Red Cell Distribution Width Is Independently Related to Endothelial Dysfunction in Patients With Chronic Kidney Disease

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dc.contributor.authorSolak, Yalcin
dc.contributor.authorYilmaz, Mahmut I.
dc.contributor.authorSaglam, Mutlu
dc.contributor.authorCaglar, Kayser
dc.contributor.authorVerim, Samet
dc.contributor.authorUnal, Hilmi U.
dc.contributor.authorGok, Mahmut
dc.date.accessioned2020-03-26T18:58:27Z
dc.date.available2020-03-26T18:58:27Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground:Red cell distribution width (RDW) is a measure of erythrocyte size variability and has been shown as an independent predictor of mortality. The aim of this article was to evaluate the association of RDW with endothelial dysfunction in patients with chronic kidney disease (CKD).Methods:Patients with 1 to 5 stages of CKD were included in the study. Endothelial function was assessed with flow-mediated dilatation (FMD). Estimated glomerular filtration rate (eGFR) and carotid intima media thickness (CIMT) were determined. Clinicodemographic characteristics, biochemical values, complete blood counts, ferritin, C-reactive protein (CRP) and cholesterol levels were recorded. Spearman's correlation was used to determine correlates of RDW. Multivariate linear regression model was used to assess independent associates of FMD.Results:Overall, 367 patients with CKD 1 to 5 were included in the study. RDW showed a significant increase from stage 1 to stage 5 CKD. Median RDW was 13.5. Patients with RDW values higher than median had significantly lower hemoglobin, eGFR and FMD values and higher CIMT and CRP values compared with patients who had RDW values below median. RDW showed a significant positive correlation with the presence of diabetes mellitus, CIMT and CRP, whereas a significant negative correlation with eGFR, ferritin and FMD. Multivariate analysis showed independent predictors of FMD as RDW, presence of diabetes, hemoglobin, eGFR, CRP, and serum albumin.Conclusions:Multivariate regression model revealed RDW as a significant predictor of FMD independent of major confounding factors, such as diabetes, inflammation, anemia and kidney function in CKD.en_US
dc.description.sponsorshipERA-EDTA Long-Term Fellowship Granten_US
dc.description.sponsorshipSupported by ERA-EDTA Long-Term Fellowship Grant (to A.G.).en_US
dc.identifier.doi10.1097/MAJ.0b013e3182996a96en_US
dc.identifier.endpage124en_US
dc.identifier.issn0002-9629en_US
dc.identifier.issn1538-2990en_US
dc.identifier.issue2en_US
dc.identifier.pmid23928544en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage118en_US
dc.identifier.urihttps://dx.doi.org/10.1097/MAJ.0b013e3182996a96
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31107
dc.identifier.volume347en_US
dc.identifier.wosWOS:000331296100005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofAMERICAN JOURNAL OF THE MEDICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectRed cell distribution widthen_US
dc.subjectEndothelial functionen_US
dc.subjectFlow-mediated dilatationen_US
dc.subjectChronic kidney diseaseen_US
dc.titleRed Cell Distribution Width Is Independently Related to Endothelial Dysfunction in Patients With Chronic Kidney Diseaseen_US
dc.typeArticleen_US

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