Plasma kisspeptin and ghrelin levels in puberty variant cases

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dc.contributor.authorKurnaz, Erdal
dc.contributor.authorSen, Yasar
dc.contributor.authorAydin, Suleyman
dc.date.accessioned2020-03-26T19:42:20Z
dc.date.available2020-03-26T19:42:20Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: The aim of this study was to determine the serum levels of kisspeptin and ghrelin (GAH), as well as the relationship of these two peptides with each other in premature thelarche (PT) and premature adrenarche (PA) cases and to investigate the possibility of using these peptides as markers in the differentiation of puberty disorders. Methods: A PT group aged 1-8 years (n = 40), a PA group aged 1-9 years (n = 23, female/male = 20/3) and control groups consistent with each of the previous groups in terms of age and gender were created for the study. Kisspeptin and ghrelin levels were measured with ELISA methods from blood samples drawn while fasting in the morning. Results: When the PT group was compared with the controls, the plasma kisspeptin levels of the cases were significantly higher than the control group (165.47 +/- 15.45 pmol/L, 96.82 +/- 12.33 pmol/L, p = 0.005, respectively). Kisspeptin levels in the PA group did not show a difference with the control group (121.36 +/- 17.99 pmol/L, 95.52 +/- 11.54 pmol/L, p = 0.249, respectively). No significant difference could be found when GAH levels in the PT and PA groups were compared with controls. No significant correlation was found between kisspeptin and GAH levels in the PT and PA groups. Conclusions: Our results indicate that kisspeptin plays an important role in the PT, but GAH is not associated with puberty disorders.en_US
dc.description.sponsorshipFirat University Scientific Research Projects Coordination Unit [1849]en_US
dc.description.sponsorshipFunding for this study was provided by the Firat University Scientific Research Projects Coordination Unit (Project no: 1849).en_US
dc.identifier.doi10.1515/jpem-2016-0127en_US
dc.identifier.endpage573en_US
dc.identifier.issn0334-018Xen_US
dc.identifier.issn2191-0251en_US
dc.identifier.issue5en_US
dc.identifier.pmid28422705en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage569en_US
dc.identifier.urihttps://dx.doi.org/10.1515/jpem-2016-0127
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35385
dc.identifier.volume30en_US
dc.identifier.wosWOS:000400461100011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWALTER DE GRUYTER GMBHen_US
dc.relation.ispartofJOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISMen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectghrelin (GAH)en_US
dc.subjectkisspeptinen_US
dc.subjectpremature adrenarche (PA)en_US
dc.subjectpremature thelarche (PT)en_US
dc.titlePlasma kisspeptin and ghrelin levels in puberty variant casesen_US
dc.typeArticleen_US

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