Synthesis and evaluation of antioxidant, antimicrobial and anticancer properties of 2-(prop-2-yn-1-yloxy)benzaldehyde derivatives

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dc.contributor.authorKonus M.
dc.contributor.authorAydemir S.
dc.contributor.authorYilmaz C.
dc.contributor.authorKivrak A.
dc.contributor.authorKizildogan A.K.
dc.contributor.authorArpaci P.U.
dc.date.accessioned2020-03-26T20:20:01Z
dc.date.available2020-03-26T20:20:01Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesien_US
dc.description.abstract5-bromo-2-(prop-2-yn-1-yloxy)benzaldehyde (compound 3) and 3,5-di-tert-butyl-2-(prop-2- yn-1-yloxy)benzaldehyde (compound 5) were synthesized via nucleophilic substitution reactions. Compound 5 showed higher antioxidant capacity with respect to compound 3 in all the four different antioxidant activity methods used. Moreover, in phosphomolybdenum assay, compound 5, with 1.1 proportion value, showed almost the same total antioxidant capacity compared to universal trolox standard. Furthermore, Broth microdilution method and agar disc diffusion tests demonstrated that the same compound also exhibited good antibacterial activity towards the bacteria Bacillus subtilis. Finally, both of the benzaldehyde compounds showed high antifungal activity against Aspergillus niger. In this study, compound 5 (IC50: 54.3 µg/ml) showed significant cytotoxic activity against breast adenocarcinoma cell line MCF-7 with respect to compound 3 (IC50: 173.4 µg/ml). © 2019 Bentham Science Publishers.en_US
dc.description.sponsorshipWe thank to Van Yüzüncü Yıl University (BAP 2015-FBE-YL364 and FBA-2016-5292) for the generous financial support.en_US
dc.identifier.doi10.2174/1570178616666181116100232en_US
dc.identifier.endpage423en_US
dc.identifier.issn1570-1786en_US
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage415en_US
dc.identifier.urihttps://dx.doi.org/10.2174/1570178616666181116100232
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38481
dc.identifier.volume16en_US
dc.identifier.wosWOS:000462832500005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBentham Science Publishers B.V.en_US
dc.relation.ispartofLetters in Organic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subject2-(prop-2-yn-1-yloxy)benzaldehydeen_US
dc.subjectAntibacterialen_US
dc.subjectAnticanceren_US
dc.subjectAntifungalen_US
dc.subjectAntioxidanten_US
dc.subjectHuman breast carcinomaen_US
dc.titleSynthesis and evaluation of antioxidant, antimicrobial and anticancer properties of 2-(prop-2-yn-1-yloxy)benzaldehyde derivativesen_US
dc.typeArticleen_US

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