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  • Küçük Resim Yok
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    Incidence of Cyclophosphamide-induced Urotoxicity and Protective Effect of Mesna in Rheumatic Diseasesle
    (J RHEUMATOL PUBL CO, 2015) Yilmaz, Neslihan; Emmungil, Hakan; Gucenmez, Sercan; Ozen, Gulsen; Yildiz, Fatih; Balkarli, Ayse; Kimyon, Gezmis
    Objective. To assess bladder toxicity of cyclophosphamide (CYC) and uroprotective effect of mesna in rheumatic diseases. Methods. Data of 1018 patients (725 women/293 men) treated with CYC were evaluated in this retrospective study. All of the following information was obtained: the cumulative CYC dose, route of CYC administration, duration of therapy, concomitant mesna usage, and hemorrhagic cystitis. Cox proportional hazard model was used for statistics. Results. We identified 17 patients (1.67%) with hemorrhagic cystitis and 2 patients (0.19%) with bladder cancer in 4224 patient-years. The median time for diagnosis to hemorrhagic cystitis was 10 months (4-48) and bladder cancer was 8 years (6-10.9). There were 583 patients (57.2%) who received mesna with intravenous CYC therapy. We observed similar incidence rate for hemorrhagic cystitis in both patient groups concomitantly treated with or without mesna [9/583 (1.5%) vs 8/425 (1.8%) respectively, p = 0.08]. Cumulative CYC dose (HR for 10-g increments 1.24, p < 0.001) was associated with hemorrhagic cystitis. Conclusion. Cumulative dose was the only risk factor for hemorrhagic cystitis in patients treated with CYC. No proof was obtained for the uroprotective effect of mesna in our cohort.
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    Investigation of the dynamic behavior of soils of Konya Organized Industrial Zone by equivalent linear analysis method
    (Selçuk Üniversitesi, 2021) Demiroz, Atila; Yildiz, Fatih
    In seismically active regions, earthquakes occur with sudden vibration waves as a result of fractures in the earth’s crust since the formation of the Earth. It is not possible to prevent earthquakes, which cause loss of life and property, as in other natural disasters. However, it is possible to minimize the damage caused by earthquakes. Predicting and determining the behavior of soils under the influence of earthquakes is of great importance in the design of structures. Our country is also characterized as an active country in terms of earthquakes. As it is known, soils can reduce their effect by dampening seismic waves at certain frequencies acting on them, while some frequencies can have amplifying effects. Therefore, the dynamic behavior of soils must be determined through analysis. In this study, regions in different locations in Konya Organized Industrial Zone were determined and different numbers of boreholes were selected. The data to be used in the analyzes were obtained from the region and representative soil profiles were created. Equivalent linear soil behavior analysis of the obtained soil profiles was carried out using the DEEPSOIL program. Values such as maximum surface accelerations, spectral accelerations, ground amplifications obtained as a result of the analyzes made in this region have been examined in detail in comparison.