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    The Disposition and Milk Levels of Sulfamethoxazole - Trimethoprim Combination After Intrauterine Administration in Lactating Cows During Post-Partum
    (Indian Veterinary Journal, 2000) Elmas, Muammer; Tras, Bunyamin; Bas, Ahmet levent; Yazar, Enver; Umitli, Seyit; Birdane, Yavuz Osman
    The sulphonamide-trimethoprim combinations are commonly used yia intrauterine administration in the therapy of genital diseases of large animals in Turkey (Elmas et a/., 1999; Kaya, 1998). Several workers have studied the absorption and elimination of various sulphonamidetrimethoprim combinations in different species (Chaudray et al., 1987; Boyd and Allen,,1989;Eimas etal., loc.cit }, However, no pharmacokinetic studies have been carried. out on the use of sulfamethoxazole (SMZ) - trimethoprim (TMP) in lactating cows during post-partum. We investigated the disposition of SMZ-TMP combination along with passing ratio to milk following intrauterine bolus administration in cows during, post-partum.