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    Investigation of serum nitric oxide, oxidized low density lipoprotein and total antioxidant activity in obese subjects and healthy controls
    (ORTADOGU AD PRES & PUBL CO, 2008) Yerlikaya, Huemeyra F.; Mehmetoglu, Idris; Kurban, Sevil; Yilmaz, Guelsuem
    Objective: Obesity which is defined as a disease characterized by increased lipid tissue and excessive lipid storage in the body, is not only a basic esthetic problem but also a chronic disease which has bad effects on physiological and physiciatric health. The etiopathogenesis of obesity is not exactly known. In this study, we aimed to investigate serum nitric oxide (NO), oxidized low density lipoprotein (Ox-LDL) and total antioxidant activity (TAA) of obese sucjects to determine the role of these parameteres on the etiopathogenesis of the disease. Material and Methods: This study was performed on 33 obese subjects (8 M, 25 F; aged 29-69 years) and 30 healty control (16 M, 14 F; aged 28-69 years). Those with body mass index (BMI) more than 35 kg/m(2) was considered as obese. Serum NO, Ox-LDL and TAA levels of both groups were measured. Results: Serum NO and Ox-LDL levels of the obese subjects were higher than those of the controls whereas serum TAA levels of obese subjects was lower than that of the controls. But the differences between the parameters were not statistically significant. Also, there was no significant correlation between BMI and NO, Ox-LDL and TAA levels in both groups. Conclusion: We found no significant differences between serum NO, Ox-LDL and TAA levels of obese subjects and healty controls and no significant correlation between BMI and above parameters of the subjects. This shows that oxidative stress was not changed in obese people compared to healthy controls which needs to be more investigated.