Effect of N(4)-substituent groups on transfer of 2-benzoylpyridine thiosemicarbazone derivates at the water/1,2-dichloroethane interface

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dc.contributor.authorAkgemci, Emine Güler
dc.contributor.authorBingöl, Haluk
dc.contributor.authorAtalay, T.
dc.contributor.authorErsöz, A.
dc.date.accessioned2020-03-26T17:17:18Z
dc.date.available2020-03-26T17:17:18Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractDependent on the pH of the aqueous phase, the transfer of protonated forms of 2-benzoylpyridine N(4)-phenyl thiosemicarbazone (BPPT) (which has antimicrobial, antifungal and anticytotoxic activities) and 2-benzoylpyridine N(4)-ethyl thiosemicarbazone (BPET) across water/1,2dichloroethane (1,2-DCE) interface has been studied by cyclic voltarnmetry. The protonation constants of the ligands (pK(a1)(w) and pK(a2)(w)) were a I a2 determined by spectrophotometry. The standard partition coefficients (log P-i(0)) and the standard Gibbs energies of ionic (cationic) species of ligands (Delta G(tr,i)(0,w -> o)) were calculated from the standard transfer potentials (Delta(w)(o)phi(0)(i)). The standard Gibbs energies of their transfer (Delta G(tr,i)(0,w -> o)) and partition coefficients of neutral species (log P-N) were determined by shake-flask method. These thermodynamic parameters were evaluated as a quantitative and qualitative measure of the lipophilicities of two compounds. The differences between the partition coefficients of cationic and neutral form of compounds [diff(log P1+-N)] were interpreted by results obtained from voltammetric data. Effect of N(4)-phenyl and ethyl groups for transfer of 2-benzoylpyridine thiosemicarbazone derivatives at macro-liquid/liquid interface was investigated. The antimicrobial activity of BPET was tested against four types of bacteria and found to be active against Staphlylococcus aureus. (c) 2007 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.electacta.2007.07.028en_US
dc.identifier.endpage679en_US
dc.identifier.issn0013-4686en_US
dc.identifier.issn1873-3859en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage673en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.electacta.2007.07.028
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21348
dc.identifier.volume53en_US
dc.identifier.wosWOS:000251480900054en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofELECTROCHIMICA ACTAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subject2-benzoylpyridine thiosemicarbazoneen_US
dc.subjectN(4)-substituenten_US
dc.subjectcyclic voltammetryen_US
dc.subjectlipophilicityen_US
dc.subjectliquid/liquid interfaceen_US
dc.titleEffect of N(4)-substituent groups on transfer of 2-benzoylpyridine thiosemicarbazone derivates at the water/1,2-dichloroethane interfaceen_US
dc.typeArticleen_US

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