Chemical Composition and Anticholinesterase Activity of Lagochilus Inebrians

The plant genus Lagochilus (Lamiaceae) comprises 44 species that are broadly distributed over Central Asia with 18 species occurring in the flora of Uzbekistan [1]. Tincture of the herb and roots of L. inebrians Bunge, which is indigenous in Uzbekistan [2], are used in folk medicine as a sedative, analgesic, and hemostatic agent [3]. The hemostatic activity is due to the diterpene alcohol lagochilin. Hemostatic materials based on this compound were fabricated [4]. Diterpenes (lagochilin and its acetates) [5,6,7] and iridoids (8-O-acetylharpagide and harpagide) [8] were observed in L. inebrians. However, the chemical composition of this plant is inadequately studied. The enzyme-inhibiting activity has not been studied.