Lipid peroxidation and paraoxonase activity in nocturnal cyclic and sustained intermittent hypoxia

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dc.contributor.authorOkur, Hacer Kuzu
dc.contributor.authorPelin, Zerrin
dc.contributor.authorYuksel, Meral
dc.contributor.authorYosunkaya, Sebnem
dc.date.accessioned2020-03-26T18:42:22Z
dc.date.available2020-03-26T18:42:22Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) have been known to be associated with atherosclerosis and hypoxia which was suggested to have an important role in this process by the way of increased oxidative stress. In the present study, we aimed to evaluate the effects of nocturnal hypoxia pattern (intermittent versus sustained) on serum lipid peroxidation and paraoxonase (PON) activity. Blood collections were performed in 44 OSA, 11 non-apneic, nocturnal desaturated COPD, and 14 simple snorer patients after full-night polysomnographic recordings. Nocturnal sleep and respiratory parameters, oxygen desaturation indexes, serum malondialdehyde (MDA) levels by measuring with the help of the formation of thiobarbituric acid reactive substances (TBARS), and PON activity were assessed in all subjects. OSA and COPD patients showed nocturnal hypoxemia, with a minimum oxygen saturation (SaO(2)) in ranges of 53-92 % and 50-87 %, respectively. The mean levels of TBARS was 15.7 +/- 3.6 nmol and 15.3 +/- 3.4 nmol malondialdehyde (MDA)/ml in OSA and COPD patients, respectively, while the mean level of the control group was 4.1 +/- 1.2 nmol MDA/ml. The mean PON activity was found to be 124.2 +/- 35.5 U/l in OSA patients and 124.6 +/- 28.4 U/l in COPD patients. The mean PON activity of the control group was 269.0 +/- 135.8 U/l. The increase in TBARS levels and the decrease in PON1 levels were statistically significant in both OSA and COPD patients according to controls (p < 0.001 for TBARS as well as PON1). The results of this study revealed that both OSA and non-apneic, nocturnal desaturated COPD patients showed increased levels of lipid peroxidation and decreased PON activity despite the differences in nocturnal hypoxia pattern.en_US
dc.identifier.doi10.1007/s11325-012-0703-5en_US
dc.identifier.endpage371en_US
dc.identifier.issn1520-9512en_US
dc.identifier.issn1522-1709en_US
dc.identifier.issue1en_US
dc.identifier.pmid22528954en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage365en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s11325-012-0703-5
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29616
dc.identifier.volume17en_US
dc.identifier.wosWOS:000315167200056en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGER HEIDELBERGen_US
dc.relation.ispartofSLEEP AND BREATHINGen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIntermittent hypoxiaen_US
dc.subjectObstructive sleep apneaen_US
dc.subjectChronic obstructive pulmonary diseaseen_US
dc.subjectParaoxonaseen_US
dc.subjectLipid peroxidationen_US
dc.subjectOxidative stressen_US
dc.titleLipid peroxidation and paraoxonase activity in nocturnal cyclic and sustained intermittent hypoxiaen_US
dc.typeArticleen_US

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