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    Pharmacokinetics of danofloxacin in rainbow trout after different routes of administration
    (Elsevier B.V., 2020) Terzi E.; Corum O.; Bilen S.; Kenanoglu O.N.; Atik O.; Uney K.
    The pharmacokinetics of danofloxacin was studied in rainbow trout (Oncorhynchus mykiss) after single administration by intravenous (IV), intramuscular (IM) and oral (OR) gavage at a dose of 10 mg/kg and by 10 mg/L bath for 2 h at 11.7 ± 0.8 °C. Furthermore, minimal inhibitory concentrations (MICs) of danofloxacin against a pathogenic strain of Yersinia ruckeri, Pseudomonas spp., and Aeromonas hydrophila were determined. Plasma concentrations of danofloxacin were determined using high-performance liquid chromatograph - UV and further subjected to noncompartmental analysis. Elimination half-lives for IV, IM, OR and bath administration were 25.97 h, 42.43 h, 41.04 h and 40.41 h, respectively. Peak plasma concentrations (Cmax) for IM, OR and bath administration were 3.64 ± 0.12, 2.93 ± 0.23, and 0.36 ± 0.02 ?g/mL, respectively. Bioavailability was 105.87% (IM), 96.92% (OR) and 10.09% (bath). MIC values were 0.02 ?g/mL for Y. ruckeri, 3.2 ?g/mL for Pseudomonas spp., and 8 ?g/mL for A. hydrophila at 12 °C. Danofloxacin provides the desired AUC0 – 24/MIC (?125) and Cmax/MIC (?10) values for Y. ruckeri following administration at a dose of 10 mg/kg (L) from all routes administration, whereas inadequate for Pseudomonas spp. and A. hydrophila. This information may help in the use of danofloxacin in rainbow trout, but increasing doses pharmacokinetics with the residue depletion study and clinical studies in infected fish are needed. © 2020 Elsevier B.V.
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    Tildipirosin may cause cardiotoxicity in sheep
    (Scientific Publishers of India, 2017) Dik B.; Bahcivan E.; Faki H.E.; Uney K.
    Tildipirosin is a 16-membered ring, tribasic and semi-synthetic macrolide antibiotic. The aim of this study was to determine the safety of tildipirosin following a single treatment at doses of 4 mg/kg and 8 mg/kg via subcutaneous injection. In the current research, tildipirosin (SC, single treatment) was applied at the doses of 4 and 8 mg/kg to the Normal Dose (ND) and High Dose (HD) group, respectively. Blood samples were gained before (0th d) and after treatments on 0.25, 0.5, 1, 3 and 21 d’s. Hemogram, biochemical and oxidative stress parameters were determined from blood samples. High dose tildipirosin increased cardiac damage parameters including creatine kinase-MB mass and partially troponin I within the first day, and high dose tildipirosin decreased statistically significant the thiobarbituric acid reactive substances levels on 1 and 3 d compared with ND group. Statistically significance fluctuations within reference ranges were observed in the biochemical and hemogram values. In conclusion, high dose tildipirosin may cause cardiotoxicity in sheep. However, cardiography, monitorization and histopathological evaluations should be done to determination of adverse effects of different doses of tildipirosin in sheep. © 2017, Scientific Publishers of India. All rights reserved.