Analysis of Tears in Patients with Atopic Keratoconjunctivitis, Using Flow Cytometry

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dc.contributor.authorAvunduk, Avni Murat
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorTekelioğlu, Yavuz
dc.date.accessioned2020-03-26T16:26:04Z
dc.date.available2020-03-26T16:26:04Z
dc.date.issued1998
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAtopic keratoconjunctivitis (AKC) is a chronic allergic eye disease, Although the pathogenesis is not fully understood, some impairment in cell-mediated immunity was suggested by histopathological findings in conjunctival specimens obtained from affected individuals. T-cell infiltration and an enhanced T-helper/T-suppressor cell ratio in conjunctival biopsy specimens were observed previously by immunofluorescence procedures, We analyzed the cells in tears of patients with AKC using flow cytometry (FCM) and compared the results to those of normal subjects to identify the role of T lymphocytes in the pathogenesis of the disease, The tear samples of the patients and normal subjects were collected with capillary tubes, and the surface receptors of cells were detected with FCM. Statistical analyses were performed with Student's t test, The percentages of T cells, activated B cells, and T-helper/T-suppressor cell ratios were found to be higher in the tears of patients with AKC than in controls, We propose that a decreased T-suppressor cell concentration in tears may enhance immunoglobulin-E production of B cells, and the signs and symptoms are provoked by inflammatory mediators liberated from mast cell degranulation.en_US
dc.identifier.citationAvunduk, M. C., Avunduk, A. M., Tekelioğlu, Y., (1998). Analysis of Tears in Patients with Atopic Keratoconjunctivitis, Using Flow Cytometry. Ophthalmic Research, 30(1), 44-48.
dc.identifier.endpage48en_US
dc.identifier.issn0030-3747en_US
dc.identifier.issue1en_US
dc.identifier.pmid9483587en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage44en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16747
dc.identifier.volume30en_US
dc.identifier.wosWOS:000071783100006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAvunduk, Mustafa Cihat
dc.language.isoenen_US
dc.publisherKARGERen_US
dc.relation.ispartofOphthalmic Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecthumanen_US
dc.subjectconjunctivaen_US
dc.subjecttear analysisen_US
dc.subjectatopic keratoconjuctivitisen_US
dc.subjectflow cytometryen_US
dc.subjecthelper T lymphocyteen_US
dc.subjectsuppressor T lymphocyteen_US
dc.subjectactivated B lymphocyteen_US
dc.titleAnalysis of Tears in Patients with Atopic Keratoconjunctivitis, Using Flow Cytometryen_US
dc.typeArticleen_US

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