Micronucleus Incidence and Their Chromosomal Origin Related to Therapy in Acute Lymphoblastic Leukemia (ALL) Patients: Detection by Micronucleus and FISH Techniques

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dc.contributor.authorAcar, Hasan
dc.contributor.authorÇalışkan, Ümran
dc.contributor.authorDemirel, Şennur
dc.contributor.authorLargaespada, David A.
dc.date.accessioned2020-03-26T16:37:15Z
dc.date.available2020-03-26T16:37:15Z
dc.date.issued2001
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractMicronucleus assay and dual color-fluorescence in situ hybridization (DC-FISH), using centromere-specific and whole chromosome-specific painting probes, are considered a useful screening test to determine the incidence of micronucleus, their origin and contents. The patients with acute lymphoblastic leukemia (ALL), who had undergone chemotherapy, were analysed before and after treatment with vincristine, methotrexate, daunomycin, prednisone, and asparaginase. The incidence of micronuclei after the antileukemic agent treatment was significantly higher than before the treatment. Application of DC-FISH using a combination of whole chromosome-specific painting probes and the same chromosome-specific a-satellite centromeric probe showed that there were no significant differences in the micronucleus incidence for any specific chromosome (chromosomes 7, 8, 11, 17, X, and Y). There were no significant differences between the incidence of centromere-positive micronuclei and the incidence of centromere-negative micronucleus. We concluded that antileukemic agents induced the somatic genetic damage but this damage is not related to any specific chromosome studied.en_US
dc.identifier.citationAcar, H., Çalışkan, Ü., Demirel, Ş., Largaespada, D. A., (2001). Micronucleus Incidence and Their Chromosomal Origin Related to Therapy in Acute Lymphoblastic Leukemia (ALL) Patients: Detection by Micronucleus and FISH Techniques. Teratogenesis Carcinogenesis and Mutagenesis, 21(5), 341-347. Doi:10.1002/tcm.1022
dc.identifier.doi10.1002/tcm.1022en_US
dc.identifier.endpage347en_US
dc.identifier.issn0270-3211en_US
dc.identifier.issue5en_US
dc.identifier.pmid11746248en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage341en_US
dc.identifier.urihttps://dx.doi.org/10.1002/tcm.1022
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17573
dc.identifier.volume21en_US
dc.identifier.wosWOS:000170898200004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAcar, Hasan
dc.institutionauthorÇalışkan, Ümran
dc.institutionauthorDemirel, Şennur
dc.language.isoenen_US
dc.publisherWILEY-LISSen_US
dc.relation.ispartofTeratogenesis Carcinogenesis and Mutagenesisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectALLen_US
dc.subjectAntileukemic Agentsen_US
dc.subjectMicronucleusen_US
dc.subjectFISHen_US
dc.titleMicronucleus Incidence and Their Chromosomal Origin Related to Therapy in Acute Lymphoblastic Leukemia (ALL) Patients: Detection by Micronucleus and FISH Techniquesen_US
dc.typeArticleen_US

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