PlasmaBNP, a useful marker of fluid overload in hospitalized hemodialysis patients

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dc.contributor.authorCelik, Gulperi
dc.contributor.authorSilinou, Emilie
dc.contributor.authorVo-Van, Cyril
dc.contributor.authorJean, Guillaume
dc.contributor.authorChazot, Charles
dc.date.accessioned2020-03-26T18:31:03Z
dc.date.available2020-03-26T18:31:03Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractHospitalization for intercurrent illness frequently disrupts the nutritional status of hemodialysis (HD) patients and jeopardizes the dry weight prescription. We report in this study the evolution of brain natriuretic peptide (BNP), blood pressure and body weight in hospitalized patients and the relationship between BNP plasma level and nutritional and inflammation parameters. We have studied 42 patients requiring hospitalization (F/M: 18/24; 72.5 +/- 12.5 years old; 19/42 with diabetes). The plasma BNP levels at baseline, during hospitalization (BNP-Hosp), and in the recovery phase were compared. Predialysis and postdialysis blood pressure and postdialysis body weight were recorded and compared. BNP-Hosp increased significantly when compared with BNP levels at baseline, from 421 +/- 647.2 pg/mL to 1584 +/- 1584.4 pg/mL (P < 0.0001). Brain natriuretic peptide decreased from 1223 +/- 1342.1 pg/mL during hospitalization to 616 +/- 892.1 pg/mL after discharge (P = 0.005). The BNP-Hosp was positively correlated with C-reactive protein (P = 0.003) and negatively correlated with serum prealbumin (P = 0.0001) and albumin (P = 0.0001). The postdialysis body weight prescription decreased from 71.0 +/- 15.7 kg at baseline to 70.5 +/- 15.4 kg during hospitalization and to 67.8 +/- 14.4 kg 4 months after discharge (P = 0.0032). Our study displays clearly the significant changes of plasma BNP levels occurring during intercurrent events. Fluid overload triggered by inflammation-associated catabolism and the lag time for dry weight adjustment is the cause of this finding. Hence, plasma BNP level may be used as a marker of fluid overload in patients with intercurrent events and may allow efficient dry weight adjustment. We cannot rule out an effect of inflammation on BNP synthesis.en_US
dc.identifier.doi10.1111/j.1542-4758.2011.00627.xen_US
dc.identifier.endpage52en_US
dc.identifier.issn1492-7535en_US
dc.identifier.issn1542-4758en_US
dc.identifier.issue1en_US
dc.identifier.pmid22099627en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1542-4758.2011.00627.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28312
dc.identifier.volume16en_US
dc.identifier.wosWOS:000299636400008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofHEMODIALYSIS INTERNATIONALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBNPen_US
dc.subjectcatabolismen_US
dc.subjectfluid overloaden_US
dc.subjectinflammationen_US
dc.subjectCRPen_US
dc.subjectprealbuminen_US
dc.titlePlasmaBNP, a useful marker of fluid overload in hospitalized hemodialysis patientsen_US
dc.typeArticleen_US

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