Yazar "Vatansev, Husamettin" seçeneğine göre listele
Listeleniyor 1 - 15 / 15
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis(WALTER DE GRUYTER GMBH, 2013) Vatansev, Husamettin; Ozturk, Bahadir; Yilmaz, Sema; Sivrikaya, Abdullah; Dagli, Mehmet; Kiyici, Aysel; Unlu, AliObjective: Rheumatoid arthritis (RA) is a chronic inflammatory disease and it is associated with premature atherosclerosis development. RA patients have multiple factors to develop premature atherosclerosis. Enhanced asymmetric dimethylarginine (ADMA) is considered as a risk factor for the development of atherosclerosis by inducing endothelial dysfunction. The aim of this study was to investigate the role of asymmetric dimethylarginine, arginine and citrulline levels in patients with RA and their relation to the disease activity parameters for possible role on the disease activity. Methods: 92 patients with RA and 34 healthy controls were included the study. Patients and control blood samples collected for ADMA, arginine and citrulline levels. ADMA, arginine and citrulline levels were measured by pre-column derivatization fluorescence HPLC method. CRP and ESR levels examined on the same day were taken from the patient records. Results: While ADMA levels significantly increased, arginine levels decreased in the patient group. There was no difference in citrulline levels between both groups. Only citrulline and arginine showed a weak positive correlation. ADMA, arginine, and citrulline levels showed no correlation with either biochemical parameters such as CRP or ESR, or disease activity or disease severity. Conclusion: Our study has shown that an increase in ADMA levels with the decrease in arginine levels suggests an increase in arginine turnover to ADMA. Increased ADMA levels can be used for an increased risk for premature development of atherosclerosis in patients with RA. Since high ADMA levels prevent the NO-dependent vasodilatation, a possible role of ADMA in development of premature atherosclerosis may be independent from inflammation.Öğe Asymmetric dimethylarginine levels in Behcet's disease(WALTER DE GRUYTER GMBH, 2014) Ozturk, Bahadir; Vatansev, Husamettin; Taner, Alpaslan; Yilmaz, Sema; Dagli, Mehmet; Unlu, AliObjective: Behcet's disease (BD) is a chronic, inflammatory, multisystem vasculitis and the etiology is not yet fully understood. Nitric Oxide (NO) is an important molecule for the vascular system which synthesised by the Nitric Oxide Synthase (NOS) enzyme. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NOS. Therefore, we aimed to investigate levels of the ADMA and its relation with exacerbations in BD patients. Methods: The subjects enrolled in this study were recruited from 34 patients with BD and 34 healthy controls. Serum levels of ADMA, arginine and citrulline were measured by HPLC with fluorescence detection. The ESR and CRP levels analyzed by routinely used methods. Results: In contrast to information in the literature, ADMA levels were found to be decreased in BD patients when compared to control. Inversely, Arginine and Citrulline levels were significantly increased in BD patients. Increased Arginine/ADMA ratios were found in the patient group. There was an inverse relation between ADMA and CRP levels. Arginine values were also correlated CRP and Citrulline levels. Conclusion: One of the reasons of high number of BD attacks in young age may be low levels of ADMA. Our study suggests that the reduced levels of ADMA in patients group may impose a possible preventive role to ADMA through decrease of NO-mediated inflammation and exacerbations of BD with aging.Öğe Chemical Composition of Nigella sativa L. Seeds Used as a Medical Aromatic Plant from East Anatolia Region, Turkey(ASIAN JOURNAL OF CHEMISTRY, 2013) Vatansev, Husamettin; Ciftci, Harun; Ozkaya, Ahmet; Ozturk, Bahadir; Evliyaoglu, Nurcan; Kiyici, AyselIn this study, chemical composition such as vitamins, fatty acids and trace elements of Nigella sativa L. seeds collected from East Anatolia Region of Turkey were investigated. Fatty acids in the lipid extracts were converted into methyl esters. The methyl esters were extracted with n-hexane, they were separated and quantified by gas chromatography. Fat soluble vitamins were determined by HPLC and the mixture of acetonitrile/methanol (3/1, v/v) was used as the mobile phase. For determination of trace elements levels, solutions from microwave digestion of a certain amount of seeds were analyzed with inductively coupled plasma optical emission spectrometry. Main fatty acids of Nigella sativa L. seeds were found as 66.5 and 23.5 (as relative % peak area) for linoleic acid (18: 2) and oleic acid (18: 1), respectively. The contents of Co, Ni, Fe, Zn, Cu, Mn and Cr were determined as 0.12, 1.48, 117.32, 41.42, 30.26, 28.56 and 2.55 mu g/g (dry matter) respectively. The levels of vitamins were found as 10.19 mu g/g for alpha-tocopherol, 2.28 mu g/g for delta-tocopherol, 0.18 mu g/g for retinol, 1.38 mu g/g for vitamin D-2 1.85 mu g/g for vitamin K-1 and 2.15 mu g/g for vitamin K-2. The Nigella sativa L. seeds were found to be rich in unsaturated fatty acids, vitamins and trace elements, suggesting that they may be valuable for apoptosis and would be appropriate to further studies in this direction.Öğe DETERMINATION OF SERA NGAL LEVELS IN PATIENTS WITH LUNG CANCER AND ITS RELATION WITH APOPTOSIS(PARLAR SCIENTIFIC PUBLICATIONS (P S P), 2018) Ozturk, Bahadir; Ciftci, Harun; Vatansev, Husamettin; Gun, Fatma Gul; Sunam, Guven Sami; Oncel, Murat; Karabagli, PinarThe NGAL synthesis induces in neoplasms; therefore, probably, it is benefited from the level of this protein for the determination of carcinogenesis and the progress stages of human tumors. In this study, it was aimed to investigate the expression of NGAL (neutrophil gelatinase associated lipocalin) in lung cancer patients and its relation with apoptosis. The study was conducted on the patients between the ages of 40 and 70 years accepted by the Thoracic Surgery Clinic (Selcuk University, Faculty of Medicine) based on their lung cancer diagnosis. The patients aged between 40 and 70 were included in the study from the thoracic surgery clinic of the Selcuk University as they were administered into the clinic based on their lung cancer diagnosis and had operation before. Patients who have acute stroke, rheumatic diseases, chronic kidney disease, congestive heart failure, chronic infection and other organ and system cancers (except lung cancer) were excluded from the study. Two groups including a lung cancer group (N=40) and a normal group (N=40) were formed to determine the NGAL and M30 levels in sera of patients using the ELISA method. According to the analysis results, the NGAL levels for the lung cancer group and the normal group were observed as 424.03 +/- 74.49 and 374.04 +/- 90.34 ng/mL, respectively. This increase in the lung cancer group was found statistically significant according to the normal group (p < 0.01). The M30 levels, marker for apoptosis in circulation, were obtained as 144.08 +/- 45.91 and 118.76 +/- 46.16 U/L for the lung cancer group and the normal group, respectively. This increase in the lung cancer group was found statistically significant according to the normal group (p < 0.01). A positive correlation was obtained between the NGAL and M30 data by means of Spearman's correlation test (r(40)=0.58, p < 0.01). The antigen levels of caspase 3, 8 and 9 were determined by the immunohistochemical staining methods in the samples of cancerous tissues and normal tissues adjacent to the cancerous tissue, and the apoptotic indexes were calculated. The apoptotic indexes of the cancerous tissues were significantly lower than the normal tissues (p < 0.01). This result demonstrates that the predominant type of cell death might be other cell death pathways rather than the apoptotic pathways in lung cancer. In addition, these results support the opinion about the fact that apoptosis may be inhibited by cancer cells in cancerous tissues. The significant increase in the M30 and NGAL levels supports the claims of the previous studies about the fact that it causes the consumption of cellular iron reserves and NGAL induced apoptosis in cancer patients.Öğe The Effect of Exercise, Reflexology and Chrome on Metabolic Syndrome(SUAMTHI PUBLICATIONS, 2018) Arslan, Fatma; Guven, Sefika Dilek; Ozcan, Aysegul; Vatansev, Husamettin; Tasgin, OzdenBackground: Metabolic syndrome (METS) is associated with a cardiovascular risk factor characterized by waist circumference, hypertension, hypertriglyceridemia, low HDL, and high blood sugar. Exercise and physical activity might support the prevention of metabolic syndrome. Study design: This study comprised a 12-week randomized controlled trial. Method: A total of 25 university workers with METS risk factors participated in this study voluntarily. They were randomly divided into 3 groups: those undertaking a core exercise program (n=7), reflexology intervention group (n=8) and chrome intake group (n=10). The subjects took part in a core exercise program for 1 hour per day, 3 days a week and a reflexology interfered for 30 minutes per day, 1 day a week and chrome group took chromium picolinate every day in the week for 12 weeks. The components of METS were analyzed before and after the completion of all the intervention. Results: There were significant differences in pre-prandial blood glucose (PBG) in the core exercise group and at systolic blood pressure (SBP) in chrome group after the 12-week interventions (p<0.005). While high-density lipoprotein cholesterol (HDL-C) excluding the components of METS decreased after the interventions on all groups; levels of HDL-C and the other components of METS decreased in reflexology group. Conclusion: There was a clear response to the 12-week interventions regarding METS control. Besides, the reflexology intervention should not be applied to individuals with low HDL-C levels, and core exercise and intake chrome picolinate suggested to improve the components of METS.Öğe Effects of Prednisolone, l-Asparaginase, Gemfibrozil, and Combinations of These Elements on Mice Lipid Profile, Liver, and Pancreas(LIPPINCOTT WILLIAMS & WILKINS, 2016) Kose, Dogan; Tarakci, Nuriye; Celik, Zeliha Esin; Vatansev, Husamettin; Cimbek, Emine Ayca; Ugras, Serdar; Sen, YasarThe aim of this study is to determine the effects of l-asparaginase (l-ASP), corticosteroids (CSs), and antilipidemics, separately and in combination, on the lipid profiles and the liver and pancreas histology in mice. This study included 8 groups of 7 mice each. Before any drug administration, serum samples were taken from all of the mice. Then, normal saline was applied to the control group, and a medication or combination of medications was applied to the other groups. Levels of triglycerides, cholesterol (COL), and high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were determined, and the livers and pancreases were evaluated histologically at the end of the study. Triglycerides increased significantly in the CS-only and the l-ASP-only groups, COL increased significantly in the CS-only group, and HDL increased significantly in the CS-only and the antilipidemic-only groups. LDL was significantly lower in the CS-only and the l-ASP-only groups. CSs and l-ASP were significantly effective in liver necrosis, l-ASP was significantly effective in liver balloon degeneration, and CS were significantly effective in pancreas vacuolization. Triglyceride measurement is recommended before/during CS and/or l-ASP treatment. Starting with an antilipidemic agent can be considered to avoid possible complications in patients with significantly high rates. Indicators of a possible liver or pancreas injury should also be considered.Öğe Enzymatic Debridement in Necrotizing Pancreatitis(INT COLLEGE OF SURGEONS, 2015) Cakir, Murat; Tekin, Ahmet; Kucukkartallar, Tevfik; Vatansev, Husamettin; Kartal, AdilMultiple organ failure and pancreatic necrosis are the factors that determine prognosis in acute pancreatitis attacks. We investigated the effects of collagenase on the debridement of experimental pancreatic necrosis. The study covered 4 groups; each group had 10 rats. Group I was the necrotizing pancreatitis group. Group II was the collagenase group with pancreatic loge by isotonic irrigation following necrotizing pancreatitis. Group III was the collagenase group with pancreatic loge following necrotizing pancreatitis. Group IV was the intraperitoneal collagenase group following necrotizing pancreatitis. The progress of the groups was compared hematologically and histopathologically. There was no difference among the groups regarding the levels of leukocyte, hemogram, and urea. The differences in AST levels between Group I and II; and differences in glucose, calcium, LDH, AST, and amylase between Group II and III; between Group II and IV; between Group I and III; and between Group I and IV were statistically significant (P < 0.05). There were statistically significant differences between Group II and III, and Group II and IV regarding edema, acinar necrosis, inflammatory cell infiltration, hemorrhage, and fat necrosis (P < 0.05). In conclusion, the collagenase preparation used in this experimental pancreatitis model was found to be effective in the debridement of pancreatic necrosis.Öğe Growth-differentiation factor-15 and tissue doppler imaging in detection of asymptomatic anthracycline cardiomyopathy in childhood cancer survivors(PERGAMON-ELSEVIER SCIENCE LTD, 2013) Arslan, Derya; Cihan, Tugba; Kose, Dogan; Vatansev, Husamettin; Cimen, Derya; Koksal, Yavuz; Oran, BulentObjectives: Anthracyclines have led to an increased risk of cardiac morbidity and mortality. Late cardiac complications in cancer survivors may develop from subclinical myocardial damage. Tissue Doppler imaging (TDI) also has potential as a clinically useful technique for the assessment of myocardial function. Biochemical markers may be used to detect cardiac damage growth-differentiation factor-15 (GDF-15) and are emerging as a biomarker of cardiac dysfunction. The aim of this study is to assess the value of the plasma levels of GDF-15 and TDI in detecting late myocardial dysfunction in childhood cancer survivors (CCS) who were treated with anthracyclines. Design and methods: Thirty-eight CCS who had completed chemotherapy treatment with anthracyclines were included in this study. Control group consisted of 32 age- and gender-matched healthy volunteers. All children underwent a detailed echocardiography, which contained an M-mode, pulse Doppler and tissue Doppler imaging. However, GDF-15 and cardiac troponin-I (cTnI) were measured. Results: Although, systolic function of the left ventricular was similar in all groups, there were significant differences between parameters of diastolic function of the heart. The mitral valve E wave, E/A ratio, left ventricular E'm wave, and E'm/A'm ratio were different in the patients than in the controls (p = 0.049, p = 0.037, p < 0.0001, p = 0.001, respectively). The tricuspid valve E/A ratio, right ventricular E't wave, and E't/A't ratio in the patients were also different from those of the controls (p = 0.031, p < 0.0001, p < 0.0001, respectively). Mean plasma GDF-15 was significantly higher in patients than healthy controls (p = 0.027). There were no significant differences in cTnI between both groups. Conclusions: Growth-differentiation factor-15 level may be used as a biomarker of anthracycline-induced cardiovascular disease severity in the CCS. (c) 2013 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.Öğe The in vivo investigation of apoptotic effects of Nigella sativa on carbon tetrachloride-induced hepatotoxicity(NATL INST SCIENCE COMMUNICATION-NISCAIR, 2018) Uysal, Tuna; Ugurtan, Mevlut Han; Sezer, Ela Nur Simsek; Vatansev, Husamettin; Bozkurt, Meryem; Evliyaoglu, NurcanNigella sativa commonly known as black seed or black cumin has been used for medicinal purposes for centuries. Our purpose in this study is to determine the apoptotic effects of black cumin seed oil (N. sativa) on CCl4 induced hepatoxicity via molecular markers. For this aim, four experimental groups were created and each of them was intraperitoneally exposed to CCl4 (G2), CCl4 + black cumin oil (G3) and black cumin oil (G4) except from control (G1). DNA fragmentation, RT-PCR, and caspase-3 assay were carried out. According to our results, a remarkable morphological anointment was observed at the G2. The G3 had the lower fatty comparing to G2. DNA profiles were visualized and DNA fragmentation was only in the G3. PCR results showed that BAX gene expression fairly rose in the G3 and BCL-2 gene expression was only determined in the G2. Decreased caspase-3 in G2, and the increased of it's in G3, clearly supported the activation of the apoptotic pathway for injured cells. Consequently, our results indicated that the increases of caspase and BAX/BCL-2 rates demonstrated that there was an effective molecular mechanism based on black cumin induced apoptosis in rat liver which leads to the release of cytochrome-c from the mitochondria to the cytosol, finally activating caspase-3 and resultant apoptosis.Öğe N-terminal-pro brain natriuretic peptide levels in children with allergic rhinitis(TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2016) Artac, Hasibe; Vatansev, Husamettin; Cimen, Derya; Arslan, Derya; Kaya, Fatma; Kayis, Seyit Ali; Oran, BulentBackground/aim: Persistent upper airway obstruction may lead to increased pulmonary arterial pressure (PAP). The aim of this study was to evaluate N-terminal pro brain natriuretic peptide (NT-proBNP) concentrations and PAP values in children with allergic rhinitis. Materials and methods: Sixty-six patients with allergic rhinitis and 22 healthy children were prospectively enrolled in this study. Plasma NT-proBNP levels were measured at first admission and after treatment. Simultaneously, echocardiography was done to assess pulmonary arterial hypertension, and rhinitis symptom scores were recorded. Results: The median age of the study group was 9.0 (5.0. 17.0) years; 26 were female. PAP was found to be normal in all the patients. There was a negative correlation between age and NT-proBNP levels (r = -0.452, P < 0.01). Nasal blockage levels affected NT-proBNP levels mildly (P = 0.067). No significant difference between before and after nasal steroid treatment was observed in NT-proBNP levels. Conclusion: These results suggest that NT-proBNP level and PAP may not be affected in children with allergic rhinitis, and primarily this influence may be associated with the severity of nasal obstruction.Öğe P-wave duration and dispersion in children with uncomplicated familial Mediterranean fever(TAYLOR & FRANCIS LTD, 2013) Arslan, Derya; Oran, Bulent; Yazilitas, Fatma; Peru, Harun; Cimen, Derya; Vatansev, HusamettinObjectives This was a prospective controlled study to determine the P-wave duration (Pdu) and P-wave dispersion (Pd) in patients with familial Mediterranean fever (FMF). Methods The study group consisted of 26 children with uncomplicated FMF and 25 age-and sex-matched healthy controls. We performed electrocardiography (ECG) with Doppler echocardiography on patients and controls. All participants underwent 12-lead electrocardiography under strict standards. Pdu and Pd were computed from a randomly selected beat and from an averaged beat constructed from 12 beats, included in a 10-s ECG. Results The left ventricle (LV) dimensions, LV ejection fraction (LVEF), and LV fractional shortening (LVFS) values, left atrium dimension, and aortic dimension were in normal range in both groups. There were significant differences between the groups regarding LV-isovolumic relaxation time (IRT), LV-isovolumic contraction time (ICT), right ventricle (RV)-ICT, RV-IRT, and Pd (all p < 0.0001). However, highly significant positive correlation was detected between LV-ICT, LV-IRT, RV-ICT, RV-IVT, C-reactive protein (CRP), and Pd (r = 0.505, p < 0.0001; r = 0.483, p < 0.0001; r = 0.433, p = 0.001; r = 0.421, p = 0.001; r = 0.452, p = 0.001; r = 0.478, p < 0.0001, respectively). Conclusions Uncomplicated FMF children who are continuously treated with colchicine and do not develop amyloidosis have abnormal atrial dispersion and therefore seemingly have an increased electrocardiographic risk of atrial fibrillation.Öğe Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice(AVES, 2017) Savdan, Mervan; Cakir, Murat; Vatansev, Husamettin; Kucukkartallar, Tevfik; Tekin, Ahmet; Tavli, SakirObjective: Tissue damage and endotoxemia in obstructive jaundice are attributed to the increase in oxygen free-radicals. We aimed at evaluating the possible protective effect of grape seed proanthocyanidin extract (GSPE), which is a potent exogenous free-radical scavenger and antioxidant. Material and Methods: The study was performed at the Necmettin Erbakan University Meram School of Medicine Research and Application Center for Experimental Medicine Laboratory with ethical approval. 30 Wistar-Albino rats were used and were divided into 3 groups. The common bile duct was identified and only dissected in the first group (sham). Following dissection of the common bile duct it was ligated with 4/0 silk just above the pancreas in the second group (control). After ligation of the common bile duct, 100mg/kg/day GSPE was administered via orogastric lavage for 10 days in the third group. Results: Biochemical values revealed a statistically significant difference between Group I and the others. There was no difference between Group II and III regarding biochemical values. There was a statistically significant difference, however, between Group II and III with regards to nitric oxide levels. There was a statistically significant difference between Group I and the other groups concerning hepatic and pulmonary tissue damage on histopathologic evaluation. There was no difference among the groups with regards to renal tubular damage. Conclusion: Proanthocyanidin is an effective natural antioxidant in decreasing the level of tissue damage caused by oxygen free-radicals.Öğe Release of NT-pro brain natriuretic peptide in children before and after adenotonsillectomy(ELSEVIER IRELAND LTD, 2013) Oran, Bulent; Ozturk, Kayhan; Cimen, Derya; Vatansev, Husamettin; Bulut, Serap; Arslan, DeryaObjectives: To measure serum B-type natriuretic peptide, especially N-terminal segment of its prohormone (NT-proBNP) and pulmonary arterial pressure levels and to determine whether NT-proBNP concentrations correlate with pulmonary arterial pressure levels in children before and after adenotonsillectomy. Methods: Twenty children with adenoid and tonsil hypertrophy and 20 healthy subjects were included in the study. Transthoracic echocardiography was performed in all patients to assess pulmonary artery systolic and diastolic pressure with cardiac dysfunction. The NT-proBNP was analyzed for correlation with pulmonary artery pressure. Results: Our results showed that prohormone serum concentrations and pulmonary arterial pressures were significantly higher in the study group than in the control group at the preoperative evaluation. A significant decrease was detected among patients after surgery (p < 0.05). There was no significant difference between the study and control groups for prohormone serum concentration and pulmonary arterial pressure at the postoperative evaluation (p > 0.05). Conclusion: We found increased serum prohormone levels and height pulmonary artery pressures in the children with adenoid and tonsil hypertrophy when comparing with healthy subjects. Our study supported that increased serum prohormone levels and pulmonary artery pressures as a result of adenoid and tonsil hypertrophy are reversible. Pediatric cardiologs and otolaryngologs should keep in mind an increased pulmonary artery pressure during management of children with adenoid and tonsil hypertrophy. Furthermore, Doppler echocardiography may be useful in the monitoring of pulmonary arterial pressure and in the follow-up of surgical outcome of children with adenoid and tonsil hypertrophy. (C) 2013 Elsevier Ireland Ltd. All rights reserved.Öğe Serum Asymmetric Dimethylarginine Levels in Patients with Acute Rheumatic Fever(GEORG THIEME VERLAG KG, 2015) Sert, Ahmet; Cimen, Derya; Arslan, Derya; Aypar, Ebru; Vatansev, Husamettin; Kaya, Fatma; Kilicaslan, CengizhanAsymmetric dimethylarginine (ADMA) is an analogue of L-arginine, a naturally occurring product of metabolism found in human circulation. It is an endogenous inhibitor of nitric oxide production. Acute rheumatic fever (ARF) is a delayed immunologically mediated autoimmune sequel of throat infection by group A beta-hemolytic streptococci. As serum ADMA levels have not previously been assessed in patients with ARF, we aimed to investigate ADMA levels in patients with ARF during the acute stage and after anti-inflammatory treatment and compared results with healthy control subjects. The study population consisted of 34 children with ARF (30 patients with carditis and 4 patients without carditis) and 31 healthy control subjects. Erythrocyte sedimentation rate and C-reactive protein values were significantly higher and serum ADMA values were lower, but not statistically significant in patients with ARF during the acute stage when compared with controls. Serum C-reactive protein and erythrocyte sedimentation rate values were significantly decreased in patients with ARF after the treatment when compared with baseline and ADMA levels were increased after the treatment compared with baseline, but this change was not statistically significant. Our study has demonstrated that resolution of acute inflammation in patients with ARF may lead to a mild increase in serum concentration of ADMA. Comprehensive prospective and observational studies are required to confirm our findings and to assess potential interactions between ARF and ADMA levels.Öğe The usefulness of plasma asymmetric dimethylarginine (ADMA) levels and tissue doppler echocardiography for heart function in term infants born to mothers with gestational diabetes mellitus(TAYLOR & FRANCIS LTD, 2013) Arslan, Derya; Oran, Bulent; Vatansev, Husamettin; Cimen, Derya; Guvenc, OsmanObjective: The aim of this study was to examine whether asymmetric dimethylarginine (ADMA) concentrations are associated with ventricular function in the infants of mothers with gestational diabetes. Method: Twenty-five term newborns of mothers with gestational diabetes and term newborns as the control group (n=25) with normal general health status were evaluated at two time points, on the 3rd postnatal day, at the 3th months. Echocardiographic evaluations of all participants were performed and ADMA level was measured. Results: In the first analysis, 10 patients (40%) had a septal thickness of 6mm or more, indicating septal hypertrophy. In the first and second analysis, interventricular septum end-diastolic thickness (IVSTd) and the left ventricular posterior wall end-diastolic thickness (LVPWTd) in the patient group were higher than the control group. ADMA level measurement was not significantly different between the groups the first and second analysis. There was no difference in ADMA levels of the group with septal thickness >= 6mm and the group with <6 mm. Conclusion: Newborn cardiac wall thickness was increased in pregnancies complicated by Gestational diabetes mellitus (GDM), and the increase was independent of glycemic control. Diastolic newborn cardiac function was impaired in GDM, and this effect was independent of septal thickness. We found no association between ADMA levels and cardiac systolic, diastolic functions or septum thickness in the GDM newborn.
