Influence of Dexamethasone on Nausea and Vomiting During Patient-controlled Analgesia With Tramadol

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dc.contributor.authorTuncer, Sema
dc.contributor.authorBarışkaner, Hülagü
dc.contributor.authorYosunkaya, Alper
dc.contributor.authorTavlan, Aybars
dc.date.accessioned2020-03-26T16:39:12Z
dc.date.available2020-03-26T16:39:12Z
dc.date.issued2002
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to evaluate the prophylactic effect of dexamethasone on postoperative nausea and vomiting (PONV) during patient-controlled analgesia (PCA) with tramadol. Methods: 50 patients [American Society of Anesthesiologists (ASA) I-II] were enrolled in this randomised, placebo-controlled study. In group 1, saline was administered as a control. In group II, 150 mug/kg dexamethasone was administered as an intravenous bolus and then tramadol added in the PCA device. We assessed PONV and the need for rescue antiemetics in the 24 hours postoperatively. Results: 17 of 25 dexamethasone-treated patients (68%) had no nausea, four patients (16%) experienced nausea, two patients (8%) retched, two patients (8%) vomited once, no patients vomited repeatedly and seven patients (28%) required rescue antiemetics. In the placebo-treated group, three of 25 patients (12%) had no nausea, 12 (48%) had nausea, three (12%) retched, three patients (12%) vomited once, four patients (16%) vomited repeatedly and 17 patients (68%) required a rescue antiemetic, The incidence of nausea, vomiting and administration of a rescue antiemetic were significantly less in dexamethasone recipients compared with the saline-treated group (p < 0.05). There were no significant differences between the groups in the pain score results or in the consumption of tramadol. Conclusion: Our results demonstrate that a single dose of dexamethasone reduced the incidence of PONV during PCA with tramadol.en_US
dc.identifier.citationTuncer, S., Barışkaner, H., Yosunkaya, A., Tavlan, A., (2002). Influence of Dexamethasone on Nausea and Vomiting During Patient-controlled Analgesia With Tramadol. Clinical Drug Investigation, 22(8), 547-552. Doi: 10.2165/00044011-200222080-00007
dc.identifier.doi10.2165/00044011-200222080-00007en_US
dc.identifier.endpage552en_US
dc.identifier.issn1173-2563en_US
dc.identifier.issn1179-1918en_US
dc.identifier.issue8en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage547en_US
dc.identifier.urihttps://dx.doi.org/10.2165/00044011-200222080-00007
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17975
dc.identifier.volume22en_US
dc.identifier.wosWOS:000177548400007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorTuncer, Sema
dc.institutionauthorBarışkaner, Hülagü
dc.institutionauthorYosunkaya, Alper
dc.institutionauthorTavlan, Aybars
dc.language.isoenen_US
dc.publisherAdis Int Ltden_US
dc.relation.ispartofClinical Drug Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleInfluence of Dexamethasone on Nausea and Vomiting During Patient-controlled Analgesia With Tramadolen_US
dc.typeArticleen_US

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