there were no statistically significant differences in the values before and after PAP treatment in the patient group (Z = 0.727; p = 0.467). In terms of platelet numbers and PDW values, no significant differences were determined (p > 0.05). Conclusion: MPV value was significantly elevated in OSAS patients. However, the 1 month of PAP treatment was insufficient in decreasing elevated MPV values. © 2019, Springer Nature Switzerland AG.Öğe Lack of association between the glutathione-s-transferase genes (GSTT1 and GSTM1) and nasal polyposis(INT RHINOLOGIC SOC, 2006) Arbağ, Hamdi; Çora, Tülin; Acar, Hasan; Öztürk, Kayhan; Sarı, Fatih; Ulusoy, BülentObjectives: To evaluate the glutation-S-transferase (GST) polymorphisms (GSTM1 and GSTT1) in nasal polyposis (NP). Methods: The study population consisted of 102 unrelated healthy individuals and 98 patients with NP (67 without asthma, 31 with asthma). Genotyping of the polymorphism in the GSTM1 and GSTT1 genes was performed using the multiplex polymerase chain reaction (PCR)-based method. Results: GSTM1 and GSTT1 null-genotypes were found in 46.1% and 23.5% of the controls, and in 43.9% and 33.7% of the NP patients, respectively. These differences were not significant (for GSTM1 null odds ratio (OR) = 0.92; 95% confidence interval (CI) = 0.52-1.6 and for GSTT1, OR = 1.65; 9.5% CI = 0.89-3.07). Although no significant difference for combined GSTM1 and GSTT1 null genotypes between control (8.8%) and NP patients (17.30%) was found, there was a 2.16-fold increased proportion in the NP with the combined GSTM1-null and GSTT1-null genotype (OR = 2.16; 95% CI = 0.91-5.13). Conclusion: These results suggest that there is lack of association between GSTM1 and GSTT1 polymorphisms and NP. The GSTM1 or GSTT1 polymorphisms had also no relevant developing effect on NP patients without or with asthma.Öğe The relation between idiopathic subjective tinnitus and risk factors for venous and arterial thrombosis(2019) Ulusoy, BülentAim: The aim of this study was to investigate the relationship between tinnitus and the factors that cause the tendency to thrombosisin terms of gender.Material and Methods: Fifty-five consecutive patients who admitted to our clinic with the complaint of idiopathic subjective tinnituswere included in this study. Routine ENT (ear nose throat) examinations and pure tone audiometry test were performed. Prothrombintime (PT), partial thromboplastin time (PTT), total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein(HDL) cholesterol, Triglycerides, antithrombin III (AT III), protein C, protein S, homocysteine, antiphospholipid and anticardiolipinantibodies were examined in blood samples of patients. Temporal bone magnetic resonance imaging (MRI) was performed allpatients. The results of the patients were compared in terms of gender and age groups (40 and 40 age).Results: The study was completed with 47 patients. Twenty-four of the patients were female and 23 were male. Both genders groupswere similar in terms of age and pure tone average. Antiphospholipid and anticardiyolipin antibodies (IgG and IgM) were found asnegative in all patients. Homocysteine levels were found to be statistically significantly higher in males than females (p0.015;respectively 13.385.98 ?mol/L and 9.873.11 ?mol/L). AT III and Protein S levels were lower in males than females although thisdifference was not statistically significant (respectively p0.07 and p0.08)Conclusion: In this study, an association was shown between hyperhomocysteinemia and tinnitus, especially in males.
