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Öğe Malondialdehyde levels in adult attention-deficit hyperactivity disorder(CMA-CANADIAN MEDICAL ASSOC, 2007) Bulut, Mahmut; Selek, Salih; Gergerlioglu, H. Serdar; Savas, Haluk A.; Yilmaz, H. Ramazan; Yuce, Murat; Ekici, GiyasettinObjective: To evaluate the biochemical basis of adult attention-deficit hyperactivity disorder (A-ADHD), we compared lipid peroxidation status in the plasma of A-ADHD patients, and that of control subjects without A-ADHD by quantifying the levels of malondialdehyde (MDA), an end product of fatty acid oxidation. We aimed to examine the association between MDA and A-ADHD. Method: The study comprised 20 A-ADHD patients from Gaziantep University Sahinbey Research Hospital Psychiatry Clinic, diagnosed by 2 psychiatrists (H.A.S. and S.S.) according to the Turkish version of the adult ADD/ADHD DSM-IV-Based Diagnostic Screening and Rating Scale, and 21 healthy volunteers. Malondialdehyde levels were measured in plasma samples of both study groups, Results: The mean (standard deviation [SD]) MDA levels in patients (2.44 [0.84] nmol/mL) were significantly higher than those of control subjects (0.36 [0.20] nmol/mL) (t = 11.013, of = 39, p < 0.01). MDA levels were correlated with overall number of criteria met (n = 20, p = 0.01, Ro = 0.56) and total hyperactivity/impulsivity score(n = 20, p = 0.02, Ro = 0.51). Conclusion: The fact that MDA levels were increased in A-ADHD could be an indication of increased oxidative stress in this disease. We suggest that such changes may have a pathological role in A-ADHD. This is the first study evaluating the MDA levels in A-ADHD, and our findings may provide a scientific guide for the further clinical enzymologic and biochemical studies on this disorder.Öğe Oxidative imbalance in adult attention deficit/hyperactivity disorder(ELSEVIER SCIENCE BV, 2008) Selek, Salih; Savas, Haluk A.; Gergerlioglu, H. Serdar; Bulut, Mahmut; Yilmaz, H. RamazanObjective: There are few studies evaluating the biochemical basis of adult attention deficit/hyperactivity disorder (A-ADHD). In the present study, we evaluated whether nitric oxide (NO), an oxidant, level and superoxide dismutase (SOD), an antioxidant, activity are associated with A-ADHD or not. Methods: Twenty A-ADHD patients from Gaziantep University Sahinbey Research Hospital, Psychiatry Clinic, diagnosed according to The Turkish version of Adult ADD/ADHD DSM IV-Based Diagnostic Screening and Rating Scale by two psychiatrists (H.A.S. and S.S.), and twenty-one healthy volunteer controls were included. Blood samples were collected; NO levels and SOD activities were measured. Results: The mean NO levels in patients were significantly higher than those of controls and SOD activity of patients was significantly lower than controls. Conclusions: Remarkable high levels of oxidant NO, and low SOD activities suggest an oxidative imbalance in A-ADHD. This is the first study evaluating the oxidative metabolism in A-ADHD. (C) 2008 Elsevier B.V. All rights reserved.Öğe Oxidative Imbalance in Adult Attention Deficit/Hyperactivity Disorder -- 2(ELSEVIER SCIENCE INC, 2009) Selek, Salih; Savas, Haluk A.; Gergerlioglu, Hasan Serdar; Bulut, Mahmut; Yilmaz, H. Ramazan[Abstract not Available]
