Uric Acid in Hypertension and Renal Disease: The Chicken or the Egg?

Basit Öğe Kaydı
dc.contributor.authorKanbay, Mehmet
dc.contributor.authorSolak, Yalcin
dc.contributor.authorDogan, Ekrem
dc.contributor.authorLanaspa, Miguel A.
dc.contributor.authorCovic, Adrian
dc.date.accessioned2020-03-26T18:05:32Z
dc.date.available2020-03-26T18:05:32Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAfter uric acid was recognized as the causative factor in gout, increased prevalence of renal disease and hypertension in this patient population caught the attention of the medical community. Thus, it has been proposed that uric acid might have caused these disorders. However, uric acid suffered a long period of ignorance in which it was considered a metabolically inert substance. However, recent years has witnessed a resurrection of interest. Experimental studies showed an association between increased uric acid and renal arteriolar disease and hypertension. These preliminary results were supported with clinical studies. However, controversy regarding the precise pathophysiologic role of uric acid in inducing hypertension and renal disease remains to be elucidated. Despite being limited at this time, a few randomized intervention studies showed that even treatment of asymptomatic hyperuricemia was beneficial in terms of blood pressure regulation and kidney function. In this review, we focus on the pathophysiologic role of uric acid in the development and progression of renal disease and hypertension. We also discuss recent clinical evidence suggesting a causal role of uric acid in these disease states. Copyright (C) 2010 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000321074en_US
dc.identifier.endpage295en_US
dc.identifier.issn0253-5068en_US
dc.identifier.issn1421-9735en_US
dc.identifier.issue4en_US
dc.identifier.pmid21088389en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage288en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000321074
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25455
dc.identifier.volume30en_US
dc.identifier.wosWOS:000285817000006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKARGERen_US
dc.relation.ispartofBLOOD PURIFICATIONen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectHypertensionen_US
dc.subjectRenal diseaseen_US
dc.subjectUric aciden_US
dc.titleUric Acid in Hypertension and Renal Disease: The Chicken or the Egg?en_US
dc.typeReviewen_US

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