An investigation of micronucleus induction by butylated hydroxytoluene in wistar rat bone marrow cells

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dc.contributor.authorPolat, Fikriye
dc.contributor.authorBingol, Gunsel
dc.contributor.authorTuraclar, Nesrin
dc.date.accessioned2020-03-26T18:49:21Z
dc.date.available2020-03-26T18:49:21Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümüen_US
dc.description.abstractThis study aims to investigate whether Butylated Hydroxytoluene (BHT), the synthetic antioxidant and food additive, increases the frequency of micronucleated polychromatic erythrocytes (MNPCEs) in rat bone marrow. BHT, dissolved in corn oil, was administered intraperitoneally to 8-10 week old male and female Wistar rats (n=36) in three different doses (125, 250 and 500 mg/kg b.w.) for two different time periods. 12- and 24-h after BHT treatment, the bone marrow samples were analyzed for the frequency of MNPCEs. Additionally, by evaluating the ratio of polychromatic erythrocyte to normochromatic erythrocyte (PCE/NCE), the cytotoxic effect of BHT on bone marrow was tested. It was found that all BHT doses at two time periods significantly increased the MNPCEs frequency about 1.9-2.84 fold. On the other hand, BHT caused significant decreased in the PCE/NCE ratio, which is indicative of bone marrow cytotoxicity when compared to the control groups. This study showed that BHT increased the formation of MNPCEs in rat bone marrow and we think that this increase might be related to the applied doses and the administration way BHT.en_US
dc.description.sponsorshipScientific Research Project Council of Kocaeli UniversityKocaeli University [2010-84]en_US
dc.description.sponsorshipThis study was financially supported by the Scientific Research Project Council of Kocaeli University (Project number: 2010-84)en_US
dc.identifier.citationPolat, F., Bingöl, G., Turaçlar, N. (2014). An Investigation of Micronucleus Induction by Butylated Hydroxytoluene in Wistar Rat Bone Marrow Cells. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 20(4), 527-531.
dc.identifier.doi10.9775/kvfd.2013.10521en_US
dc.identifier.endpage531en_US
dc.identifier.issn1300-6045en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage527en_US
dc.identifier.urihttps://dx.doi.org/10.9775/kvfd.2013.10521
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30591
dc.identifier.volume20en_US
dc.identifier.wosWOS:000344687800008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorTuraclar, Nesrin
dc.language.isoenen_US
dc.publisherKAFKAS UNIV, VETERINER FAKULTESI DERGISIen_US
dc.relation.ispartofKAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectButylated hydroxytolueneen_US
dc.subjectCytotoxicityen_US
dc.subjectGenotoxicityen_US
dc.subjectMicronucleusen_US
dc.titleAn investigation of micronucleus induction by butylated hydroxytoluene in wistar rat bone marrow cellsen_US
dc.typeArticleen_US

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