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    Cavitary pulmonary lesion due to systemic lupus erythematosus: An unusual manifestation
    (PROFESSIONAL MEDICAL PUBLICATIONS, 2011) Maden, Emin; Teke, Turgut; Uzun, Kursat
    Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown pathogenesis. In this abstract we report a 34 years old female SLE case with cavitary pulmonary lesion as the pulmonary manifestation. In literature, SLE with cavitary pulmonary lesion is reported very rarely and thought to be due to infection or pulmonary embolism. Our case had no signs of infection and no finding of pulmonary embolism, the lesion resolved by steroid therapy and without antibiotic administration. In conclusion SLE should be thought in differential diagnosis of cavitary pulmonary lesions.
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    Detection and quantification of the parenchymal abnormalities in emphysema using pulmo-CT
    (PERGAMON-ELSEVIER SCIENCE LTD, 2007) Temizoz, Osman; Etlik, Omer; Sakarya, Mehmet Emin; Uzun, Kursat; Arslan, Halil; Harman, Mustafa; Demir, Mustafa Kemal
    We aimed to determine the degree and extent of parenchymal abnormalities on pulmo-CT in patients with emphysema. The study group consisted of 29 patients (18 male, I I female; mean age 57.9. L 13). The diagnosis was based on clinical symptoms, pulmonary function tests (PFT) values, and chest CT findings. All of the patients CT scans were obtained during suspended deep inspiration from the apices to the costophrenic angles. The mean lung attenuation (MLD) and parenchymal abnormalities related to emphysema were quantitatively calculated with tables, histograms and graphics at the whole lung. The lung density measurements revealed a mean density of -898.48 +/- 51.37 HU in patients with emphysema and -825.1 +/- 25.5 HU in control group. In addition, mean percentage of subthreshold attenuation values was found as 12.03 +/- 15.75 and 1.07 +/- 0.83 in patients with emphysema and control group, respectively. Compared with control group, the patients with emphysema had a significantly lower inspiratory MLD (p < 0.05). Additionally, statistically significant correlations were seen between the MLD and percentage of subthreshold values (r = 0.44, p < 0.05). In contrast, there was poor correlation between PFT measurements and the subthreshold values. In conclusion, pulmo-CT is a quick, simple method for quantitative confirmation of the presence of parenchymal abnormalities of lung as mosaic attenuation and should be used in combination with other radiological methods and PFT as it gives additional information to routine examinations in patients with emphysema. (c) 2007 Elsevier Ltd. All rights reserved.
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    The effect of theophylline on oxidative stress in serum and tissues in mechanical ventilation-induced diaphragm dysfunction
    (TURKISH BIOCHEM SOC, 2011) Uzun, Kursat; Aydin, Nihal Bakirkalay; Teke, Turgut; Buyukbas, Sadik; Basarali, Kemal
    Introduction: The role of oxidative stress in mechanical ventilation induced diaphragm dysfunction (VIDD) was shown in various studies. In this animal model, we planned to evaluate the role of diaphragmatic and systemic stress on VIDD and the effect of theophylline application on the oxidative stress. Material and methods: Thirty healthy male Sprague-Dawley rats were used. They were evenly divided into 3 groups as Group 1, control group (no application); group 2, placebo group receiving mechanical ventilation (MV); Group 3, theophylline group receiving both MV and theophylline. Malondialdehyde (MDA) and nitric oxide (NO) levels with xanthine oxidase (XO) and superoxide dismutase (SOD) activities were measured in all groups to evaluate the oxidative stress at diaphragm, lung tissue and plasma. Results: SOD (0.01-0.07 U/mg) and XO (0.61-1.76 U/g) activities with NO (0.05-0.14 mu mol/g) levels at diaphragm; XO (0.36-2.26 U/g) activity at lungs and SOD (2.06-5.24 U/mL) and XO (7.76-14.04 U/mL) activities with MDA (0.35-1.09 nmol/L) levels at plasma were significantly increased in placebo group (p < 0.05) compared to control. Upon theophylline therapy, SOD (0.096 U/mg) activity at diaphragm and plasma NO (22.3-29.7 mu mol/L) levels were significantly increased (p < 0.05); whereas XO (0.39 U/g) activity at lungs and plasma MDA (0.36 nmol/L) levels were significantly decreased (p < 0.001) compared to placebo group. Conclusion: In this study, we showed that pulmonary and systemic oxidative stresses accompany MV application induced diaphragmatic oxidative stress in rats and this oxidative stress is predominantly occurs through XO pathway. Also it was demonstrated that theophylline alleviates this oxidative stress by increasing the SOD activity and repressing the XO activity. However, more animal and human studies at molecular level are needed on this subject. Conflict of Interest: Authors have no conflict of interest.