Comparison of 4- and 8-h dialysis sessions in thrice-weekly in-centre haemodialysis

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dc.contributor.authorOk, Ercan
dc.contributor.authorDuman, Soner
dc.contributor.authorAsci, Gulay
dc.contributor.authorTumuklu, Murat
dc.contributor.authorSertoz, Ozen Onen
dc.contributor.authorKayikcioglu, Meral
dc.contributor.authorToz, Huseyin
dc.date.accessioned2020-03-26T18:13:58Z
dc.date.available2020-03-26T18:13:58Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground. Longer dialysis sessions may improve outcome in haemodialysis (HD) patients. We compared the clinical and laboratory outcomes of 8- and 4-h thrice-weekly HD. Methods. Two-hundred and forty-seven HD patients who agreed to participate in a thrice-weekly 8-h in-centre nocturnal HD (NHD) treatment and 247 age-, sex-, diabetes status-and HD duration-matched control cases to 4-h conventional HD (CHD) were enrolled in this prospective controlled study. Echocardiography and psychometric measurements were performed at baseline and at the 12th month. The primary outcome was 1-year overall mortality. Results. Overall mortality rates were 1.77 (NHD) and 6.23 (CHD) per 100 patient-years (P = 0.01) during a mean 11.3 +/- 4.7 months of follow-up. NHD treatment was associated with a 72% risk reduction for overall mortality compared to the CHD treatment (hazard ratio = 0.28, 95% confidence interval 0.09-0.85, P = 0.02). Hospitalization rate was lower in the NHD arm. Post-HD body weight and serum albumin levels increased in the NHD group. Use of antihypertensive medications and erythropoietin declined in the NHD group. In the NHD group, left atrium and left ventricular end-diastolic diameters decreased and left ventricular mass index regressed. Both use of phosphate binders and serum phosphate level decreased in the NHD group. Cognitive functions improved in the NHD group, and quality of life scores deteriorated in the CHD group. Conclusions. Eight-hour thrice-weekly in-centre NHD provides morbidity and possibly mortality benefits compared to conventional 4-h HD.en_US
dc.description.sponsorshipEuropean Nephrology and Dialysis Institution (E.N.D.I, Germany)en_US
dc.description.sponsorshipThe study was supported by the European Nephrology and Dialysis Institution (E.N.D.I, Germany) with an unrestricted grant. The sponsor had no role in study design and conduction, data management, collection and analysis, preparation and submission of the manuscript. The following investigators participated in the 'Long Dialysis Study': Ali Basci, Fatih Kircelli, Ebru Sevinc, Ender Hur, Pinar Ergin, Ismet Onder Isik, Murat Zengin, Alfert Sagdic, Erkan Kayali, Can Boydak, Taskin Colak, Sihli Cahskan, Hakan Kaplan, Hasibe Ulas, Sait Kirbiyik and Hakan Berktas. We thank Dr Christopher R. Blagg, Dr Zbylut J. Twardowski and Dr Evert J. Dorhout Mees for their expert advice in writing and revising the manuscript.en_US
dc.identifier.doi10.1093/ndt/gfq724en_US
dc.identifier.endpage1296en_US
dc.identifier.issn0931-0509en_US
dc.identifier.issue4en_US
dc.identifier.pmid21148270en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1287en_US
dc.identifier.urihttps://dx.doi.org/10.1093/ndt/gfq724
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26247
dc.identifier.volume26en_US
dc.identifier.wosWOS:000289309400027en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOXFORD UNIV PRESSen_US
dc.relation.ispartofNEPHROLOGY DIALYSIS TRANSPLANTATIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectin-centre haemodialysisen_US
dc.subjectnocturnalen_US
dc.subjectoutcomesen_US
dc.subjectsurvivalen_US
dc.titleComparison of 4- and 8-h dialysis sessions in thrice-weekly in-centre haemodialysisen_US
dc.typeArticleen_US

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