Intracranial hemorrhage due to vitamin K deficiency after the newborn period

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dc.contributor.authorDemiroren, K
dc.contributor.authorYavuz, H
dc.contributor.authorCam, L
dc.date.accessioned2020-03-26T16:55:20Z
dc.date.available2020-03-26T16:55:20Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study presents clinical and laboratory findings and outcome of infants with intracranial hemorrhage (ICH) due to vitamin K deficiency after the newborn period, and evaluates vitamin K prophylaxis. The hospital records of 19 infants with a diagnosis of ICH due to vitamin K deficiency after the newborn period, seen in our clinic in less than 4 years, were retrospectively evaluated. The mean age at onset of the symptoms was 49+/-18 days. The most frequent presenting complaints were convulsion (58%), vomiting (47%), and irritability (47%). The most frequent examination findings were coma (74%), fontanel bulging (68%), and absence of pupil reaction (42%). The localizations of the ICHs were as follows: parenchymal (47%), subarachnoid (47%), subdural (42%), and intraventricular (26%). Four patients had used antibiotics and 1 patient had suffered diarrhea before the onset of the symptoms. One patient had a mild hepatic dysfunction that resolved spontaneously in a few weeks and its cause was not found. Mortality was observed in 6 (32%) patients. Ten patients were followed up for a mean period of 26.9+/-22.6 months. The follow-up findings were developmental delay (40%), microcephaly (30%), epilepsy (30%), blindness (20%), strabismus (20%), spastic tetraparesis (10%), spastic hemiparesis (10%), growth retardation (10%), and hydrocephaly (10%). Three (30%) patients remained neurologically normal. Vitamin K deficiency leads to death and neurological defects. Vitamin K prophylaxis at birth is therefore a priority. In this series, hepatic dysfunction had been detected in only 1 patient. The authors speculate that additional vitamin K to breast-fed infants with liver problem, antibiotic use, diarrhea, etc. should be considered.en_US
dc.identifier.doi10.1080/08880010490500944en_US
dc.identifier.endpage592en_US
dc.identifier.issn0888-0018en_US
dc.identifier.issue7en_US
dc.identifier.pmid15626014en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage585en_US
dc.identifier.urihttps://dx.doi.org/10.1080/08880010490500944
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19105
dc.identifier.volume21en_US
dc.identifier.wosWOS:000223843200002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.relation.ispartofPEDIATRIC HEMATOLOGY AND ONCOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectintracranial hemorrhageen_US
dc.subjectvitamin Ken_US
dc.titleIntracranial hemorrhage due to vitamin K deficiency after the newborn perioden_US
dc.typeArticleen_US

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