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  • Küçük Resim
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    Effect of tannic acid irrigation on microhardness of root canal dentin and bond strength of epoxy resin based sealer
    (Selçuk Üniversitesi, 2019) Askerbeyli Örs, Sevinc; Aksel, Hacer; Küçükkaya Eren, Selen; Zeybek, Naciye Dilara
    Background: To investigate the effects of final irrigation protocols with tannic acid (TA) on dentin microhardness and push-out bond strength of an epoxy resin based sealer to root canal dentin. Materials and Methods: The 50 root halves were embedded in an acrylic resin for the microhardness measurement. After the initial baseline microhardness measurement the root samples were immersed in 2.5% NaOCl and 17% ethylenediaminetetraacetic acid (EDTA) for 2 min, respectively. Then, the root halves were randomly divided into 5 groups according to the final irrigation protocol used (n=10): distilled water (control), 10% TA for 2 min, 10% TA for 5 min, 20% TA for 2 min, and 20% TA for 5 min. After surface treatment, dentin microhardness values were recorded at close proximity to the initial indentation areas. For push-out bond strength test, the root canals of 75 single-rooted mandibular premolars were instrumented and the irrigation protocols were applied as described above (n = 15). Following root canal obturation with single cone technique using matched-taper gutta percha cones and a epoxy resin based root canal sealer, 1 mm-thick slices were obtained from the middle third of the root canals. Push-out bond strength test was applied. Data were analyzed using one way analysis of variance and Tukey HSD tests (p=0.05). Results: In TA-treated groups, there was a significant increase in the microhardness values compared with the control group (p<0.05) while no significant difference was found among the microhardness values of TA-treated groups (p>0.05). Regarding the push-out bond strength test, there was no significant difference between the bond strength values of 10% TA for 2 min and the control group (p>0.05). The remaining groups presented higher bond strength values than the control group (p<0.05). Conclusion: TA increased dentin microhardness and the bond strength of the epoxy resin based sealer to root canal dentin. The effect on the bond strength was time and concentration dependent.
  • Küçük Resim Yok
    Öğe
    Prophylactic Ozone Administration Reduces Intestinal Mucosa Injury Induced by Intestinal Ischemia-Reperfusion in the Rat
    (HINDAWI LTD, 2015) Onal, Ozkan; Yetisir, Fahri; Sarer, A. Ebru Salman; Zeybek, Naciye Dilara; Onal, C. Oztug; Yurekli, Banu; Celik, H. Tugrul
    Objectives. Intestinal ischemia-reperfusion injury is associated with mucosal damage and has a high rate of mortality. Various beneficial effects of ozone have been shown. The aim of the present study was to show the effects of ozone in ischemia reperfusion model in intestine. Material and Method. Twenty eight Wistar rats were randomized into four groups with seven rats in each group. Control group was administered serum physiologic (SF) intraperitoneally (ip) for five days. Ozone group was administered 1 mg/kg ozone ip for five days. Ischemia Reperfusion (IR) group underwent superior mesenteric artery occlusion for one hour and then reperfusion for two hours. Ozone + IR group was administered 1 mg/kg ozone ip for five days and at sixth day IR model was applied. Rats were anesthetized with ketamine\xyzlazine and their intracardiac blood was drawn completely and they were sacrificed. Intestinal tissue samples were examined under light microscope. Levels of superoxide dismutase (SOD), catalase (CAT), glutathioneperoxidase (GSH-Px), malondyaldehide (MDA), and protein carbonyl (PCO) were analyzed in tissue samples. Total oxidant status (TOS), and total antioxidant capacity (TAC) were analyzed in blood samples. Data were evaluated statistically by Kruskal Wallis test. Results. In the ozone administered group, degree of intestinal injury was not different from the control group. IR caused an increase in intestinal injury score. The intestinal epithelium maintained its integrity and decrease in intestinal injury score was detected in Ozone + IR group. SOD, GSH-Px, and CAT values were high in ozone group and low in IR. TOS parameter was highest in the IR group and the TAC parameter was highest in the ozone group and lowest in the IR group. Conclusion. In the present study, IR model caused an increase in intestinal injury. In the present study, ozone administration had an effect improving IR associated tissue injury. In the present study, ozone therapy prevented intestine from ischemia reperfusion injury. It is thought that the therapeutic effect of ozone is associated with increase in antioxidant enzymes and protection of cells from oxidation and inflammation.