Further Studies on the Immunopathology of Atopic Keratoconjunctivitis Using Flow Cytometry

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dc.contributor.authorAvunduk, Avni Murat
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorDayanır, Volkan
dc.contributor.authorTekelioğlu, Yavuz
dc.date.accessioned2020-03-26T16:25:24Z
dc.date.available2020-03-26T16:25:24Z
dc.date.issued1997
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAtopic keratoconjunctivitis (AKC) is an ocular manifestation of systemic hypersensitivity. Although the pathogenesis of AKC is not fully understood, some previous data suggest that a decrease in numbers of suppressor T lymphocyte (Ts) and increase of Th, especially Th2 (the second subgroup of helper T lymphocyte), at the ocular surface may play an important role in the occurrence of the disease. In this study, the percentages of naive-Th (CD4/45RA +) and memory-Th (CD4/29 +) cells, and the Th/Ts and memory-Th cells/naive-Th cells ratios were measured in the blood and tear samples of patients with AKC, atopic patients without ocular involvement and normal volunteers, using flow cytometry. Groups were compared using the Mann-Whitney U test. We found that patients with AKC had significantly higher memory-Th cell concentration, and Th/Ts and memory-Th cells/naive-Th cell ratios both in the tear and blood samples compared to normal subjects. While no significant difference existed between the tear samples of the atopic patients without ocular involvement and normal volunteers with respect to the above values, atopic patients had higher percentages of memory-Th cells and higher Th/Ts and memory-TH cells/naive-Th ratios in their blood than normal subjects. The percentages of memory-Th cells, and the Th/Ts and memory-Th cells/naive-Th cell ratios in the tear samples of AKC patients were also found to be higher than that of the atopic patients without ocular involvement, but no significant difference was present between the blood samples of these groups. The percentages of naive-Th cells did not show any significant difference between groups either in tear or blood samples. Since the mean memory-Th cells/naive-Th1 cells ratio in the tear samples of the patients with AKC was higher than in their blood samples, we propose that the localized accumulation of memory-Th2 cells, in addition to the increase of Th/Ts ratios in the external eye may cause AKC in atopic individuals.en_US
dc.identifier.citationAvunduk, A. M., Avunduk, M. C., Dayanır, V., Tekelioğlu, Y., (1997). Further Studies on the Immunopathology of Atopic Keratoconjunctivitis Using Flow Cytometry. Experimental Eye Research, 65(6), 803-808.
dc.identifier.doi10.1006/exer.1997.0398en_US
dc.identifier.endpage808en_US
dc.identifier.issn0014-4835en_US
dc.identifier.issue6en_US
dc.identifier.pmid9441704en_US
dc.identifier.startpage803en_US
dc.identifier.urihttps://dx.doi.org/10.1006/exer.1997.0398
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16584
dc.identifier.volume65en_US
dc.identifier.wosWOS:000071179700009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAvunduk, Mustafa Cihat
dc.language.isoenen_US
dc.publisherACADEMIC PRESS LTDen_US
dc.relation.ispartofExperimental Eye Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectHumanen_US
dc.subjectTear Analysisen_US
dc.subjectAtopic Keratoconjunctivitisen_US
dc.subjectFlow Cytometryen_US
dc.subjectHelper T Lymphocyteen_US
dc.subjectSuppressor T Lymphocyteen_US
dc.subjectMemory T Helper Lymphocyteen_US
dc.titleFurther Studies on the Immunopathology of Atopic Keratoconjunctivitis Using Flow Cytometryen_US
dc.typeArticleen_US

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