Plasma leptin levels increase to a greater extent following on-pump coronary artery surgery in type 2 diabetic patients than in nondiabetic patients

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dc.contributor.authorGuvener, Murat
dc.contributor.authorUcar, Halil Ibrahim
dc.contributor.authorOc, Mehmet
dc.contributor.authorPinar, Asli
dc.date.accessioned2020-03-26T18:31:03Z
dc.date.available2020-03-26T18:31:03Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAims: We aimed to evaluate whether leptin and ghrelin responses to cardiopulmonary bypass (CPB) are dependent on type 2 diabetes and whether these responses are associated with interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP), cortisol and insulin. Methods: We examined stress-response patterns in plasma leptin, ghrelin, hsCRP, IL-6, cortisol and insulin levels before and up to 5 days after cardiopulmonary bypass in 20 patients with type 2 diabetes and 20 patients without diabetes. Results: Plasma leptin levels increased significantly in both groups (p < 0.05) and rose significantly higher in diabetics when compared with nondiabetic patients (p = 0.004). Plasma ghrelin levels increased significantly only in diabetics (p = 0.033). Patients with and without diabetes showed significantly elevated serum concentrations of IL-6, hsCRP, cortisol and insulin (p < 0.005 for IL-6, hsCRP; p < 0.05 for cortisol, insulin) but the difference between the two groups was nonsignificant. Leptin was independently predicted by hsCRP (p < 0.05, F = 2.9), gender (women p < 0.001, F = 4.7), body mass index (BMI p < 0.0001, F = 6.1) whereas ghrelin levels were not associated with any variables in the total patient population. (critical F = 2.26, p <= 0.05). Conclusions: Acute phase response in diabetics differs by higher leptin levels independent of BMI, gender and IL-6, hsCRP, insulin and cortisol levels. (C) 2012 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.diabres.2012.01.008en_US
dc.identifier.endpage378en_US
dc.identifier.issn0168-8227en_US
dc.identifier.issue3en_US
dc.identifier.pmid22284601en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage371en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.diabres.2012.01.008
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28310
dc.identifier.volume96en_US
dc.identifier.wosWOS:000305281100026en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER IRELAND LTDen_US
dc.relation.ispartofDIABETES RESEARCH AND CLINICAL PRACTICEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCardiopulmonary bypassen_US
dc.subjectDiabetes mellitusen_US
dc.subjectAcute phase reactantsen_US
dc.subjectLeptinen_US
dc.subjectGhrelinen_US
dc.titlePlasma leptin levels increase to a greater extent following on-pump coronary artery surgery in type 2 diabetic patients than in nondiabetic patientsen_US
dc.typeArticleen_US

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